Clinical observation of silicone hydrogel soft contact lens in the treatment of persistent corneal epithelial defect / 国际眼科杂志(Guoji Yanke Zazhi)

@#AIM: To investigate the effect of silicone hydrogel soft contact lens in the treatment of persistent corneal epithelial defect. <p>METHODS: The clinical data of 56 patients(56 eyes)with persistent corneal epithelial defect treated in our hospital from January 2014 to January 2017 were retrospectively analyzed; 21 patients in the control group received hydrogel contact lenses, and 35 patients in the observation group received silicone hydrogel soft contact lens. Then the clinical effect, the classification of corneal opacity, the improvement of visual acuity, the subjective comfort and complications of the patients were recorded. <p>RESULTS: Wilcoxon rank sum test showed that there were significant differences in the clinical efficacy between the two groups(<i>P</i>=0.042). The total effective rate of the observation group was significantly lower than that of the control group(94% <i>vs</i> 76%). There was no significant difference in Haze classification between the groups after 3d of treatment(<i>P</i>>0.05); after 1wk and 1mo of treatment, there were significant differences in Haze classification between groups(<i>P</i><0.05); after 1mo of treatment, the proportion of Haze grading 0 in the observation group was significantly higher than that in the control group(49% <i>vs</i> 19%), there was significant difference between the two groups(<i>χ</i>²=4.481, <i>P</i>=0.027). There was a significant difference in visual acuity between the two groups(<i>Z</i>=-3.347, <i>P</i><0.05); the visual acuity of 91.43% in the observation group were improved, which was significantly lower than that of the control group(52.38%, <i>P</i>=0.002). There was no significant difference in the comfort scores between the two groups before treatment(<i>P</i>>0.05). After the first day of treatment, the comfort scores of both groups increased. The comfort scores of the observation group after treatment 1d, 3d and 1wk were significantly lower than those of the control group(<i>t</i>=-17.422, -15.827, -16.588; <i>P</i><0.01). The average healing time of corneal epithelium in the observation group was 4.25±1.05d, and the control group was 5.96±2.16d(<i>t</i>=-3.395, <i>P</i><0.05). The incidence of adverse reactions in the observation group was lower than that in the control group(<i>P</i><0.05). <p>CONCLUSION: Silicon hydrogel soft corneal contact lens can be used in the treatment of persistent corneal epithelial defect.

Clinical performance of Rose K2 soft contact lens for keratoconus / 国际眼科杂志(Guoji Yanke Zazhi)

AIM: To evaluate the comfort and visual performance of Rose K2 soft contact lenses in patients with keratoconus.METHODS: Fifty eyes of 50 participants were included in this cross-sectional study.Each participant received a full ophthalmologic examination involving refraction,uncorrected visual acuity (UCVA),best spectacle corrected visual acuity (BCVA),slit-lamp biomicroscopy-fundoscopy,break-up time (BUT),corneal topography,and contrast sensitivity.After contact lens was fitted best contact lens corrected visual acuity (BCLCVA),contrast sensitivity,and comfort rating via visual analogue scales (VAS) were performed.RESULTS: The mean age was 26.2±6.0 (range: 16 to 39)y.The mean logMAR UCVA,BCVA,and BCLCVA with Rose K2 soft (in order) were 0.61±0.37 (range: 0.15-1.3),0.42±0.32 (range: 0-1.3),and 0.18±0.20 (range: 0-1.3).There were significant increases in visual acuities with contact lenses (P < 0.05).The mean contrast sensitivity scores were significantly better with both contact lens in mesopic and photopic conditions (P <0.05).The mean VAS score was 8.02±1.64 (range: 5-10) for Rose K2 soft.CONCLUSION: Rose K2 soft contact lens can improve visual acuity,contrast sensitivity with comfort in patients with keratoconus.

Corneal histopathology changes of the soft contact lens long-time wearers / 国际眼科杂志(Guoji Yanke Zazhi)

AIM:To investigate the corneal histopathology changes induced by soft contact lenses ( SCL) at diffent time. METHODS: Central and peripheral cornea structures of myopic patients wearing SCL (150 cases) and the control goups ( 150 cases ) were observed with confocal microscopy. The examinations were performed 1, 3, 5, 8 and 10a after contact lenses wearing respectively. RESULTS: After wearing the contact lenses for 5a, the cell density of corneal surface epithelial was lower in SCL wearers compared with control goups (P0.05). The SCL wearers showed a thinner thickness of central corneal epithelium than control group (P<0. 05).CONCLUSION: The corneal morphologic changes are more obvious with the longer time, and the changes is not ignored.

