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Objective To dig the correlation between genes and four TCM constitutions (phlegm-dampness, blood stasis, allergy, and dampness-heat); To analyze microscopic mechanism of constitution formed and constitution-disease correlation; To provide biological basis for TCM constitution classification and constitution-disease correlation theory. Methods Literature about TCM constitutions and gene expressions in CNKI and Wanfang Database were retrieved by computers from the establishment of database to 31, December 2016. Differentially expressed genes of four TCM constitutions were collected, and DAVID database was used for enrichment analysis, including gene tissue enrichment analysis, disease analysis, GO analysis, and pathway analysis. The results of DAVID database analysis were downloaded and analyzed. Results Four TCM constitutions had differences in gene level, and each constitution had the specificity in significantly enriched gene function, activity, pathways, related diseases, and expression locations. Different patterns of gene expression led to the constitution differences in disease susceptibility and tendency. Conclusion The essence of TCM constitution formation is the change of gene expression patterns, and the pathological changes are also caused by the change.
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Objective To explore the differences of TCM constitutions and lifestyles among the subjects with positive tumor marker screening and those with normal tumor marker screening. Methods Totally 245 subjects with positive tumor marker screening from September 2014 to December 2017 in Weihai area were selected as the observation group and 300 subjects with normal tumor marker screening were selected as the control group. Field questionnaire was used to investigate TCM constitutions and lifestyles. Results In the observation group, the ratio of constitution of yin-yang harmony was significantly lower than the control group, with statistical significance (χ2=207.483, P＜0.001). The ratios of constitution of phlegm-dampness, constitution of blood stasis, constitution of qi deficiency and constitution of qi stagnation were significantly higher than the control group, with statistical significance (P＜0.05). There was statistical significance between the 2 groups in irregular rest, heavy drinking, regular smoking, lack of exercise, irregular diet and partial eclipse (P＜0.05). CEA, a positive indicator of tumor markers in the observation group, was commonly found in constitution of phlegm-dampness (40.43％) and constitution of qi deficiency (22.70％); CA199 was commonly found in constitution of qi stagnation (38.71％) and constitution of qi deficiency (24.19％); AFP was commonly found in constitution of blood stasis (38.46％) and constitution of qi deficiency (23.08％); CA125 was commonly found in constitution of blood stasis (33.33％) and constitution of qi stagnation (19.05％); CYFRA21-1 was commonly found in constitution of phlegm-dampness (54.55％) and constitution of qi deficiency (22.73％); PSA was commonly found in constitution of phlegm-dampness (61.52％) and constitution of damp-heat (23.08％). Conclusion Effectively controling the distribution of TCM constitutions of subjects with positive tumor marker screening in Weihai area and understanding the influence of lifestyles on tumor markers can provide guidance for clinical improvement of patients' biased constitutions and reduction of positive indicators of tumor markers.
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Objective To study the correlation between TCM constitutions and sleep quality in the elderly population in Hunan Province; To provide a basis for improving sleep quality and adjusting the unbalanced constitutions of the elderly. Methods Multi-stage stratified sampling combined with convenient sampling method was used. TCM constitution rating scale, Pittsburgh sleep quality index, and self-designed general demographic, health and lifestyle questionnaire were used to conduct cross-sectional survey of elderly people living in Hunan Province. Results PSQI scores were negatively correlated with the balanced constitution, and positively correlated with unbalanced constitution, and sleep disturbance was closely related to yang deficiency and qi deficiency. The damp heat, phlegm-dampness, blood stasis, yin deficiency and qi deficiency got the highest scores in the five factors of sleep latency, sleep duration, sleep efficiency, sleep disorders and daytime dysfunction respectively. Conclusion Sleep problems of the elderly in Hunan Province are more prominent, and constitutions and sleep quality affect each other. Different TCM constitutions of sleep disorders in the elderly are different, and should be adjusted according to the constitutions.
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Triple negative breast cancer (TNBC) is a special subtype of breast cancer which lacks expression of the estrogen receptor, progesterone receptor and HER-2. The treatment of TNBC remains a challenge, due to its high heterogeneity, aggressive pattern and insensitivity to endocrine, so the HER-2-directed therapy is ineffective and prognosis is poor. TCM treatment has certain advantages in treating TNBC. The complementation of traditional Chinese and Western medicine should be paid attention to in the process of syndrome differentiation. Differential diagnosis of disease in Western medicine should correspond to treatment based on syndrome differentiation and the concept of wholism in TCM. For different stages of the disease, it is also important to emphasize the relations between supporting the healthy energy and eliminating the evil factors, and the whole and the part before the prescription to analyze and grasp of TCM constitution, to exert the superiority of TCM in treating TNBC.
