ABSTRACT
OBJECTIVE:To observe the clinical efficacy and safety of pregabalin assisting anti-histamine drugs in the treat-ment of secondary skin pruritus in uremic patients underwent maintenance hemodialysis. METHODS:140 uremic patients with sec-ondary skin pruritus underwent maintenance hemodialysis were randomly divided into control group and treatment group,with 70 cases in each group. Control group was given loratadine orally,10 mg,qd. Treatment group was additionally given pregabalin on the basis of control group,75 mg,po,at night of hemodialysis end,increasing by 75 mg every week if no obvious relief was found,maximal dose of 300 mg. Both group received 3 months of treatment. Clinical efficacy,VAG itching score,modified Duo score,PSQI score before and after treatment and the incidence of ADR were compared between 2 groups. RESULTS:Total effec-tive rate of treatment group (90.00%) was significantly higher than that of control group (71.43%),with statistical significance (P0.05). CONCLUSIONS:Pregabalin assisting anti-histamine drugs in the treatment of secondary skin pruritus in uremic patients with maintenance hemodialysis can efficiently relieve the itching symptoms,improve sleep quality,and not increase the risk of ADR.
ABSTRACT
Objective To explore the role of sanyrene in decreasing skin itching and observe its therapeutic effect on skin pruritus in patients with diabetes. Methods According to the principle of voluntary patients, 221 cases were divided into three groups: conventional therapy plus calamine smear including 80 cases, conventional therapy plus sanyrene including 80 cases and the conventional treatment only control group including 61 cases. Results Generalized estimating equations were established. Referring to the control group, model one was established. The coefficients in sanyrene treatment and calamine control group were 2.20 and 1.29 respectively (P<0.01). The therapeutic efficacy was significantly increased with 9.03 (OR=e2.20) times in sanyrene group and 3.63 (OR=e1.29) times in calamine group compared to the blank control,indicating effect of sanyrene and calamine were better than the control group;Referring to calamine group, Model two was established,shows better efficacy of sanyrene in calamine. The coefficients in sanyrene treatment and blank control group were 0.91 and-1.29 respectively (P<0.01). The therapeutic efficacy was significantly increased 2.48 (OR = e0.91) times in sanyrene group and 0.28 (OR = e-1.29) times in blank group compared to calamine control. Conclusions Sanyrene is effective in improving in diabetic skin pruritus situation. And compared with calamine, the treatment efficacy of sanyrene is better, which suggesting that sanyrene can be used in the clinical treatment of diabetic skin pruritus.