Sublingual Vitamin D3 Drug Therapy In Vitamin D Deficiency Patients At Pravara Rural Hospital

The present study was aimed to study the effect of Sublingual Vitamin D3on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after treatment of sublingual vitamin D3. There was statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3sublingual route having improved role of serum 25(OH)D levels in treatment of Vitamin D3deficiency patients

Evaluation of Effectiveness of Buprenorphine for Post-operative Analgesia in Terms of Duration, Quality and Side Effects by Different Routes of Administration.

Background: Buprenorphine a relatively new, potent, opioid analgesic used for post-operative analgesia and appears to be a longer lasting and has minimal side effects. Methods: Randomized comparative prospective study of 75 patients of American society of anesthesiologist physical Status grade I and II, aged between 25 and 45 years, of both sexes and requiring general anesthesia particularly for upper abdominal surgery, received buprenorphine by different routes. After surgery, when patients had Aldrete recovery score around 9-10 patients received buprenorphine 300 mcg by various routes of administration as follow: Epidural, intramuscular, intravenous slow bolus over 10 min, continuous infusion over 12 h and sublingual tablets. Patients were studied for 48 h postoperatively. The observation was made half an hourly for 2 h and then hourly. Data collected, tables formulated as per meaning full duration of action observed and as per need of simplicity for analysis. Respiration, pulse rates and blood pressure were monitored. Assessment of pain was carried out with numeric rating scale. Results: Meaning full duration of analgesia by different routes were as follows, epidural: 30-35 h in 53.33% of group population, intramuscular: 6-8 h in 86.67% of group population, intravenous bolus: 5-6 h in 73.33% of group population, intravenous infusion: 16-20 h in 60% of group population and sublingual: 5-6 h in 66.66% of group population. Side effects observed due to buprenorphine considering whole population as study sample were urinary retension in three patients (4%), Nausea in fi ve patients (6.67%), vomiting in two patients (2.66%). No cardiorespiratory depression was observed in any of the patient and route of administration technique. Conclusion: Buprenorphine produces a longer duration of meaning full analgesia by all techniques and where the epidural route is best.