MUTAGENESIS OF STREPTOMYCES HYGROSCOPICUS NND-52 PRODUCING AZALOMYCIN B / 微生物学通报

Streptomyces hygroscopicus NND 52 producing Azalomycin B was treated with UV,UV+LiCl,acridine orange,the best treatment dose was determined. The yields of several strains which were obtained were more than three times thaat ofCK, and the yield of strain A13 was 1100mg/L,they were stable.Through comparing the treating methods, it was shown that the later two methods were more effective