ABSTRACT
Objective To study the change of coagulation function in the patients of systemic inflammatory response syndrome (SIRS) , and to provide evidences on anticoagulation therapy. Methods All of the patients in ICU were divided into two groups: SIRS (30 patients) and non-SIRS(25 patients). Thirty healthy adults were recruited as controls. Prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT) , fibrinogen(FIB),levels of platelet (PLT) and D-dimer were measured in all patients and healthy adults. Results The levels of PT, APTT,TT.DD in the SIRS group((16.48 ± 1. 57) s, (22. 67 ± 1. 48) s, (43. 56 ±4.33)s and (2.25 ±0.18)mg/L respectively) were significantly higher than those in the non-SIRS group((12. 83 ± 1.23)s, (17. 05 ±1. 97)s,(33. 34 ±2. 38)s and(0. 58 ±0. 15)mg/L respectively)and the control group ((12. 04 ±0. 98) s,(16. 88 ±1. 37)s,(29. 84 ±1.98)s and (0.43 ±0. 11)mg/L respectively) (P <0. 05). The levels of PLT,FIB in the SIRS group((110. 69 ±50. 23) × 109/L and(2. 05 ±0. 33) g/L, respectively) were significantly lower than those in the non-SIRS group((180. 58 ±45. 70) × 109/L and(3. 54 ±0. 29)g/L,respectively)and the control group ((204. 95 ± 46. 83) × 109/L and (3. 78 ± 0. 54) g/L, respectively) (P < 0. 05). Conclusions The dysfunction of coagulation exits in SIRS. Coagulation system abnormity might play an important role in the development of SIRS.
ABSTRACT
Introducción. Los marcadores de inflamación sistémica están catalogados como asociados al tumor. Objetivos: conocer y estimar el grado de asociación entre el índice de masa corporal (IMC) y marcadores de inflamación sistémica de bajo grado en niños con cáncer. Métodos. Mediante una serie de casos se realizó la revisión de expedientes y mediciones corporales. Se consideraron variables antropométricas y bioquímicas de inflamación sistémica. El análisis de datos fue con estadística no paramétrica. Resultados. Participaron 25 pacientes. No se encontró asociación entre IMC y marcadores de inflamación sistémica de bajo grado. La prevalencia global del síndrome inflamatorio fue de 72%. El fibrinógeno mostró correlación moderada con la proteína C reactiva (r =0.500) en neoplasias sólidas y hematológicas (r =0.621), y con la VSG en estas últimas (r =0.605). Conclusiones. No existe asociación entre los marcadores de inflamación sistémica y el IMC en el grupo. La prevalencia del síndrome inflamatorio es muy alta.
Introduction. Systemic inflammation markers and cancer have been associated over the last years. Objectives: To estimate and to know the degree of association between body mass index (BMI) and markers of low-grade systemic inflammation in children with cancer. Methods. Medical histories were reviewed, and body measurements were made in a series of cases. Anthropometric variables and biochemical markers of systemic inflammation were analyzed. Non-parametric statistics was applied to data. Results. Twenty-five patients participated. No association between BMI and markers of low-grade systemic inflammation was found. Global prevalence of the inflammatory syndrome was 72%. Fibrinogen showed moderate correlation with C reactive protein (r =0.500) in both, solid and hematologic neoplasms (r =0.621), and with VSG only in the hematologic ones (r =0.605). Conclusions. No association between markers of systemic inflammation and BMI was found in this study. The prevalence of the inflammatory syndrome is very high.