ABSTRACT
Objective: To study the chemical components from Mongolian medicinal materials Ramulus syringae (the peeled roots and branches of Syringa pinnatifolia). Methods: The compounds were purified by column chromatography on silica gel, ODS, and Sephadex LH-20. Their structures were elucidated on the basis of spectroscopic methods. Results: Twenty-one compounds were isolated from R. syringae and their structures were identified as O-ethylcubebin (1), pinnatifone B (2), 3β-O-acetyl-11α,12α- epoxy-oleanan-28,13β-olide (3), coniferyl aldehydel (4), (8R,8’R,9S)-cubebin (5), isovanillic acid (6), (+)-dihydrocubebin (7), 6,10- eposoy-4α-hydroxy guaiane (8), (+)-1β,4β,6α-trihydroxyl-eudesmane (mucrolidin, 9), acutissimalignan B (10), 2-piperonylidene-3- piperonyl-1,4-butanediol (11), 4,4’-dihydroxy-3,3’,9’-triMethoxy-9,9’-epoxylignan (12), 2β-hydroxy-α-cadinol (13), cadinane-4β,5α, 10α-triol (14), larixnaphthanoe (15), lariciresinol (16), 4,4’9-trihydroxy-3,3’-dimethoxy-9,9’-epoxylignan (17), (-)-secoisolariciresino- 9,9’-acetonide (18), berchemol (19), daucosterol (20), and ecoisolariciresinol (21). Conclusion: Compounds 1, 7, 8, 9, 10, 13, 14, and 18 are isolated from the genus Syringa for the first time. Compounds 3 and 20 are isolated from S. pinnatifolia for the first time.
ABSTRACT
Objective: To study the chemical constituents from the peeled dried roots and stems of Syringa pinnatifolia. Methods: The chemical constituents from the peeled dried roots and stems of S. pinnatifolia were isolated and purified by silica gel and Sephadex LH-20 column chromatography, and preparative HPLC. The structures were identified by spectral methods. Results: Three compounds were obtained and identified as lignan, namely 3, 3', 4-trimethoxy-4', 8, 9, 9'-tetrahydroxy simple lignan (1), 3, 3', 4, 9-tetramethoxy-4', 8-dihydroxy-9'-ethoxy simple lignan (2), and 3, 3', 4, 9-tetramethoxy-4', 8, 9'-trihydroxy simple lignan (3). Conclusion: Compounds 1-3 are new, named syripinnalignan C, syripinnalignan D, and syripinnalignan E.
ABSTRACT
Objective: To investigate the chemical constituents from the stems of Syringa pinnatifolia. Methods: The chemical constituents were isolated and identified by chromatography on silica gel, ODS, and Sephadex LH-20 columns, as well as RP-HPLC. Their structures were elucidated on the basis of physicochemical properties and spectral analyses. Results: Eleven compounds were isolated from S. pinnatifolia and their structures were identified as secoisolariciresinol (1), (8R, 8'R, 9R)-4, 4'-dihydroxy-3, 3', 9-trimethoxy-9, 9'-epoxylignan (2), (8R, 8'R, 9S)-4, 4'-dihydroxy-3, 3', 9-trimethoxy-9, 9'-epoxylignan (3), (-)-pinoresinol (4), (8R, 8'R, 9'S)-4, 4'-dihydroxy-3, 3', 9'-trimethoxy-9, 9'-epoxylignan (5), (8R, 8'R, 9'R)-4, 4'-dihydroxy-3, 3', 9'-trimethoxy-9, 9'-epoxylignan (6), (9S)-9-O-methylcubebin (7), dibutylphthalate (8), piperphilippinin VI (9), balanophonin (10), and larixnaphthaone (11). Conclusion: Compounds 2-11 are isolated from the plant for the first time.