1.
Journal of Medical Research
;
(12)2006.
Article
in Chinese
| WPRIM
| ID: wpr-567575
ABSTRACT
Objective To study the effect of Toll-like receptor 4(TLR4)on expression of IRF-3 and IFN-? during the inflammatory reaction induced by cerebral ischemia reperfusion in mice. Methods After blockade of TLR4 by TLR4 antibody,expression of TLR4,IRF-3 and IFN-? at the protein level in hippocampus was examined by Western blot,respectively. Mice were randomly divided into sham group,ischemia reperfusion group and TLR4 blocking group in different time points (1,2,3 and 4 day). Results In the right cortex,the expression of TLR4,IRF-3 and IFN-? of I group was distinctly higher than that of S and T group(P