ABSTRACT
Resumen: Las lesiones raquimedulares producidas por arma blanca son poco frecuentes, pero constituyen hasta un 10% de las lesiones penetrantes espinales. Se presentan tres casos de lesiones raquimedulares causadas por arma blanca, se trata de dos mujeres y un hombre que recibieron agresiones con cuchillos a nivel del dorso. Una lesión fue a nivel torácico y dos a nivel cervical. Se trataba de lesiones medulares incompletas y recibieron un manejo conservador. La evolución fue buena en dos pacientes y mala en uno, que requirió en diferido asistencia respiratoria mecánica y agravó su déficit motor (cuadriparesia a prácticamente una cuadriplejia). En base a estos casos, los autores hacen una revisión del tema y plantean un esquema de manejo diagnóstico y terapéutico para las lesiones raquimedulares penetrantes no causadas por arma de fuego.
Abstract Spinal cord injuries are rare, but constitute up to 10% of spinal penetrating lesions. There are three cases of spinal cord injury, two women and one man who were attacked by knives at the level of the back. One injury was at the thoracic level and two at the cervical level. They were incomplete medullary lesions and received conservative management. The evolution was good in two patients and poor in one, which required a delayed mechanical ventilation and aggravated its motor deficit (quadriparesis to practically a quadriplegia). Based on these cases, the authors make a review of the subject and propose a diagnostic and therapeutic management scheme for penetrating spinal cord injuries not caused by firearms.
ABSTRACT
Aim To investigate the effects of osthol on cell apoptosis and inflammatory cell infiltration after brain stab wound injury in mice. Methods The mice underwent the stab wound injury by a needle, then were randomly divided into sham operation group, model group, osthol 10, 20, 30 mg · kg-1 treatment group. The main examinations included mice brain wa-ter content; the apoptotic cytokines Bax, Bcl-2, Caspase-3 mRNA expression were assessed by PT-PCR; immunohistochemistry staining was used to de-tect neutrophils (MPO) and microglia (Iba-1) infiltra-tion and Caspase-3 positive cell expression around in-jured lesions. Results Treatment with osthole 20, 30 mg·kg-1 group significantly reduced the water content in injured brain, improved the ratio of Bax/Bcl-2, and reduced the expression of apoptosis cytokine Caspase-3 mRNA. Osthole 30 mg·kg-1 treatment group obvious-ly reduced the infiltration of neutrophils and microglial cells and significantly reduced the number of apoptotic cells around the injured cerebral cortex. Conclusion Osthole has therapeutic effect on stab wound injury in mice, and the possible mechanism may be by reducing the infiltration of inflammatory cells and reducing apop-totic cells.