ABSTRACT
OBJECTIVE: To investigate the pregnancy outcome and pregnancy complications in patients with subclinical hypothyroidism with negative anti-thyroid peroxidase(TPO-Ab)in early pregnancy.METHODS:From January 2016 to February 2018,4,616 cases of early-gestation pregnant women in Shanghai Tinglin Hospital were selected.According to the age,the patients were divided into groups of 18-24 years old(602 cases),25-29 years old(2604 cases),30-34 years old(1330 cases),and over 35 years old(80 cases).Subclinical incidence of TPO-Ab-negative hypothyroidism in pregnant women of different age groups was compared.According to whether TPO-Ab-negative subclinical hypothyroidism patients received LT4 replacement therapy, they were divided into treatment group(receiving treatment,160 cases)and observation group(not receiving treatment,98 cases),and 526 normal pregnant women in the same period were included as the control group.The incidence of various pregnancy complications and pregnancy outcomes and their statistical significance were compared among the three groups.RESULTS:Comparison of the incidence of TPO-Abnegative subclinical hypothyroidism:the age group of 30-34 years old(7.97%)was higher than the age group of 25-29 years old(5.99%)and the age group of 18-24 years old(3.99%);the age group of over 35 years old(12.50%)was higher than the age group of 25-29(5.99%)and the age group of 18-24(3.99%);the age of over 35 years old(12.50%)was higher than the age group of 25-29(5.99%)and the age group of 18-24(3.99%),and the differences were statistically significant(P<0.05).The incidence of gestational diabetes was higher in the observation group(14.29%)than in the treatment group(6.25%)and the control group(4.94%),and the incidence of anemia in the observation group(44.90%)was higher than that in the treatment group(30.00%)and the normal control group(26.04%).The neonatal birth weight of the treatment group(3200±300 g)and the control group(3150±statistical significance(P<0.05).CONCLUSION:The incidence of TPO-Ab-negative subclinical hypothyroidism in early pregnancy increases with age.Timely intervention should be given to reduce the occurrence of gestational anemia diabetes,which is conducive to the growth and development of offsprings.