Biometric Risk Factors for Corneal Neovascularization Associated with Hydrogel Soft Contact Lens Wear in Korean Myopic Patients

PURPOSE: To investigate the biometric risk factors for corneal surface complications associated with hydrogel soft contact lens (SCL) fitting in myopic patients in Korea. METHODS: This is a retrospective case-control study. The records of 124 subjects (124 eyes) who wore SCLs on a daily basis were reviewed. Thirty-one patients (31 eyes) who were diagnosed with corneal neovascularization (NV) while wearing SCLs were included in the complication group. Ninety-three age- and sex-matched patients (93 eyes) who wore SCLs, who did not have corneal NV and who visited our clinic for correction of refractive errors were included in the control group. The degree of spherical equivalent, astigmatism and corneal base curve radius (BCR) were compared in both groups. RESULTS: Patients with NV exhibited poorer best corrected visual acuity and more myopia than controls (p = 0.008 and 0.006, respectively). In univariate analysis, highly myopic patients (-9 diopters [D] or higher) were more likely to experience NV (odds ratio [OR], 2.232; 95% confidence interval [CI], 1.602 to 3.105). High astigmatism (> or =2 D) increased the risk of complications (OR, 2.717; 95% CI, 1.141 to 6.451). Steep cornea, in which BCR was <7.5 mm, also raised the risk of complications (OR, 4.000; 95% CI, 1.661 to 9.804). Flat cornea was not a risk factor for the development of NV. CONCLUSIONS: High myopia, high astigmatism, and steep cornea seemed to be risk factors in the development of corneal NV in SCL wearers.

Clinical Features and Compliance in Patients with Cosmetic Contact Lens-Related Complications

PURPOSE: To investigate the clinical features and compliance of cosmetic contact lens (CL)-related complications compared with soft CL-related complications. METHODS: We performed a retrospective chart review of 97 patients (194 eyes) regarded as having CL-related complications at the outpatient clinic. The portion of complications, gender, age, and chief complaints at the initial visit were analyzed, as was compliance to cosmetic and soft CL-related guidelines for use. RESULTS: A total of 97 patients (49 patients with cosmetic CL-related complications and 43 patients with soft CL-related complications) were evaluated. The mean age of the subjects using cosmetic CL was 19.8 years (14-31 years), and all the patients were female. The chief complaints at the initial visit included ocular pain, injection, blurred vision, dryness, itching and foreign body sensation. The main complications included corneal erosion, sterile corneal infiltrate, allergic disease, neovascularization, corneal ulcer and dry eye syndrome. No statistical difference was found regarding chief complaints or complications. The proportion of patients lost to follow-up was 47% in cosmetic CL-related and 20% in soft CL-related complications, a significant difference (p = 0.015). CONCLUSIONS: Because young females are the most common CL patients and do not always fully comply with the guidelines for use, ophthalmologists need to warn these patients about the risk of serious complications.

Contact lens in keratoconus.

Contact lenses are required for the visual improvement in patients with keratoconus. Various contact lens options, such as rigid gas permeable (RGP) lenses, soft and soft toric lenses, piggy back contact lenses (PBCL), hybrid lenses and scleral lenses are availble. This article discusses about selection of a lens depending on the type of keratoconus and the fitting philosophies of various contact lenses including the starting trial lens. A Medline search was carried out for articles in the English language with the keywords keratoconus and various contact lenses such as Rose k lens, RGP lens, hybrid lens, scleral lens and PBCL.

Retained soft contact lens masquerading as a chalazion: A case report.

A misplaced contact lens is a common ocular emergency presenting to the eye casualty. We report a case of lost soft contact lens which migrated in the lid and presented 13 years later with symptomatic eye lid swelling. Authors in the past have reported migration and subsequent retention of lost hard lenses in locations such as the superior fornix and eyelid. To the best of our knowledge, misplaced soft contact lens masquerading as a chalazion has not been reported in the literature. Consideration should be given to the possibility of a retained contact lens in a patient with a history of a lost or misplaced lens, and examination of the ocular surface with double eversion of the upper lid should be performed.

