ABSTRACT
Objective To evaluate the effect of Jinqiao-Reduqing granule in the treatment of children with herpes angina fever.Methods A total of 90 children with herpes angina were randomly divided into two groups,with 45 cases in each group.Both groups received the symptom-supported treatment.On this basis,the control group took ribavirin granules,while the observation group took Jinqiao-Reduqing granule.Both groups were treated for 4 days.The symptoms and signs were scored before and after treatment.The fever abatement time,herpes subsidence time,salivation disappearance time and appetite recovery time were observed and recorded.The serum levels of IL-2,IL-6,IL-10 and TNF-α were detected by ELISA,and peripheral blood levels of CD4+,CD8+,CD4+/CD8+ were detected by flow cytometry.Results After treatment,the scores of symptoms and signs in the observation group were significantly lower than those in the control group (3.02 ± 2.89 vs.6.88 ± 2.31;t=6.999,P＜0.01).The time of fever abatement (16.8 ± 3.2 h vs.29.9 ± 4.4 h,t=16.202),herpes subsidence (72.3 ± 5.4 h vs.96.7 ± 6.2 h,t=19.765),salivation disappearance (26.4 ± 2.0 h vs.46.3 ± 3.6 h,t=32.479) and appetite recovery (19.6 ± 4.2 h vs.39.7 ± 4.9 h,t=20.907) were significantly earlier than those in the control group (P＜0.01).After treatment,the serum levels of IL-2,IL-6,IL-10 and TNF-α in the observation group were lower than those in the control group (t were 4.974,4.410,6.447 and 4.767,respectively,all Ps＜0.01);CD4+ levels and CD4+/CD8+ were significantly higher than those in the control group (t were 4.033,6.860,all Ps＜ 0.01),and CD8+ levels was significantly lower than those in the control group (t=4.928,P＜0.01).Conclusions The Jinqiao-Reduqing granule can shorten the time of symptoms subsidence,reduce the level of inflammatory cytokines and improve the immunity of children with herpes angina fever.
ABSTRACT
Wumei Pills is a prescription for the treatment of ascariasis of biliary tract and chronic diarrhea. It can be widely used in the treatment of many diseases with the basic pathogenesis "simultaneous occurrence of cold and heat" because of its features of cold-heat combination and tonifying-purgation combination. What should be noticed is that it is necessary to use large dose of Mume Fructus, which is also can be applied to the treatment of chronic diseases. Carefully sticking to pathogenesis in clinical treatment can obtain good efficacy.
ABSTRACT
PURPOSE: The simultaneous occurrence of two distinct neoplasms derived from different cells of origin is a recognized entity. It presents uncommonly in all organs,and very rarely in the thyroid gland. METHODS: Six patients with concurrent medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) were seen between January 2000 and June 2007. Clinicopathological features were evaluated, and follow-up for the patients was obtained. RESULTS: All patients were female, with ages ranging from 39 to 63 years (mean age, 55.4 years). Five of six patients were incidentally detected during a medical check-up. The medullary carcinomas measured from 0.5 to 4.0 cm in diameter (mean diameter, 1.72 cm), while the papillary carcinomas ranged from 0.2 to 1.4 cm in diameter (mean diameter, 0.72 cm). Treatment consisted of a total thyroidectomy (n=5) and hemithyroidectomy (n=1) with central compartment node dissection. In twopatients, prophylactic bilateral neck dissection was also added. Supplemental radioactive iodine treatment was administered in five patients. During a mean follow-up period of 41.8 months, two patients showed recurrence in the lateral neck nodes, one recurrence from a papillary carcinoma and the other recurrence from a medullary carcinoma. After re-operation for the recurrent lesions, allof the patients were alive andfree of disease. CONCLUSION: Attention should be given to the possibility of the simultaneous occurrence of MTC and PTC. Treatment for concurrent MTC and PTC should be based on the treatment for MTC, considering the more aggressive behavior of the tumor than PTC.
ABSTRACT
Diarrhea-associated hemolytic uremic syndrome is rarely accompanied by complications requiring surgical intervention. We report a case of the diarrhea-associated hemolytic uremic sydrome which developed simultaneously with an acute appendicitis.