ABSTRACT
INTRODUCCIÓN: La vacunación es la única herramienta práctica para detener la expansión y erradicar la pandemia COVID-19, la mayoría de las vacunas han demostrado capacidad de inducir respuestas inmunitarias. Es predecible que existan varias vacunas con distintos niveles de protección por lo que su uso dependerá en cada país de las autoridades sanitarias y recomendaciones de la Organización Mundial de la Salud (OMS). OBJETIVO: Determinar los Eventos Adversos (ESAVIS) de la vacuna Sinopharm administrada en personas adultas en el punto de vacunación masivo de la Red de salud N°4 ESTE de la ciudad de La Paz, meses de abril a octubre gestión 2021. MATERIAL Y MÉTODOS: Se realizó un estudio descriptivo, observacional, muestra de 60 casos, con diagnóstico de Eventos Supuestamente atribuibles a la vacunación y/o inmunización. Los métodos empleados fueron análisis documental, instrumentos usados fichas ESAVIS del Ministerio de Salud y Deportes. Se recogieron datos sociodemográficos, sexo y edad. RESULTADOS: Las personas que presentaron eventos adversos a la Vacuna Sinopharm son del sexo femenino en un 78,3% con un promedio de edad 44 años, con antecedentes patológicos de Hipertensión Arterial Sistèmica en un 5%, el medicamento administrado en un 83,3% es el oxígeno, el síntoma más frecuente son los mareos 58,3%, se presentó más ESAVIS leves en un 98,3%. CONCLUSIÓN: Las personas que recibieron la vacuna Sinopharm presentan ESAVIS Leves.
INTRODUCTION: Vaccination is the only practical tool to stop the expansion and eradicate the COVID-19 pandemic, most vaccines have demonstrated the ability to induce immune responses. It is predictable that there are several vaccines with different levels of protection, so their use will depend in each country on the health authorities and recommendations of the World Health Organization (WHO). OBJECTIVE: To determine the Adverse Events (ESAVIS) of the Sinopharm vaccine administered to adults at the mass vaccination point of the Health Network No. 4 ESTE of the city of La Paz, from April to October, 2021. MATERIAL AND METHODS: A descriptive, observational study was carried out, a sample of60 cases, with a diagnosis of Events Supposedly attributable to vaccination and/or immunization. The methods used were documentary analysis, instruments used ESAVIS files from the Ministry of Health and Sports. Sociodemographic data, sex and age were collected. RESULTS: The people who presented adverse events to the Sinopharm Vaccine are 78.3% female with an average age of 44 years, with a pathological history of Systemic Arterial Hypertension in 5%, the medication administered in 83.3% is oxygen, the most frequent symptom is dizziness 58.3%, more mild ESAVIS occurred in 98.3%. CONCLUSION: People who received the Sinopharm vaccine have Mild ESAVIS.
ABSTRACT
Protection against severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection of inactivated vaccines is not well characterized in people with comorbidities, who are at high risk of severe infection. We compared the risk of SARS-CoV-2 infection after complete vaccination with Sinopharm/BBIBP in people with comorbidities (e.g., autoimmune diseases, cardiovascular disease, chronic lung disease, and diabetes) with healthy individuals using a Cox-proportional hazard model. In July-September 2021, a total of 10 548 people (comorbidities, 2143; healthy, 8405) receiving the complete primary series of vaccination with Sinopharm/BBIBP in Bangkok, Thailand were prospectively followed for SARS-CoV-2 infection through text messaging and telephone interviewing for 6 months. A total of 295 infections from 284 participants were found. HRs (95% CI) of individuals with any comorbidities did not increase (unadjusted, 1.02 (0.77-1.36), P = 0.89; adjusted, 1.04 (0.78-1.38), P = 0.81). HRs significantly increased in the subgroup of autoimmune diseases (unadjusted, 2.64 (1.09-6.38), P = 0.032; adjusted, 4.45 (1.83-10.83), P = 0.001) but not in cardiovascular disease, chronic lung disease, or diabetes. The protection against SARS-CoV-2 infection of the Sinopharm vaccine was similar in participants with any comorbidities vs. healthy individuals. However, the protection appeared lower in the subgroup of autoimmune diseases, which may reflect suboptimal immune responses among these people.
Subject(s)
Humans , COVID-19/prevention & control , Vaccines, Inactivated , COVID-19 Vaccines , SARS-CoV-2 , Cardiovascular Diseases , Prospective Studies , Thailand , Autoimmune Diseases , Diabetes Mellitus/epidemiologyABSTRACT
Introducción: Después de la COVID-19, surgieron luego de muchas investigaciones un suministro de vacunas aprobadas a nivel mundial, dichas vacunas deben conferir una protección eficaz por un tiempo prolongado, poseer un buen perfil de seguridad, ser asequible y ser fácilmente accesible para todos, un reto difícil de conseguir por el tiempo y las características del virus. Objetivo: determinar la concentración de anticuerpos neutralizantes (A. N.) post vacunación en una población de trabajadores del Banco de Sangre Material y métodos: Se realizó un estudio prospectivo, descriptivo, transversal, tomando como población de estudio a todo el personal del Banco de Sangre, varones y mujeres con un rango de edad entre 26 y 72 años, se evaluó el aumento de A. N. después de inoculada la segunda dosis de Sinopharm en fecha 19/05/21, luego se midió la cantidad de anticuerpos generados en fecha 20/10/21 previo a la tercera dosis de refuerzo de Astrazeneca, evaluando nuevamente a los 35 días luego de la tercera dosis 02/12/2021 para finalmente evaluar estos niveles en fecha 26/01/2022. La técnica utilizada fue (ELISA) de la marca EUROIMMUN Anti-SARS- CoV-2 S1 del tipo IgG. Resultados y conclusiones: Se puede verificar que la concentración de A. N. producidos por la vacunación desde Sinopharm y el refuerzo con Astrazeneca favoreció a que dichos anticuerpos se mantengan altos en el tiempo (322 días luego de la primera dosis) llegando a un 80% de la concentración máxima en la lectura final. Concluimos que con cada refuerzo de vacuna anti SARS-CoV-2 el título de A.N. sube de manera significativa, motivo por el cual consideramos importante en nuestro pais una cuarta dosis como método preventivo y de inmunidad.
Introduction: After COVID-19, emerged after much research a supply of vaccines approved worldwide, these vaccines must confer effective protection for a prolonged time, possess a good safety profile, be affordable and be easily accessible to all, a challenge difficult to achieve due to the time and characteristics of the virus. Objective: to determine the concentration of neutralizing antibodies post vaccination in a population of Blood Bank workers; Material and methods: A prospective, descriptive, observational, cross-sectional study was carried out, taking as study population all the Blood Bank personnel, among men and women with an age range between 26 and 72 years old. the increase of Neutralizing Antibodies was evaluated after inoculation of the second dose of Sinopharm on 05/19/21, then the amount of antibodies generated was measured on 10/20/21 prior to the third booster dose of Astrazeneca, evaluating again 35 days after the third dose on 12/02/2021 and finally evaluating these levels on 01/26/2022. The technique used was the EUROIMMUN Anti-SARS-CoV-2 S1 ELISA. Results and conclusions: It can be verified that the concentration of N.A. produced by vaccination from Sinopharm and the booster with Astrazeneca favored that these antibodies remained high over time (322 days after the first dose) reaching 80% of the maximum concentration in the final reading. We conclude that with each booster of anti SARS CoV 2 vaccine, the titer of N.A. rises significantly, which is why we consider important in our country a fourth dose as a preventive and immunity method.