Investigation of soft contact lens related knowledge and wearing behaviors / 现代临床护理

Objective To investigate the soft contact lens related knowledge and wearing behaviors.Method Two hundred outpatients in the ophthalmologic clinic wearing SCL involved in the survey by the questionnaire to investigate the SCL-related knowledge and the wearing behaviors.Results In the 200 SCL wearer,73.50% did not make any examinations by specialists and only 18.00% of them took regular examinations.The wearers were good at the knowledge of selecting SCL diopter and positive and negative lens.The wearers with a history of less than 6 months were better than those wearing SCL more than 6 months in respect of hand cleaning,lens check,lens wearing, and lens cleaning.The wears with the education of two-year vocational training were significantly better than those with the education of three-year or more collegiate training in respect of wearing duration,sleep with lens,hand cleaning and lens cleaning(all P<0.05).Conclusion Contact lens wearers know less about SCL related knowledge and their wearing behaviors needs improvement.

Effects of different contact lens correction on Zernike aberrations of human eye / 中华实验眼科杂志

Background Even though the change in wavefront aberrations with correction modality is well documented in the literature,little is known about the underlying mechanism.Complete understanding of the causes responsible for the wavefront change in the combined lens-eye system is important since it provides basic knowledge for further improving the technique to correct refractive error by correcting lenses.Objective The aim of this study was to investigate the influence of refractive correction lens on optical property of the eye by analyzing Zernike aberrations in myopic eyes with contact lens correction.Methods This study was approved by the Ethic Committee of Wenzhou Medical College.Written informed consent was obtained from each subject before entering this study.Zernike aberrations of 52 myopic eyes of 26 subjects with the spherical equivalent-1.75 to-8.50 D were measured using a Hartmann-Shock wavefront sensor.The human eye aberrations were examined at the uncorrected condition,rigid-gas-permeable contact lens (RGP-CL) corrected condition and soft contact lens (Soft-CL) corrected condition.The differences of wavefront aberrations and Zernike coefficients were compared by repeated measurement of single factor variance analysis,and correlation of the aberration changes between uncorrected condition and RGP-CL corrected condition or Sofi-CL corrected condition,between the right eyes and left eyes in different conditions were analyzed by Pearson linear correlation.Results Mean total root-mean-square (tRMS) was (0.71 ± 0.30)μm,(0.54±0.19)μm and (0.74±0.32)μm in the uncorrected condition,RGP-CL corrected condition and Soft-CL corrected condition,with a significant difference (F =8.758,P＜0.001),and tRMS was significant declined under the RGP-CL corrected condition compared with uncorrected condition (t =2.746,P =0.008),and tRMS in RGP-CL corrected condition was significantly lower than that in Soft-CL corrected condition (t =3.428,P =0.001).The high RMS (hRMS) was (0.34±0.12) μm,(0.28 ±0.12) μm,(0.40±0.14) μm in the uncorrected condition,RGP-CL corrected condition and Soft-CL corrected condition,with a significant difference among them (F =10.681,P＜0.001).An insignificant decrease of hRMS was seen in the RGP-CL corrected condition compared with uncorrected condition (t =1.987,P=0.053),but hRMS value was significant higher in the Soft-CL corrected condition than that in the uncorrected condition (t=2.101,P=0.041) and RGP-CL corrected condition (t=4.266,P＜0.001).Compared with uncorrected condition,the axis astigmatism (C5) and spherical aberration (C12) in the RGP-CL corrected condition and spherical aberration (C12) in the Soft-CL corrected condition were significantly reduced (P＜0.05),and the absolute values of trefoil (C6),vertical coma (C7) and tetrafoil (C10) in the RGP-CL corrected condition were lower than those of the uncorrected condition,but vertical coma (C7) absolute value in the Soft-CL corrected condition was increased (P＜0.05).A significantly positive correlation was seen in the spherical aberration (C12) between the RGP-CL corrected condition and uncorrected condition (r =0.763,P＜0.001),and less significant correlation was in the secondary astigmatism (C11) between the Soft-CL corrected condition and uncorrected condition(r=0.469,P＜0.001).Conclusions Different contact lens corrected conditions exert their effects on ocular wavefront structure due to its unique interaction with the eye.RGP-CL wearing has strong modification on wavefront aberrations probably due to its molding effect on corneal surface,which reduces the bilateral symmetry.High order wavefront aberration can be modified by Soft-CL wearing.

