Relationship between FGFR1 Gene Regulation of Circulating Tumor Cells and Clinical Features of Non-small Cell Lung Cancer / 中国肺癌杂志

BACKGROUND@#The methods of detection for recurrence and metastasis in patients with non-small cell lung cancer (NSCLC) have hysteresis and one-sidedness. This study summarizes the relationship between the circulating tumor cell (CTC) in peripheral blood, expression of fibroblast growth factor receptor 1 (FGFR1) and clinic pathological features in 30 patients with NSCLC so as to provide new ideas for the detection of tumor recurrence and metastasis.@*METHODS@#To analyze the clinical data and CTC detection data of 30 cases of NSCLC in Department of Thoracic Surgery, Peking Union Medical College Hospital from November 2016 to June 2017.@*RESULTS@#Data analysis showed that the positive rate of CTC in peripheral blood was remarkably correlated with the smoking history (P=0.016). There was no significant correlation among the pathological type and CTC positive rate and the expression of FGFR1 (P=0.202, P=0.806). There was no significant difference in the expression of FGFR1 in different type CTC cells (P=0.094).@*CONCLUSIONS@#The positive rate of CTC was significantly correlated with the smoking history of patients with NSCLC. There was no significant difference in CTC classification and FGFR1 expression in different pathological types of NSCLC. There was no significant difference in the expression of FGFR1 between different types of CTCs. We look forward to a larger sample size and inclusion of follow-up data to arrive at more clinically relevant conclusions about CTC and FGFR1 gene expression.

Chronic Smoking, a Cause for Development of Peripheral Neuropathy in Chronic Obstructive Pulmonary Disease.

Background: Cigarette smoking is the most commonly encountered risk factor for COPD, and causes COPD by its noxious particles and or gases. Cigarette smoke contains some neurotoxin substances that might be important in the pathogenesis of peripheral neuropathy. Objective: To determine whether the effect of the duration of smoking leads to development of peripheral neuropathy in different groups of the COPD patients as measured by nerve conduction studies of upper extremities Material and Methods: The nerve conduction test, of the median and ulnar nerves of the upper extremities, was performed on the subjects (study and control group), who were assessed for their anthropometric measurements, history regarding pack years, the pulmonary function tests, SpO2 levels. Results: Significant difference was found between smoking history in pack years and in the values of Nerve Conduction Velocity of the nerves of upper extremities in different groups of COPD patients, which was found to be statistically significant at p<0.001. Conclusion: A decrease in nerve conduction velocity was observed in the nerves of upper extremities as duration of smoking in pack years increased in the different groups of COPD patients.

The Effect of Smoking on the Serum Lipid Levels of Male White Collar Workers / 대한산업의학회지

This study was carried out to evaluate the relations between smoking and serum lipid levels in a group of 1,138 male white collar workers, ages 20 to 69 years. Smoking history on daily smoking amount, duration of smoking and duration of smoking cessation was obtained by questionnaire and was pack year. The levels of seurm lipid such as total cholesterol(TC), high density lipoprotein cholestoerol(HDL), triglyceride(TG), and low density lipoprotein cholesterol(LDL) were measured by enzyme method. We also observed the effects of various variables such as age, education, income, exercise, fasting blood suger, body mass index and alcohol. The correlation, ANOVA and multiple regression analysis were performed using SAS pakege programme. The results obtained were as follows; 1. Age was positively related to TC, TG and LDL; income was positively related to TC and LDL; exercise was positively related to HDL; body mass index was positively related to HC, TG and LDL and was inversely related to HDL; alcohol intake was positively related to HDL and TG. 2. TC, TG and LDL increased and HDL decreased significantly with increasing daily smoking amount, duration of smoking or pack year. 3. The differences found among the various groups by duration of smoking cessation were not significant for the adjust means of TC, HDL, TG and LDL. 4. Multiple regression analysis demonstrated that smoking contributed independently to all serum lipid levels of other variables such as age, education, income, exercise, body mass index, alcohol and fasting blood sugar. However, the contribution rate of smoking to the serum lipid levels was only 1-2%.