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Objective This study aimed to investigate the MRI features of forearm muscles from myotonic dystrophy type 1(DM1)and to evaluate the correlation between clinical factors and muscle MRI.Methods We retrospectively reviewed the medical records of genetic-confirmed DM1 patients including the clinical manifestations,the electromyography and the muscle pathology results.MRI scan was used to examine forearm muscles.Analysis of T1weighed images and short inversion time inversion recovery images were used to evaluate muscle fatty infiltration and muscle edema,respectively.The correlation between the fatty infiltration and age,disease duration and muscle strength were investigated.Results Twenty-three DM1 patients from different family were enrolled.The onset age was 17～60 year-old,mean age was(34.3±12.2)year-old,and the mean course of disease was 5(3,9)years.Their main symptoms were hand weakness and stiffness,accompanying with alopecia and excessive daytime sleepiness.The median fatty infiltration scores were recorded as follows:flexor digitorum profundus(FDP)4.0(3.0,4.0),flexor pollicis longus(FPL)4.0(3.0,4.0),extensor pollicis brevis 2.0(1.0,2.5),abductor pollicis longus 2.0(0.5,2.5),extensor pollicis longus 2.0(1.0,2.0),flexor digitorum superficialis 2.0(0.5,2.5),supinator(S)2.0(1.0,2.0).Other muscles scores were less than 1 of which the pronator teres(PT)was 1.0(0.0,1.0).Atrophy of FDP was detected in nine,atrophy of FPL in six and hypertrophy of PT in 11 patients.The muscle edema was evident in FDP,FPL,and the flexor digitorum superficialis,while brachioradialis and pronator teres were normal.There was no significant correlation between mean muscle fat infiltration score and age or course of disease.The mean muscle fat infiltration was significantly correlated with muscle strength score(r =-0.590,P<0.01).The mean fatty infiltration scores of FDP and FPL were not correlated with age nor course of disease,but correlated with grip strength(r =-0.754,P<0.01 and r =-0.699,P<0.01).Conclusion The forearm MRI in DM1 patients exhibit a relatively specific distribution of selective muscle involvement and can be used to assess muscle weakness.
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Abstract Phlomidoschema parviflorum (Benth.) Vved. (Basionym: Stachys parviflora Benth.) Lamiaceae, have significance medicinal importance as it is used in number of health disorders including diarrhea, fever, sore mouth and throat, internal bleeding, weaknesses of the liver and heart genital tumors, sclerosis of the spleen, inflammatory tumors and cancerous ulcers. The present contribution deals with the sedative and muscle relaxant like effects of diterpenoids trivially named stachysrosane and stachysrosane, isolated from the ethyl acetate soluble fraction of P. parviflorum. Both compounds (at 5, 10 and 15 mg/kg, i.p) were assessed for their in vivo sedative and muscle relaxant activity in open field and inclined plane test, respectively. The geometries of both compounds were optimized with density functional theory. The molecular docking of both compounds were performed with receptor gamma aminobutyric acid. Both compounds showed marked activity in a dose dependent manner. The docking studies showed that both compounds interact strongly with important residues in receptor gamma aminobutyric acid. The reported data demonstrate that both compounds exhibited significant sedative and muscle relaxant-like effects in animal models, which opens a door for novel therapeutic applications.
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Objective To observe the effect of 8-week climbing ladder exercise with load on the expression of proliferator-activated receptor gamma coactivator 1-alpha (PGC1α)/ fibronectin type Ⅲ domain containing 5 (FNDC5)/ myostatin (MSTN)in soleus and extensor digitorum longus muscle and the serum concentration of irisin in Sprague-Dawley (SD)rats.Methods Twenty SD rats were randomly divided into a control (Con,n=10)group and a climbing ladder (Lad,n=10)group.The Lad group took an 8-week and once-every-3-day program of resistance exercise using an improved model of climbing ladder with load.Then the soleus and extensor digitorum longus muscles were isolated at 48 h after exercise.The PGC1α/FNDC5/MSTN mRNA and protein expression in the skeleton muscle were detected using quantitative PCR and Western blotting respectively.The serum concentration of irisin was measured using enzyme-linked immunosorbent assay.Results Compared with Con group,the expression of PGC1α in the soleus muscle reduced significantly (P＜0.05),that of FNDC5 reduced but without significance and that of MSTN increased significantly (P＜0.05)in Lad group.However,the expression of PGC1α in the extensor digitorum longus muscle increased significantly (P＜0.05),that of FNDC5 increased but without significance and that of MSTN decreased significantly (P＜0.05)in Lad group compared with Con group.There were no significant differences in the serum concentration of irisin between the two groups.Conclusion Eight-week climbing ladder exercise with load on rats induces differential expression of PGC1α/FNDC5/MSTN in soleus and extensor digitorum longus muscle,but doesn't influence the serum concentration of irisin.It is suggested that there may be a complex mechanism of balancing and antagonism in the body after long-term resistance exercises.