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Objective To analyze scientific projects about TCM constitutions funded by National Natural Science Foundation (NSFC); To understand its development trend and current situation.Methods The scientific projects about TCM constitutions in the fields of H27 and H29 were retrieved in NSFC Network Information System during 1996-2016 and "Dingxiangtong" during 1985-2015. Project year, branch discipline, project category, relying-on units were analyzed. PICO model of evidence-based medicine to build clinical problems was applied to analyze project research objects, clinical or scientific issues, interventions, methods, effects indicators, and the role of links. Results There were totally 61 scientific projects and 26.38 millions yuan funded by NSFC in TCM constitutions during 1988-2016. Project and the amount of fund to overall were on the rise, especially since 2010. There were 48 projects about TCM science, 21.77 million yuan (82.5％), 13 projects about integrated traditional Chinese and Western medicine, 4.61 million yuan (17.5％), including 27 surface projects, 11.32 million yuan (42.9％), 17 youth science fund, 3.32 million yuan (12.6％), 15 regional science fund projects, 6.34 million yuan (24.0％), and 2 key projects, 5.4 million yuan (20.5％). The units with the most foundation were Beijing University of Chinese Medicine (15), Xinjiang Medical University (6), Shanghai University of Traditional Chinese Medicine (5). TCM constitution of zang-fu, qi and blood, and body fluid, clinical basis of integrated traditional Chinese and Western medicine, and basic principles of integrated traditional Chinese and Western medicine were the branches with the most foundation. Conclusion s Supported by NSFC, marked improvement and progress have been achieved in research on TCM constitutions.
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Objective To analyze the improved the effects of prevention and treatment by integrated tradition Chinese and Western medicine on TCM constitutions and relevant indexes of community diabetic patients; To provide a reference for the comprehensive prevention and treatment of community diabetes.Methods By using cluster sampling method, 700 patients with diabetes aged 45 to 65 in healthcare service center in Minhang District in Shanghai were chosen randomly and divided into intervention group and control group, with 350 cases in each group. The control group used information platform, and was treated with standardized management and treatment of diabetes. On the basis of the treatment of the control group, the intervention group was identified TCM constitutions once a month, developed personalized community diabetes prevention and treatment of TCM norms, and gave guidance and intervention for health preserving and disease prevention for a year. The TCM constitution improvement was observed. Diabetic symptoms grading scale and anxiety self-rating scale, depression self-rating scale were assessed, and the complications were observed.Results Before intervention: TCM constitution of yin-yang harmony (51.43％) > yin asthenia (18.29％) > qi asthenia (11.71％) > yang asthenia (9.71％) > damp-heat (1.57％). After intervention: TCM constitution of yin-yang harmony (63.71％) > yin asthenia (8.71％) > qi asthenia (6.57％), yang asthenia (6.29％) > damp-heat (1.71％). There was difference in constitutions of yin-yang harmony, yang asthenia, and damp-heat before and after and through intervention and group interaction (P<0.05). There was statistical significance in diabetes symptoms curative effect index between the two groups (P=0.021). There was statistical significance in ophthalmoscopy results before and after and through intervention and group interaction (P=0.002).Conclusion The prevention and treatment by intervention of integrated traditional Chinese and Western medicine can improve the TCM constitutions of diabetic patients in community and influence the symptoms of diabetes.
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Objective To explore the prediction efficiency of multilayer perception (MLP) model in prediction of diabetes mellitus (DM) complicated with coronary heart disease (CHD) by TCM personality and constitutions; To provide a new method for objective prediction. Methods This research utilized single factor logistic regression to filter out variables, which were significant factors of TCM personality and constitutions as analytic variables for MLP and multivariate logistic regression to establish TCM prediction model of personality and constitutions for DM complicated with CHD. The prediction efficiency of the above models were tested by receiver operating characteristic curve (ROC curve). Results The sensitivity, specificity and AUC of MLP were 0.915 (0.862, 0.968), 0.846 (0.793, 0.912) and 0.913 (0.806, 0.987) respectively, which was better than the logistic regression, while these indexes of logistic regression were 0.834 (0.695, 0.953), 0.762 (0.623, 0.901), and 0.869 (0.730, 0.941) respectively. Conclusion The MLP model is better than logistic regression model in prediction of DM complicated with CHD by TCM personality and constitutions.
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Objective To discuss the correlation between the dysmenorrhea and TCM constitutions among the junior high school girls of Shanghai suburb; To analyze the influencing factors; To provide references for the prevention of dysmenorrhea. Methods By using cluster sampling during December 2015 to January 2016, the questionnaire surveys which included the general situation, the classification and determination of TCM constitution self-test and COX Menstrual Symptom Scale were used for the junior high school girls from the suburb area of Shanghai to analyze the relationship between dysmenorrhea and TCM constitutions and the influencing factors. Results The incidence rate of dysmenorrhea was 29.52% (93/315) in junior high school girls from the suburb area of Shanghai. There was statistical significance in body height and menarche age among girls with and without dysmenorrhea (P<0.05). The rank correlation coefficient of dysmenorrhea and gentleness type was -0.130 (P=0.021). The rank correlation coefficients of dysmenorrhea and pathological constitution (except for special diathesis type) were all greater than 0 (P<0.05). Univariate analysis showed that there was statistical significance in the incidence of different coagula in menses, different inheritance of dysmenorrhea, different sleep quality, different learning pressure, different emotional state and different physical exercises (P<0.05). Logistic regression analysis showed that influence factors of dysmenorrhea were inheritance of dysmenorrhea, learning pressure and yin-deficiency constitution. Conclusion The pathological constitution is the susceptible constitution of dysmenorrhea of junior high school girls. Yin-deficiency constitution, inheritance of dysmenorrhea and learning pressure can increase the incidence of dysmenorrhea. It is suggested that the corresponding preventive measures should be taken to achieve the purpose of prevention dysmenorrhea by regulating and improving yin-deficiency constitution.
