ABSTRACT
Objective To explore the clinical effect of sustained low-efficient dialysis (SLED) combined with hemoperfusion(HP)in sepsis patients,and its protection for the kidney.Methods Sixty two patients of sepsis with acute kidney injury(AKI) were randomly divided into two groups.Based on routine treatment,control group (n =31) was treated with HP alone for 2h per day,and combined group (n =31) was treated with HP and SLED at the first 2h,and SLED for the next 10-12h.All the patients were treated for 3 days.The inflammation factors and index of renal function were detected before and after treatment,and change of haemodynamics were observed and analyzed.Results After treatment for 12,24,48h,the TNF-α,IL-6,IL-10 and Scr,BNP in both groups were all improved,while the inflammation factors in combined groups at 48h after treatment were significantly lower than those in control group,and levels of Scr and BNP at 12,24,48h after treatment were all lower than those in control group (P ＜ 0.05).There were no significant differences on the levels of CVP,MAP at 12,24,48h after treatment in combined groups (P ＞ 0.05),while these indicators were all higher than those in control group (P ＜ 0.05).Conclusion HP combined with SLED in treating sepsis with AKI can effectively remove inflammatory mediators,promote kidney function recovery and stability of hemodynamic.