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Objective To explore the TCM pathogenesis based on the analyses of TCM pattern elements. Methods TCM pattern elements of 84 patients with middle-late pancreatic cancer to analyze the TCM disease location and characteristics by their frequency and the contribution scores. Results A total of 84 patients were included, TCM disease location with the top 10 rank of the contribution scores were spleen, stomach, liver, gallbladder, kidney, intestine, lung, heart, spleen, stomach, while they were significantly higher than others (P<0.05). And the TCM pattern elements with the top 5 rank of the contribution scores were qi deficiency, dampness, heat, blood stasis, toxin, while they were significantly higher than others (P<0.01). Conclusions TCM disease locations of middle-late pancreatic cancer were mainly in spleen and stomach, and TCM pattern element were excessive patterns with qi deficiency, deficiency patterns with dampness, heat, blood stasis and toxin.
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As one of exploratory data analysis method, the clustering analysis can provide technical support for objectivity and standardization ofTCM. This paper dealt with the application of the clustering analysis in the research of Chinese medcine, TCM pattern differentiation and the regularity of TCM herbal formulae. The clustering analysis showed great value on classifying imformation and finding out regularity from data, only if the characteristics of TCM data were considered.
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Objective To study the rule with the treatment based on the pattern differentiation of systemic lupus erythematosus, by analyzing the literature of traditional Chinese medicine for the treatment of systemic lupus erythematosus from January 1999 to July 2014 included in China National Knowledge Infrastructure(CNKI) and summarizing the frequency of TCM pattern and medicine.Methods The frequency statistics and classified analysis were used to describe the patterns and medicines.Results There were 14 patterns, the common patterns are pyretic toxicity with 23(15.13%), deficiency of both qi and yin with 21(13.82%), qi and blood stasis with 20(13.16%). The disease was involved with liver, spleen and kidney. Pattern factors were mainly sthenia factors, accounting for 65.30% of the total, including hot, blood stasis, toxin, damp-heat, qi stagnation, phlegm; asthenia factors were accounted for 34.70% of the total, including deficiency of yin, deficiency of qi, deficiency of yang and deficiency of blood. There were 201 medicines included, the total frequency was 1 669, which could be into 17 categories. The top three were heat-clearing, tonic and stasis-dissolving medicines. Medicine tropisms are mainly lung tropism, stomach tropism, liver tropism, heart tropism, spleen tropism and kidney tropism, accounting for 88.12% of the total.Conclusions Pyretic toxicity is responsible for the sthenia factors of systemic lupus erythematosus, and deficiency of qi and yin is the main responsibility for asthenia factors, treatment should pay attention to both sthenia and asthenia factors.
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Objective:To observe the relationship between coronary heart disease(CHD)patterns and coronary lesion,and between the syndrome of spleen deficience with/or phlegm turbidity(SP)and coronary lesion.Methods:Traditional Chinese medicine(TCM)patterns and syndromes of 81 patients with CHD confirmed by coronary angiography(CAG)were differentiated.And the relationship between CHD patterns and coronary lesion,and between SP syndrome and coronary lesion were analyzed.The extent of coronary lesion was reflected by the affected branches and degree of arterial constriction based on CAG.Results:In 81 cases,the average affected branches amount in the group of blood stasis pattern was the most;arterial constriction degree in the group of cold-accumulation pattern was the most severe;the coronary lesion of cases in the qi-stagnation pattern group and yin-deficiency pattern group were slighter;but there was not significant difference among the CHD patterns groups.In 81 cases,there was significant difference between the SP syndrome group(38 cases)and the non-SP syndrome group(43 cases)in both affected branch distribution and arterial constriction degree.It manifested that the left circumflex artery(LCX)and right coronary artery(RCA)was easier to be affected and their constriction was more severe in the SP syndrome group.Conclusion:There was relationship between different CHD patterns and coronary lesion;coronary lesion and the clinical symptom of SP syndrome may exist the relationship of cause and effect.