ABSTRACT
A series of heterocyclic schiff bases have been synthesised by the condensation of 2-amino-4,6- dimethyl benzothiazole and selected heterocyclic α- hydroxy aldehyde and α-hydroxy ketones. The structures of the products were confirmed by spectral analysis (IR, 1H NMR, 13C NMR and Mass). All the newly synthesized compounds were screened for their antibacterial and antifungal activity against different fungal and bacterial strains.
ABSTRACT
This study was aimed to evaluate the in vitro complexation nature and strength of complex which may be formed due to interaction between Amoxicillin and Calcium chloride (CaCl2). The interaction of Amoxicillin and Calcium chloride (fused) has been studied in aqueous systems at a fixed temperature (37 ± 0.5) °C and under different pH (pH 2.4 and pH 7.4) by using some physical methods as spectral observation, Job’s method of continuous variation, Ardon’s method. From spectrophotometric study, Amoxicillin gives a sharp peak at 272 nm when Calcium chloride mixed with Amoxicillin in 1:1 ratio the intensity of the peak of Amoxicillin change remarkably due to interaction. The jobs plot was obtained by plotting absorbance difference against the mole fraction of the each drug at pH 2.4 and pH 7.4. Amoxicillin forms strong 1:1 complex with Calcium chloride and reverse V Shaped curves indicate the formation of 1:1 complexes of Amoxicillin with Calcium chloride. These may indicate strong kinetics of complexation between Amoxicillin with Calcium chloride. The value of stability constant for the complexation of Amoxicillin with calcium chloride at pH 2.4 and pH 7.4 were obtained from the spectral data using Ardon’s plot. The value of stability constant for the drug-metal system at pH 2.4 and pH 7.4 are 5.54 and 6.67 respectively. At pH 2.4 it is found that Amoxicillin form relatively stable complex with Calcium chloride (stability constant 6.67) is high in comparison to pH 7.4. It can therefore be concluded that a careful consideration is needed during concurrent administration of Amoxicillin with Calcium chloride.
ABSTRACT
The new acyclic Schiff base [L] ligand: 3,3'-(1E,1'E)-1,1'-(2,2'-azanediylbis (ethane-2,1- diyl)bis(azan-1-yl-1-ylidene))bis(ethan-1-yl-1-ylidene) bis(4-hydroxy-6-methyl-2H-pyran-2-one) derived from condensation of one mole diethylene diamine triamine (dien) with two moles of dehydroacetic acid have behaved tetra dentate dibasic chelating agent with all metal ions under study. Three bimetallic Cr(III), Co(II) and Fe(III) acyclic polydentate complexes [M2L2Cl2]Cl4 ,M=Cr(III) , Fe(III) and [M2L2Cl2], M=Co(II) have been prepared and fully characterized by UV-Vis., FTIR, micro-elemental analysis , as well as the magnetic moments of solid complexes and the measurements of molar conductance in DMSO solution helped us in investigate the chemical structure of bimetallic models . From the results obtained by different techniques, it was found that the proposed structures of the prepared complexes have octahedral structure. A theoretical treatment of the formation of complexes in the gas phase was studied, this was done using the HYPERCHEM-6 program in general. The synthesized compounds were tested for antimicrobial activity by cup plate diffusion method. The results indicate the enhanced activity of metal complexes over the parent ligands.