A Case of Pelvic Lymph Node Metastases in Cervical Carcinoma with Early Stromal Invasion / 대한산부인과학회잡지

The definition and management of microinvasive cervical cancer varies from time to time depending on the organization involved and is a persistent focus of controversy. The purpose of defining microinvasion is to identify a group of patients who are not at risk of lymph node metastases or recurrence and who therefore may be treated with less than radical therapy. Microinvasive cervical cancer with

Tumor diameter, tumor volume, cervical stromal invasion as prognostic factors in early stage cancer of the cervix

The surgical specimens of ninety-eight patients with cervical carcinoma Stage IB to IIA who underwent radical hysterectomy with pelvic lymphadenectomy at the Philippine General Hospital from February, 1990 to August, 1992 were examined tod etermine tumor diameter, tumor volume, and cervical stromal invasion for the purpose of determining 1) the interrelationship of tumor diameter, tumor volume and cervical stromal invasion; 2) the use of the above factors to predict lymph node metastasis and tumor recurrence; 3) the use of these three prognostic variables plus lumph node metastasis to predict recurrence rate; 4) to detemine the relationship between lymph node involvement and recurrence rateUsing multivariate dicriminant analysis, the following were noted: 1) There is a very significant positive relationship among the three prognostic factors, 2) Among the three variables, only tumor diameter and stromal invasion were significant in predicting lymph node metastasis. 3) All these three variables - tumor diameter, tumor volume and cervical stromal invasion have significant relationship with tumor recurrence. 4) The presence of lymph node involvement, when added to the three variables mentioned, contributed significantly in predicting recurrence rate. Using chi-square test, 5) the presence of lymph node metastasis significantly correlates with tunor recurrence.

Malignant Endometrioid Adenofibroma of the Ovary: A case report

Ovarian endometrioid adenofibroma is rare and characterized by prominent stroma. Its histologic classification is controversial but the malignant counterpart is distinguished from the borderline by the presence of confluent growth pattern of epithelium with invasion of the stroma by the endometrioid cells. A fifty-year-old woman was admitted with one month history of abdominal enlargement. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed under the clinical diagnosis of ovarian malignancy. Grossly, the righy ovary had round, encapsulated, solid and whitish gray mass which measured 9 cm in the greatest dimension and showed peripheral small cysts. Microscopic examination revealed that the tumor consisted of endometria type glands set in fibrous stroma. The glands varied from tubules to cysts and the lining cells showed complicated architectural pattern with occasional papillary infoldings, atypical mitosis and malignant nuclear characteristics. Some cysts of glands showed intraluminal mucin products. Stromal invasions by individual epithelial cells showing malignant characteristics were often found. A brief summary of the histopathologic aspect of this tumor is presented together with review of literatures.

Malignant Endometrioid Adenofibroma of the Ovary: A case report

Ovarian endometrioid adenofibroma is rare and characterized by prominent stroma. Its histologic classification is controversial but the malignant counterpart is distinguished from the borderline by the presence of confluent growth pattern of epithelium with invasion of the stroma by the endometrioid cells. A fifty-year-old woman was admitted with one month history of abdominal enlargement. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed under the clinical diagnosis of ovarian malignancy. Grossly, the righy ovary had round, encapsulated, solid and whitish gray mass which measured 9 cm in the greatest dimension and showed peripheral small cysts. Microscopic examination revealed that the tumor consisted of endometria type glands set in fibrous stroma. The glands varied from tubules to cysts and the lining cells showed complicated architectural pattern with occasional papillary infoldings, atypical mitosis and malignant nuclear characteristics. Some cysts of glands showed intraluminal mucin products. Stromal invasions by individual epithelial cells showing malignant characteristics were often found. A brief summary of the histopathologic aspect of this tumor is presented together with review of literatures.