ABSTRACT
A randomized double blind clinical trial was carried out at Siriraj Hospital in order to compare pain level during postpartum tubal sterilization between patient premedicated with intramuscular morphine and sublingual buprenorphine. Eighty postpartum women were randomly assigned to one of the two studied groups. The first group was premedicated with intramuscular morphine and oral placebo, the other received sublingual buprenorphine and intramuscular tetanus toxoid. Recorded pain level in abdominal cavity at 5 minutes before drug administration, 30 minutes after drug administration and immediately after surgery. AII side effects were observed, recorded and compared between two groups. There were no significant differences between two groups in the pain relief in postpartum tubal sterilization. Major side effects are nuasea, vomiting and dizziness. Sublingual buprenorphine can be used as a premedication in a normal postpartum women who plan to receive postpartum tubal sterilization instead of intramuscular morphine.