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Objective To explore the clinical effect of Smecta combined with Kangfuxin Liquid in the treatment of stomatitis and oral ulcer.Methods From January 2015 to April 2017,102 patients with stomatitis and oral ulcers in Heji Hospital Affiliated to Changzhi Medical College were selected and randomly divided into observation group and control group according to the digital table.The patients in the control group were treated with stomatitis/oral ulcer sprays.The patients in the observation group were treated with Smecta combined with Kangfuxin Liquid.The therapeutic effect of the two groups was evaluated and analyzed.Results The overall therapeutic effect of the observation group(92.16％)was significantly better than that of the control group(72.55％),the difference was statistically significant(χ2=9.259,P<0.05).The mean ulcer and pain scores of the observation group were significantly lower than those of the control group(t1=-4.362,t2=-5.174,all P<0.05).Conclusion The combination of Kangfuxin Liquid and Smecta in the treatment of stomatitis and oral ulcers can effectively promote ulcer surface repair,help to reduce the local swelling and pain,and has positive role in improving patients'compliance and quality of life,it is recommended in clinical.
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Objective To investigate the clinical effect of rhubarb combined with smecta in the treatment of acute organophosphorus pesticide poisoning (AOPP).Methods Seventy-six patients with severe AOPP admitted in the Emergency Centre of Heze Municiple Hospital in Shandong Province from June 2011 to June 2014 were enrolled in this study. They were divided into observation group and control group by the random number table method, 38 cases in each group. The comprehensive routine treatment of gastric lavage to thoroughly clear the gastric content, appropriate application of penehyclidine and atropine for detoxication, pralidoxime chloride, etc. were given to the two groups. On the basis of the above conventional treatment, the observation group was treated with rhubarb 30 g for catharsis and smecta 30 g for adsorption once in every 4 hours, two drugs applied alternately for 48 hours, while the control group was treated with 33% magnesium sulfate 60 mL for catharsis and bleaching clay 200 g for adsorption once in every 4 hours, two drugs applied alternately for 48 hours. The treatment effect, dosage, incidence of complication and case fatality rate in both groups were observed.Results The first defecation time (hours: 5.8±3.7 vs. 9.4±4.6), gastrointestinal function recovery time (hours: 21.7±6.1 vs. 25.2±8.3), atropinization time (minutes: 51.8±23.9 vs. 68.5±20.1), conscious recovery time (days: 2.3±1.2 vs. 3.6±1.9), the time of cholinesterase (ChE) activity returning to more than 50% (days: 4.7±2.3 vs. 6.1±2.9) and the length of stay in hospital (days: 9.2±4.9 vs. 12.3±6.9) were obviously shorter in the observation group than those of the control group (P < 0.05 orP < 0.01); the used dosage of atropine (mg: 234.3±37.1 vs. 265.7±31.4) and penehyclidine (mg: 19.2±14.3 vs. 36.7±25.4) and the incidence of adverse reactions of poisoning rebound [7.9% (3/38) vs. 31.6% (12/38)], intermediate syndrome [2.6% (1/38) vs. 18.4% (7/38)], delayed neuropathy [0 (0/38) vs. 15.8% (6/38)] in the observation group were significantly lower than those of the control group (P < 0.05 orP < 0.01). No death occurred in both groups.Conclusion At present, the combination of smecta and rhubarb is a relatively good method of catharsis and adsorption to completely clear the gastrointestinal toxic residues inside the patients with AOPP, and it can reduce the amount of drugs used, the incidence of complications and the duration of hospital stay.
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Objective To investigate the effect of Smecta on II pressure ulcers in elderly patients.Methods Fifty-two elderly patients with skin pressure ulcers hospitalized in our hospital during February 2011 and September 2012 were randomly divided into experimental group(n=26),in which Smecta was applied on the pressure ulcers,and control group(n=26),in which ulcers powders were applied on the ulcers.The two groups were compared concerning the curative effects.Results The curative effect in the experimental group was significantly better than that of the control group(P<0.05)and the time for ulcers healing in the former group was significantly shorter than that of the control(P<0.05).Conclusions Smecta is more effective in the treatment of pressure ulcers in elderly patients with II pressure ulcers.It is simple in clinical use and cheap in cost,which should be encouraged for wider use.