Effect of wearing of soft corneal contact lens for long term on apoptosis of corneal epithelial cell / 中华实验眼科杂志

Background Wearing of soft contact lens,as one of the important methods to correct ametropia,has been widely applied at present.The clinically deleterious effects of soft contact lens have been reported,but researches about influence of apoptosis of corneal epithelial cells are scant.Objective This study was to detect and compare the ratio of apoptosis of corneal epithelial cells between the patients with contact lens wearing and without contact lens wearing,and explore the influence of soft contact lens wearing for long term on growth of corneal epithelial cells after injury.Methods A retrospective nest case-controlled study was designed.Forty eyes of 20 myopic patients with wearing of soft contact lens for ≥5 years and 40 eyes of 20 myopic patients without wearing of soft contact lens were included in Affiliated Hospital of Guiyang Medical College.All the patients received the off-flap epipolis laser in situ keratomileusis (Epi-LASIK) from 2010 October to 2011 June.The corneal flaps were collected during the surgery.The apoptosis of corneal epithelial cells was detected by flow cytometry(FCM),and the difference of apoptotic proportion between the two groups was compared using independent sample t test.Results The FCM scatter plot showed that compared to the without contact lens wearing group,the early stage of apoptotic cells with high staining annexin V and low staining proaium iodide (PI) were much more,and survival cells with low staining annexin V and PI were less,and necrotic and late stage of apoptotic cells with high staining of annexin V/PI were more in the with contact lens wearing group.The early stage of apoptosis proportion of corneal epithelial cells was (11.23 ± 5.31)％ in the with contact lens wearing group,and that in the without contact lens wearing group was (7.31± 5.43)％,showing a significant difference between them (t=2.754,P=0.008).Conclusions A long term wearing of contact lens induce more apoptosis of corneal epithelial cells,which can result in a disorder of structure and function of ocular surface during the wound healing stage.

Intraocular Pressure Measurement with the Noncontact Tonometer and Rebound Tonometer through Plano Soft Contact Lenses

PURPOSE: To investigate the accuracy of intraocular pressure (IOP) measurement through a plano soft contact lens (SCL) in situ by a noncontact tonometer (NCT) and a rebound tonometer (RBT). METHODS: The IOP of 66 eyes of 33 subjects with no ocular pathology was measured by NCT (tonometer CT-80, TOPCON, Japan) and RBT (iCare rebound tonometry(TM), Tiolat Oy, Finland). IOP measurement was repeated through plano SCL (ACUVUE OASYS(R), Johnson & Johnson Vision Care Inc., USA) in situ. Statistical analysis was performed using the paired t-test. RESULTS: Mean IOP measured by NCT was 13.10 +/- 2.52 mmHg without SCL and 12.95 +/- 2.56 mmHg with SCL. Mean IOP measured by RBT was 14.13 +/- 2.94 mmHg without SCL and 13.84 +/- 2.75 mmHg with SCL. No significant statistical differences were found between IOP measured with and without SCL (p=0.47, p=0.11 respectively). CONCLUSIONS: Reliable measurement of IOP by NCT and RBT can be achieved through plano SCL.

Changes in Tear Film, Cornea and Ocular Surface According to the Duration of Soft Contact Lens Wear

PURPOSE: The present study evaluated the changes in tear film, cornea and ocular surface according to the duration of soft contact lens wear. METHODS: A total 65 patients with 130 eyes were enrolled the present study, and were divided into 4 grous. The control group (group A) was composed of 32 eyes of 16 patients who had not worn soft contact lenses, group B, (34 eyes of 17 patients), had worn soft contact lenses less than 5 years, group C, (32 eyes of 16 patients), had worn soft contact lenses for 5 to 10 years and group D, (32 eyes of 16 patients), had worn soft contact lenses for more than 10 years. The tear break-up time (BUT), Schirmer's test, corneal sensitivity test, central corneal thickness, ocular surface disease index (OSDI), corneal fluorescein staining score, specular microscopy and conjunctival impression cytology were analyzed. The results were compared between the control group and the soft contact lens groups. RESULTS: In group B, BUT significantly decreased, but corneal fluorescein staining score and squamous metaplasia significantly increased (p < 0.05). In group C, OSDI and snake-like chromatin pattern significantly increased, but corneal thickness and goblet cell density significantly decreased (p < 0.05). In group D, the coefficient of variation for endothelium significantly increased, but corneal sensitivity and hexagonality significantly decreased (p < 0.05). CONCLUSIONS: Duration of soft contact lens wear influences changes in tear film, cornea and ocular surface.

