ABSTRACT
Objective To evaluate the therapeutic effect of recombinant human granulocyte-macrophage colony stimulating factor ( rhGM-CSF) combined with sulfadiazine silver ( SD-Ag) unguent on deep second degree burn. Methods Eighty-nine patients with deep second-degree burn (burns areas<10%) were enrolled.These patients were divided into two groups at random (Group A and Group B).The patients in Group A were treated with SD-Ag unguent only, and those in Group B were treated with rhGM-CSF and SD-Ag unguent.The therapeutic effects and the adverse drug reaction were recorded. Results The healing time in Group A [(19.79±1.47) days] was obviously shorter than that in Group B [(15.76±1.63) days].The total wound healing rates in Group B [on day 9:(76.41±3.24)%, day 13:(95.01±1.43)%, day 16:(99.54±0.88)%, and day 21 (100.00±0.00)%] were higher than those of Group A [on day 9: (67.24±2.33)%, day 13: (75.54±1.11)%, day 16:(88.33±1.32)%, day 21:(99.14±1.95)%].During the treatment, there was no obvious adverse reaction was observed in the two groups. Conclusion The application of rhGM-CSF combined with SD-Ag unguent can not only accelerate the healing rates of deep second-degree burn, but also has curative effect with safety.
ABSTRACT
Taking example of treatment to 2 cases of large deep burn, it analyses the experience of treating large deep burn from 4 points: reasonable choice of wound dealing, preventing wound infection by correctly replacing drugs, clinical application of SD-Ag paste, and synthetic judgment of wound infection.
ABSTRACT
AIM:To prepare the sulfadiazine silver collagen sheeting for burn(SD-Ag sheeting) and determine the release rate of sulfadiazine silver METHODS:To prepare the SD-Ag sheeting by cross-linking method and to determine the release rate by uniform design RESULTS:The release rate of SD-Ag from SD-Ag sheeting was (22 38?0 036)% CONCLUSION:The preparation of SD-Ag sheeting by cross-linking method was convenient The determining method was accurate,rapid and simple for the quality control of the SD-Ag sheeting
ABSTRACT
OBJECTIVE:To prepare sulfadiazine silver film and establish a way for its quality control.METHODS:Polyvinyl alcohol was used as the main excipients for the preparation of film;the dead-stop titration was used to determine the content of sulfadiazine silver;the stability of the film sample was observed.RESULTS:The content of sulfadiazine silver was 98.9%～100.7%,the average recovery rate was 100.6%,RSD=0.69%(n=6).CONCLUSION:The prepared sulfadiazine silver film is stable in quality,accurate in content,simple in preparation and the testing method is fast.