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@#BACKGROUND: The plasma concentration of paraquat is closely related to the prognosis of patients with paraquat toxication, and the most common cause of death from paraquat poisoning is multiple organ failure (MOF). This study aimed to evaluate therapeutic effect of smecta on the plasma concentrations of paraquat and multi-organ injury induced by paraquat intoxication in rats. METHODS: A total of 76 healthy adult SD rats were randomly divided into group A (control group, n=6), group B (poisoned group, n=30) and group C (smecta-treated group, n=30). Rats in groups B and C were treated intragastrically with PQ at 50 mg/kg, and rats in group A was treated intragastrically with saline (1 mL). Rats in group C were given intragastrically smecta at 400 mg/kg 10 minutes after administration of PQ, while rats in other two groups were treated intragastrically with 1 mL saline at the same time. Live rats in groups B and C were sacrificed at 2, 6, 24, 48, 72 hours after administration of PQ for the determination of paraquat plasma concentrations and for HE staining of the lung, stomach and jejunum. The rats were executed at the end of trial by the same way in group A. RESULTS: The plasma concentration of paraquat (ng/mL) ranged from 440.314±49.776 to 4320.6150±413.947. Distinctive pathological changes were seen in the lung, stomach and jejunum in group B. Lung injuries deteriorated gradually, edema, leukocyte infiltration, pneumorrhagia, incrassated septa and lung consolidation were observed. Abruption of mucosa, hyperemic gastric mucosa and leukocyte infiltration were obvious in the stomach. The hemorrhage of jejunum mucosa, the abruption of villus, the gland damage with the addition of inflammatory cell infiltration were found. Compared to group B, the plasma concentration of paraquat reduced (P<0.01) and the pathological changes mentioned above were obviously alleviated in group C (P<0.05, P<0.01). CONCLUSION: Smecta reduced the plasma concentration of paraquat and alleviated pathologic injury of rats with PQ poisoning.
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ObjectiveTo evaluate therapeutic effect and the possible mechanism of smecta on paraqual plasma concentrations and multiorgans injury induced by paraquat intoxication in rats. Methods A total of 76 healthy adult SD rats were randomly ( random number) divided into group A (control group n =6),group B ( poisoned group n =30 ),group C (smecta-treated group n=30).Rats in groups B and C were treated intragastrically with PQ at 50 mg/kg,the rats in the group C were given with smecta at 50 mg/kg,while the rats in the other two groups were only intragastrically adminstered with saline.Live rats in groups B and C were sacrificed at 2,6,24,48,72 h after administration of PQ for the determination of paraquat plasma concentrations and for HE staining of lung,stomach and jejunum.The rats were executed at the end of trial by the same way in group A.All measurement data were expressed as means + standard deviation ((x) ±s).The data of pathological score were compared with Independent-samples T test and the data of PQ concentration compared with analysis of variance (ANOVA) followed by LSD-t multiple comparison test.P-values of less than 0.05 were considered statistically significant.ResultsThe paraquat plasma concentration ( ng/ml ) was 440.314 ± 49.776 to 4320.6150 ± 413.947.There were different pathological changes of lung,stomach and jejunum in group B. Lung injuries gradually deteriorated,congestion,edema,leukocyte infiltration,incrassated septa and lung consolidation were observed.The pathological changes were obvious such as abruption of mucosa,hyperemic gastric mucosa and leukocyte infiltration in stomach.Haemorrhage of jejunum mucosa,abruption of villus,gland damage and inflammatory cell infiltration were found. Compared with group B,all the pathological changes mentioned above were obviously alleviated in group C ( P ＜ 0.05 ),and the concentrations reduced ( P ＜ 0.01 ).Conclusions Smecta reduced paraquat plasma concentrations and alleviated pathologic injury of rats with PQ poisoning.
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Objective To observe clinical effect of treating infantile chronic diarrhea with Shenlingbaizhu powder and smecta.Methods 82 cases with chronic diarrhea were randomly divided into a control group and a treatment group.The control group was taken smecta orally,and the treatment group was taken Shenlingbaizhu powder together with smecta orally.10 days constitute a treatment course.Atier two courses,the therapeutic effects were observed in the treatment group and the control group respectively.Results The total effective rate was 92.9%and 77.5%in the treatment group the control group respectively,showing a significant difference(P＜0.05).Conclusion The treatment of infantile chronic diarrhea with Shenlingbaizhu powder and smecta has a better effect.
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Objective To study the clinical effects of tearing pediatric diarrhea with traditional Chinese and western medicine.Methods Altogether 520 patients with pediatric diarrhoea were recruited into three groups:the group treated with combined traditional Chinese and western medicine,the group treated with Chinese medicine and the group treated with western medicine.Observe clinical effects of each group.Results In 175 cases of the group treated with combined traditional Chinese and western medicine,66 cases show significant effects,64 cases are effective,45 eases are ineffective,and the effective rate is 74.30%;In 171 cases of the group of treated with traditional Chinese medicine,32 eases show significant effects,42 eases are effective,97 cases are ineffective,and the effective rate is 43.30%;In 174 eases of the group of treated with western medicine,35 eases show significant effects,43 eases are effective,96 eases are ineffective,and the effective rate is 44.80%.The effective rate of the group treated with combined Chinese medicine and western medicine was significantly better than the other two groups (P＜0.01).Conclusion Combined Chinese and western medicine is more effective in treating the patients with pediatric diarrhea,and it is worthy of spread.