Cosmetic Contact Lens-related Complications: 9 Cases

PURPOSE: To report the complications resulting from incorrect use of cosmetic contact lenses. CASE SUMMARY: The medical records of 9 patients with complications related to cosmetic contact lenses were retrospectively reviewed. All 9 patients had corneal erosion, and 2 patients had corneal epithelial defects. Corneal neovascularization more than 2 mm from the limbus was observed in 3 patients and one of the patients received a permanent impairment of visual acuity. Seven patients were not educated on the management of contact lenses and 2 patients had previous experience using contact lenses. None of the patients acquired any information or proper instructions regarding their cosmetic contact lenses. During the follow-up examination, 5 out of 6 patients had symptom relief after: 1) discontinuance of using the cosmetic contact lenses or 2) proper education of contact lens use with topical antibiotics and artificial tears. CONCLUSIONS: Many cosmetic contact lens users have insufficient information on usage of contact lenses. Providing proper education to cosmetic contact lens users is very important. Cosmetic contact lens users should have ophthalmic checkups on a regular basis. In addition, illegal production and sales of cosmetic contact lenses must be strictly regulated to prevent complications caused by inferior products.

Effectiveness of Multifocal Soft Contact Lens for Presbyopia

PURPOSE: To assess the effect of multifocal soft contact lenses on the correction of visual acuity in patients with presbyopia. METHODS: Forty-four patients ranging from 45 to 60 years of age visited the Department of Ophthalmology at St. Mary's Hospital and the Department of Ophthalmology at Korea University's Anam Hospital between August 2005 and February 2006. The visual acuity of patients who used Morning QI-plus (multifocal soft contact lenses, Interojo, Republic of Korea) was analyzed at, before, and immediately after correction, then one week and one month after correction. Symptoms that developed after Morning QI-plus application, slit lamp microscopy results, and patient satisfaction were quantified into scores and compared. RESULTS: Far and near visual acuity before correction were 0.240+/-0.432 and 0.415+/-0.227, respectively. They were 0.025+/-0.048 and 0.118+/-0.094 immediately after correction was initiated, 0.019+/-0.046 and 0.102+/-0.055 after one week, and 0.015+/-0.042and 0.111+/-0.086 after one month. Both far and near visual acuity showed statistically significant improvement after correction (p<0.05). CONCLUSIONS: After correction, visual acuity improved by more than 2 Snellen lines in 84.1% of patients. We conclude that multifocal soft contact lenses are effective for presbyopia.

A Case of Acinetobacter Baumannii Keratitis After Contact Lens Wearing

PURPOSE: To report a case of Acinetobacter baumannii keratitis in a soft contact lens wearer. To our knowledge, such a case has not been previously reported in South Korea. CASE SUMMARY: A 17-year-old boy who had worn soft contact lens for 4 months came to our hospital complaining of severe ocular pain, glare, and visual disturbance in his left eye for 2 days prior to admission. On slit-lamp examination, a round 2.5x4.5 mm lesion with epithelial defects and diffuse edema was noted. Numerous keratic precipitates and hypopyon on the dependent position were also noted. Specimens from corneal scraping, the contact lens itself, and the storage case with lens cleanser solution were evaluated by bacteriology examination. The patient was treated with topical 0.5% Moxifloxacin. A few days later, Acinetobacter baumannii was isolated in a bacterial culture from a corneal specimen. The patient's clinical features improved steadily with topical 0.5% Moxifloxacin therapy. Complete epithelialization with resolution of the corneal edema and inflammatory infiltrations of the left eye was achieved after 5 days of topical Moxifloxacin therapy. CONCLUSIONS: Along with a literature review, we report a case of successfully treated Acinetobacter baumannii keratitis in a soft contact lens wearer.

Corneal Neovascularization and Corneal Hypesthesia as Contact Lens Complications

PURPOSE: To investigate the relationship between corneal neovascularization (CNV), corneal hypesthesia and dry eye syndrome. METHODS: From July 2003 to November 2004, patients who had history of weraing soft contact lenses were selected and administered the Schirmer test; those with conjunctival inflammation and corneal complications were tested using an esthesiometer, and were given a dry eye questionnaire. RESULTS: A longer period of soft contact lens wear was related to CNV and corneal hypesthesia (p<0.01), and theses two complications showed a significan relationship with symptoms of dry eye syndrome (p<0.01). CONCLUSIONS: Corneal neovascularization and corneal hypesthesia should be considered in cases of long term wear of soft contact lenses. The eyes with CNV and corneal hypesthesia had more severe symptoms of dry eye syndrome.