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Introducción: Las lesiones músculoesqueléticas son un problema sumamente frecuente en México, sin embargo no existen estadísticas sobre su epidemiología; existen datos de acuerdo con el Sistema Nacional de Salud de la prevalencia de fracturas que fueron causantes de alrededor 85 964 hospitalizaciones en hombres y en mujeres de 52 042, mientras que en luxaciones y esguinces, su prevalencia en hombres fue de 7 486 y en mujeres de 3 878 que representaron cerca del 2% del total; estas lesiones son: contusiones, fracturas, esguinces, luxaciones y lesión muscular (domat), su incidencia supone entre el 10% y 55% de todas estas lesiones3. Objetivo: Identificar la incidencia y describir los factores predisponentes de lesiones músculoesqueléticas en mujeres adultas sedentarias con factores de riesgo de osteoporosis y que inician un programa de ejercicio físico para mejorar la densidad mineral ósea. Metodología: Estudio prospectivo, longitudinal y descriptivo, conformado por N = 99 mujeres sedentarias entre 45 a 60 años de edad con factores de riesgo para padecer osteoporosis, que ingresaron al proyecto "Eficacia de un programa de entrenamiento físico para mejorar la densidad mineral ósea". Para el tratamiento estadístico se obtuvieron medidas de tendencia central, dispersión y de correlación. Resultados: 26% de las mujeres presentaron lesiones inducidas por el ejercicio físico, como bursitis rotuliana, esguince grado 1 y 2, fisura de tibia, periostitis y dolor muscular de aparición tardía o Domat. A pesar de que las características físicas predominantes en estas mujeres no fueron favorables comparándolas con los parámetros esperados para su edad, sexo y actividad física, no podemos afirmar que estas hayan sido los factores predisponentes para sufrir lesiones, ya que su correlación no resultó estadísticamente significativa. Discusión: No encontramos reportada la frecuencia de lesiones en este tipo de población que inicie un programa de ejercicio físico, por lo tanto no tenemos referentes para comparar la incidencia. Conclusiones: A pesar de que el ejercicio físico fue organizado y controlado y se otorgó cuidado integral con énfasis en la prevención, se presentaron lesiones músculo esqueléticas.
Introduction: musculoskeletal injuries are extremely common problem in Mexico, but there are no statistics on the epidemiology data are in agreement with the National Health System of the prevalence of fractures that were the cause of about 85 964 hospitalizations men and women of 52 042, while dislocations and sprains, its prevalence in males was 7 486 and 3 878 women representing about 2% of the total. These injuries are bruises, fractures, sprains, dislocations and muscle injury (domat), its incidence is between 10% and 55% of all these lesiones3. To identify the incidence and describe the predisposing factors of musculoskeletal injuries in sedentary adult women with risk factors for osteoporosis and initiate an exercise program to improve bone mineral density. Methods: Prospective, longitudinal, descriptive, consisting of N = 99 sedentary women 45 to 60 years old with risk factors for osteoporosis, which joined the project "Effectiveness of a physical training program to improve bone mineral density". For statistical treatment were measured central tendency, dispersion and correlation. Results: 26% of women had lesions induced by exercise, such as patellar bursitis, sprain, grade 1 and 2, crack of tibia, periostitis and delayed onset muscle soreness or Domat. Although the physical characteristics prevalent in these women were not favorable compared with the expected parameters for age, sex and physical activity can not say that these have been the predisposing factors for injury, because their correlation was not statistically significant . Discussion: We found the frequency of injuries reported in this population to engage in an exercise program, therefore we have no benchmark to compare the incidence. Conclusions: Although exercise was organized and controlled and was given comprehensive care with emphasis on prevention, musculoskeletal lesions.
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Humans , Female , Middle Aged , Sedentary Behavior , ExerciseABSTRACT
Objective To probe into the efficacy and nursing intervention method for simple rib fracture treated by Skeleton Muscle Disease Healing Membrane(SMDHM)combined with TDP irradiation. Methods 120 patients with rib fracture were randomly divided into treatment group and control group. For the treatment group,the patients stuck SMDHM to the place of rib fracture,and then were treated by TDP irradiation. The control group was treated by the conventional method of fixation by rib bandage. Results The fracture healing time of treatment group was short, and antaigic effect was prominent. While, the healing time of control group was long and antaigie effect was poor. For the efficacy observation of the two groups,the statistical difference was extremely significant(P< 0.05). Conclusion The efficacy of SMDHM combined with TDP irradiation for fib fracture is distinctly superior to conventional method. This new treatment is simple,practical and economical, and is easily accepted by patients. Therefore it's worth extensively popularizing in the clinic application.