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Objective To study the correlation between nontraumatic osteonecrosis of femoral head (NONFH) and ApoA1 polymorphism of blood stasis type.Methods Totally 93 cases of NONFH were selected as the case group, and 83 healthy volunteers were randomly selected as the control group. With TCM constitution questionnaire survey, the case group was screened out 32 cases of blood stasis NONFH type and 61 cases of non blood stasis NONFH type. In the case group and control group, the subjects took blood samples 2 mL, extracted DNA for PCR amplification, PCR products for DNA sequencing. G994T PAF-AH and rs9658282 gene NOS1 site polymorphism were detected for tatistical analysis.Results -75G/A gene AA ApoA1 genotype (OR: 2.578; 95%CI: 1.174-5.663;P=0.018) and A allele (OR: 1.726; 95%CI: 1.121-2.658;P=0.013) may be one of the risk factors of NONFH.Conclusion -75G/A gene ApoA1 may be related to the pathogenesis of NONFH. There was no correlation between the ApoA1 gene polymorphism of -75G/A gene and the pathogenesis of blood stasis NONFH. There was no correlation between the ApoA1 gene polymorphism of +83C/T gene and the pathogenesis of blood stasis NONFH.
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Objective To explore the relationship between quality life and TCM constitutions of elderly patients with hypertension in a community in Shanghai; To provide the basis for the suitable and feasible community elderly hypertension management method. Methods Through multistage stratified sampling method, 808 elderly patients with hypertension in the community were investigated for their life quality and TCM constitutions on the basis of inform consent and voluntary participation. The life quality and TCM constitution characteristics as well as the relationship were analyzed by applying the statistic analysis software. Results Among the investigated elderly patients with hypertension in the community, 97.28% cases’ overall life quality was above the middle level and 91.46% cases’ self-evaluated health and quality of life scores were above the middle level. 54.70% cases were gentleness type, and the biased constitution was dominated by qi deficiency, yang asthenia, yin asthenia and phlegmatic hygrosis. The relationship between life quality and TCM constitutions may be existent. If TCM constitutions tended to be gentleness type, the physical score and the psychological score would be higher, which leaded to better quality of life. Conclusion TCM constitution characteristics are associated with quality life of elderly hypertension patients in the community. Intervention targeted on the results of TCM constitution identification would be better to prevent and control hypertension and improve health level and quality of life.
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Objective To study the distribution characteristics of TCM constitutions of hormone-dependent breast cancer patients; To provide references for TCM diagnosis and treatment.Methods TCM constitution differentiation in the 210 patients with hormone-dependent breast cancer were investigated by a questionnaire survey, which is made according to the Classification and Determination of TCM Constitutions invented by professor Wang Qi and four methods of diagnosis of TCM, with a purpose to investigate the correlation of TCM constitutions and TCM syndrome differentiation typing.Results There was statistical significance among TCM constitutions of the 210 patients with hormone-dependent breast cancer (P<0.001), with yin deficiency 43.8% (92 cases), qi stagnation 15.2% (32 cases), qi deficiency 11.4% (24 cases), blood stasis 7.6% (16 cases), and yang deficiency 6.7% (14 cases). There was statistical significance among TCM syndromes (P<0.001), with dysfunction of Chong and Ren channels 63.8% (134 cases), stagnation of liver qi syndrome 16.2% (34 cases), weakness of the spleen and stomach syndrome 11.4% (24 cases). There was statistical significance between dysfunction of Chong and Ren channels and correlation of TCM constitutions (P<0.001).Conclusion Most hormone-dependent breast cancer patients are accompanied with yin deficiency pattern and the syndrome differentiation typing of dysfunction of Chong and Ren channels. There is correlation between dysfunction of Chong and Ren channels and TCM constitutions.
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Objective To compare the differences between TCM constitution test and fitness test of university students from different aspects;To prove that bringing TCM constitution test into fitness test of university students is feasible. Methods Comparative method was used to compare the differences between TCM constitution test and fitness test of university students from the aspects of basic theory, test content, test methods, and interventions. Results There were differences on the aspects of basic theory, test content, test methods, and interventions between TCM constitution teat and fitness test of university students. The test population and test aim were the same. TCM constitution test could comprehensively test physical, psychological, and social adaptability of university students. The individualized program of health maintenance could be given according to TCM constitutions after TCM constitution test. But this test is subjective. The fitness test of university students mainly focus on measuring physical health and the test method is objective. Conclusion TCM constitution test can be brought into current fitness test of university students to test their healthy condition more comprehensively and accurately. The individualized program of health maintenance can be offered after the test to promote health of university students.