Effects of soft contact lenses on corneal diseases / 第三军医大学学报

Objective To evaluate the therapeutic efficacy of soft contact lenses on corneal diseases. Methods A total of 70 cases (82 eyes) of corneal diseases in the treatment group were treated with therapeutic soft contact lenses combined with topical antibiotic eye drops and artificial tears, but 64 cases (81 eyes) suffering from corneal diseases in the control group were treated with eye drops and eye ointments. ? 2 test was used to compare the cure rate of corneal epithelial defects and corneal ulcers caused by chemical and thermal burns between the two groups. Double sample t test was used to compare the average treatment time between the two groups. Results The cure rates of the corneal epithelial defects and corneal ulcers caused by chemical injury and thermal burn in the treatment group and the control group were 83% and 57%, respectively. In the treatment group, 100% patients with bullous keratopathy and 90% patients with dry eye disease were free from symptoms after wearing the lenses, but in the control group, the percentages were 50% and 63.6%, respectively. In the treatment group, 3 cases (4 eyes) of corneal epithelial defects caused by explosive injury and 3 cases of corneal epithelial defects after lameller keratoplasty were all cured, and 4 cases(4 eyes) of corneal perforations were healed. In the control group, 1 out of the 2 cases of corneal epithelial defects caused by explosive injury was cured, and 4 cases of corneal epithelial defects after lamellar keratoplasty surgery were cured, but 2 cases (2 eyes) of corneal perforation failed in the therapy, and corneal surgery was performed. In the treatment group, the cure rates of corneal epithelial defects or corneal ulcers caused by chemical injury and thermal burn were significantly higher than those in the control group ( P

A Comparison of Anti-Pseudomonal effects by Multi-purpose Contact Lens Solutions

PURPOSE: To compare the antimicrobial effects of various kinds of multi-purpose solutions, study effective ways of washing contact lens (CLs), and suggest the most effective lens care system using P. aeruginosa-contaminated CLs. METHODS: Each disposable soft CL was incubated in 0.1 ml of diluted solution of P. aeruginosa standardstrain (10(8)CFU / mm(3)) and 0.9 ml tryptic soy broth in cell culture wells for 24 hours. In the first experimental group, to find the most antimicrobial solution, 40 CLs contaminated by P. aeruginosa were divided into four subgroups washed with four different kinds of multi-purpose solutions. Ten CLs were used in each subgroup and in the control group; Ten CLs contaminated by P. aeruginosa were washed with phosphate buffered saline (PBS) instead of cleaning solution. In the second experiment groups to find the most effective way of washing, using only Renu Multiplus multi-purpose solutionR we compared the antimicrobial effect of four different ways of washing including 30 seconds rubbing, 30 minutes soaking, 4 hours soaking, 30 seconds rubbing and 4 hours soaking. RESULTS: There was no significant difference of antimicrobial effect between four kinds of multi-purpose solutions. All methods have a significant antimicrobial effect over control group (P<0.001) and the most effective method of washing CLs was 4 hours soaking. CONCLUSIONS: we should advise all the soft CL users that they should have their CLs soaked over 4 hours everyday after wearing it.

Treatment of bullous keratopathy with soft contact lens / 眼科新进展

Objective　To assess the roles of the soft contact lens(SCL) in the treatment of bullous keratopathy.Methods　Seventeen cases with bullous keratopathy wore SCL continuously and disposed it each month. All cases were followed up to observe whether the clinical symptoms were relieved and complications appear.Results　 Seventeen cases were followed up for 2 to 22 months. The results suggested that the clinical symptoms were relieved significantly without complications.Conclusion　SCL can relieve the clinical symptoms and improve the life quality of patients with bullous keratopathy significantly.

Morphology and Ultrastructure of Microorganisms on Soft Contact Lens :Scanning Electron Microscopic Study

In order to examine the morphology and ultrastructure of contaminated soft contact lens by scanning electron microscopy, soft contact lenses were contaminated with P.aeruginosa, S.aureus, S.epidermidis and C .albicans. After incubation of soft contact lens in P.aeruginosa suspension for 60 minutes, a number of P.aeruginosa, S.aureus and S.epidermidis were attached to soft contact lens and amorphous materials covering the some of the soft contact lens surface were observed. Also, C.albicans attached to soft contact lens, looking like healthy and the fine fibrillar material covered the surface of soft contact lens and interconnected between cell walls of C.albicans at 14 days after contamination. Soft contact lens may provide a suitable environment for microorganisms that they could attach and proliferate. And microoragisms themselves secreted amorphous materials to protect them from the outside and promote the proliferation. So, contaminated soft contact lens may play a role as pathogen to the cornea.