Sequential Cases of Staphylococcal Scalded Skin Syndrome in Very Low Birth Weight Infants

Staphylococcal scalded skin syndrome (4S) is an exfoliative skin disease caused by Staphylococcus aureus toxins. 4S usually has a benign course in young infants and children; however, it could be fatal in preterm infants, especially very low birth weight infants. We experienced two sequential 4S cases that occurred in the neonatal intensive care unit. One of the patients had complications such as bacteremia and acute kidney injury.

Clinical Review of Staphylococcal Scalded Skin Syndrome in a Single Institution for 18 Years, 2001–2018 / 계명의대학술지

Staphylococcal scalded skin syndrome (SSSS) is a disease caused by exfoliative toxin. The purpose of this study is to analyze clinical features, laboratory findings and treatment outcome of patients who diagnosed with SSSS in a single institution for 18 years. From January 2001 to December 2018, 137 patients were diagnosed with SSSS at Daegu Fatima hospital. We retrospectively reviewed the 131 patients' medical records except 6 patients who were unable to identify the exact medical records. The median age of the patients was 32 months (5 days to 97 months) and 78% of the patients were under 4 years. The mean annual number of cases was 7.3 ± 3.7, the number of patients was increased since 2013, and occurred mainly from August to January. Skin cultures were performed in 62 patients and methicillin-resistant Staphylococcus aureus was cultured in 37 patients. The result of the treatment was good without the dead patient. SSSS is a disease occurred frequently in young children, at August to January. The number of patients was increased since 2013. MRSA was cultured a lot, but uniform use of glycopeptide is not necessary.

Regional outbreak of staphylococcal scalded skin syndrome in healthy children / 소아과

PURPOSE: Staphylococcal scalded skin syndrome (SSSS) is a relatively uncommon superficial blistering skin disease that is due to Staphylococcus aureus. We had experienced a regional outbreak of SSSS over 3 years in healthy children. METHODS: We retrospectively reviewed the medical records of those patients diagnosed as SSSS. Most of neonatal cases were nosocomial infections and excluded from the analysis. The clinical features, laboratory findings, the isolation and antibiotic resistance of S. aureus, the antibiotic management and other supportive treatments were analyzed. RESULTS: Fifty-five patients with SSSS were admitted to our hospital from October 2001 to September 2004. The median age of patients was 3.0 years. Of the 55 patients, 9 were the generalized type, 13 were the intermediate type and 33 were the scarletiniform rash. All the patients were living in neighborhood of the Jinju area. S. aureus were isolated from 9 of the patients and all of the isolated S. aureus were methicillin resistant. All the patients except two were treated with intravenous flocloxacillin or nafcillin and/or cefotaxime. All the patients recovered during the follow-up period of 2 to 3 weeks. CONCLUSION: We experienced a regional outbreak of SSSS in previous healthy children. Further study for finding the carriers of S. aureus caused SSSS and preventing the spread of this disease is needed. Additionally, guidelines for treating SSSS due to methicillin resistant S. aureus should be established.