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Objective: To explore the therapeutic effect of Golden bifid combined with smecta for the patients with hepatogenous diarrhea (HD). Methods: 66 patients with HD were randomly divided into treatment group (n=33) and control group (n=33).On the basis of protecting the liver and the complex treatment, the treatment group was given Golden bifid (2.0g,three times a day) combined with smecta (3.0g,three times a day), and the control group was given levofloxacin (0.2g, twice a stools. the total efficiency (remarkable effect and effective) of two groups was calculated. Results: The total effective rate of treatment group was 90.9%, while that of the control group was 48.5%. There were statistically significant differences between the two groups (x2=14.19,P＜0.01). Conclusion: The clinical therapeutic effect of Golden bifid combined with smecta for the patients with hepatogenous diarrhea is remarkable,which is worth spreading in the clinical application.
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Objective: To explore the therapeutic effect of Golden bifid combined with smecta for the patients with hepatogenous diarrhea (HD). Methods: 66 patients with HD were randomly divided into treatment group (n=33) and control group (n=33).On the basis of protecting the liver and the complex treatment, the treatment group was given Golden bifid (2.0g,three times a day) combined with smecta (3.0g,three times a day), and the control group was given levofloxacin (0.2g, twice a stools. the total efficiency (remarkable effect and effective) of two groups was calculated. Results: The total effective rate of treatment group was 90.9%, while that of the control group was 48.5%. There were statistically significant differences between the two groups (x2=14.19,P＜0.01). Conclusion: The clinical therapeutic effect of Golden bifid combined with smecta for the patients with hepatogenous diarrhea is remarkable,which is worth spreading in the clinical application.
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Objective: To explore the therapeutic effect of Golden bifid combined with smecta for the patients with hepatogenous diarrhea (HD). Methods: 66 patients with HD were randomly divided into treatment group (n=33) and control group (n=33).On the basis of protecting the liver and the complex treatment, the treatment group was given Golden bifid (2.0g,three times a day) combined with smecta (3.0g,three times a day), and the control group was given levofloxacin (0.2g, twice a stools. the total efficiency (remarkable effect and effective) of two groups was calculated. Results: The total effective rate of treatment group was 90.9%, while that of the control group was 48.5%. There were statistically significant differences between the two groups (x2=14.19,P＜0.01). Conclusion: The clinical therapeutic effect of Golden bifid combined with smecta for the patients with hepatogenous diarrhea is remarkable,which is worth spreading in the clinical application.
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0.05),but the t1/2 was longer and the AUC and the Cmax were lower in group B than in other groups(P
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Objective To observe the therapeutic efficacy of combination of smecta and P.O.Bifidobigen in treatment of infantile diarrhea .Methods 100 cases with infantile diarrhea were collected randomly. 6 2cases were treated with combination of smecta and P.O.Bifi dobige n,while 62 cases were treated with s mecta alone .Results 62 cases(62%)showed an obvious efficacy ;30 cases(30%)did effective;8cases(8%)showed no effective .The total effective rate was 92.4%.For infectious and symptomatic diarrhea,there was not difference of effective rates between the two therapies.For digestive dysfunction and chronic diarrhea accomplished with malnutrition,just the combination of the two drugs showed efficacy .Conclusions For infantile diarrhea,the combination of smecta and P.O. Bifidobigen can result in efficacy in addition to controlling its causes.
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Objective: To observe the role of Qudu medicinal granules (祛毒冲剂) on enterogenous endotoxemia . Methods: Sixty-one cases with enterogenous endotoxemia were randomly divided into two groups:Qudu medicinal granule group (n=30) that was treated with Qudu medicinal granules combined with western medicine, and smecta group which was treated with smecta and western medicine (n=31). Changes of symptoms and signs were observed before treatment and 1, 3, 7 days after treatment. Blood samples were collected in the morning to measure the white blood cell (WBC), plasma lipopolysaccharide (LPS) and tumor necrosis factor (TNF) levels. Results: Recovery speed of WBC count in Qudu medicinal granule group was faster than that of the smecta group, there was significant difference on the third day after treatment (P
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Objective To evaluate the effect of smecta on acute gastroenteritis induced by the radiotherapy in human cervical cancer.Methods seventy-eight patients under radiotherapy received smecta combined with general medicine to control gastroenteritis. All patients were divided into 2 groups:group A: 40 patients were treated with smecta and general medicine.group B:38 patients were only routinely treated. The routine medicine included prednisone, vitamin B 2 and ciprofloxacin.Results The effective rate for acute gastroenteritis in A group was significant higher than in B group ( P
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Objective To evaluate the effects of smecta in prolonged hemorrhagic shock.Methods The modified Wigger's method was used to induce hemorrhagic shock in anesthetized rabbits.Twenty-nine rabbits were randomly divided into hemorrhagic shock group(n=14),smecta group(n=15),with smecta solution being administered via a gavage tube before shock.The plasma levels of endotoxin,tumor necrosis factor ?(TNF?),interleukin-6(IL-6) and nitric oxide(NO) were detected at pre-shock and post-shock,immediately after resuscitation and 2h after resuscitation.Blood culture was done at pre-shock,immediately after resuscitation,2h after resuscitation.The survival rates of 24h and 48h were observed.Results The plasma levels of endotoxin,TNF?,IL-6 and NO markedly increased after shock,and were maintained at high level in shock group (P