ABSTRACT
Nasal spray can treat local diseases such as rhinitis, it also plays an important role in the treatment of systemic diseases including vaccine immunity. As a drug-device combination product, spray pattern is often used as the quality indicator of nasal spray to ensure its quality, plume geometry can not only be combined with the spray pattern to evaluate the performance of the nasal spray, but also can predict the deposition of the nasal spray in the nasal cavity. This article systematically reviews the definition and measurement methods of the spray pattern and plume geometry of nasal spray and their correlation with nasal deposition behavior. The measurement parameters of spray pattern and plume geometry are defined. The influence of formulation, device and trigger parameters on spray pattern and plume geometry is clarified. The correlation between various parameters and nasal deposition is analyzed. The measurement parameters are classified according to the size and shape of the spray. Plume angle is closely related to the deposition of drugs in the nasal cavity. Jet-like plume with a smaller plume angle can increase the navigation ability of the nasal spray in the curved anatomical structure of the nasal cavity, which is conducive to increase drug deposition. This makes it possible to increase deposition of the nasal spray in the nasal cavity via appropriately increasing viscosity and thixotropy of the nasal spray formulation. This review provides the theoretical basis for the high quality nasal spray product development.
ABSTRACT
It is very important to develop nasal sprays with higher bioavailability and better targeting capability by making further use of advanced technology and new methods according to its characteristics. Intensive research has been searched on nasal sprays quality control methods which have been developed in the last few years. This review discusses the critical quality attributes of nasal sprays and the research progress of the quality control methods. Clarifies the characters examine of the nasal spray (pH, osmolality, particle size distribution and viscosity), content and related substances, packaging materials compatibility studies, spray pattern and droplet distribution methods of quality control.
ABSTRACT
Solid dosage forms are coated for a number of reasons, the most important of which is controlling the release profiles and bioavailability of the active ingredient. The amount of coating on the surface of a tablet is critical to the effectiveness of the oral dosage form. Tablets are usually coated in horizontal rotating pans with the coating sprayed onto the free surface of the tablet bed. Tablets must have a coating mass that lies within a prescribed range with very little inter- and intra-tablet coating variability. Using the Discrete Element Method (DEM), tablet coating can be simulated on the computer. Simulation data provide the position, velocity, and orientation of each tablet within the coater, allowing accurate measurements of the time and orientation that each tablet spends exposed to the coating spray.