ABSTRACT
Total glucosides of paeony root ( TGPs ) ( 5 ~40mg/kg, ip ) had a dose-related hypothermal effect in mice and rats, which was related to the environment temperature. But TGPs ( 40mg/kg, ip or iv ) showed no significant hypothermal effect in guinea-pigs or rabbits. TGPs ( 2, 4 mg/kg, icv ) had a potential hypothermal effect in rats. Chlopheniramine had antagonist effect on hypothermal effect of TGPs in mice and rats.
ABSTRACT
Total Glucosides of Paeony Root ( TGPs, 5-40 mg/kg) had a dose-related increasing effect on the survival time of mice under normobaric hypoxia. TGPs (20 mg/kg) had a significant increasing effect on survival time of mice under hypobaric hypoxia & a decreasing effect in the oxygen consumption in mice. TGPs ( 40mg/kg ) decreased the mortality of mice from the acute hypoxia induced by KCN. Increasing effect on the survival time of mice under normobaric hypoxia of TGPs was significantly antagonised by chlortrimeton. The efficacy of TGPs (icv 2.5-5 mg/kg) approximated to that of TGPs (ip 5-40 mg/kg) respectively. It suggested that the effect of TGPs on resistance to hypoxia was produced by central nervous system. The efficacy of TGPs ( icv) was significantly antagonised by chlortrimeton. It was shown that the effect of TGPs was produced by H1-receptor. In the experiment of resistance to hypoxia of TGPs (ip or icv), we measured the change of rectal temperature of mice. The data indicated the positive corr- elation of both effects of TGPs (r=0.58, P
ABSTRACT
The protective effect of TGPs on acute liver damage induced by carbon tetrachloride ( CCl4 ) was investigated in mice . TGPs ( 40 or 80mg/kg?d ? 3d, ip ) reduced the elevation of plasma or serume gl- utamic pyruvic transaminase ( GPT ) and plasma lactate dehydroge-nase ( LDH ) in CCl4-intoxicated mice, but if had no significant influence on the elevation of plasma glutamic oxalacetic transaminase ( GOT).TGPs (40mg/kg?d ? 3d, ip ) showed a protective effect on the histopathologic changes of liver injury induced by CCl4. The results suggest that TGPs may a protect against hepatic damage.