ABSTRACT
With the development and utilization of nuclear energy, the safe operation of nuclear facilities has become a social issue of great concern. China attaches great importance to nuclear emergency plan and the construction of legal, institutional, and mechanism systems. Among them, the emergency preparedness and response of airborne monitoring for nuclear emergency is one of the important components of the national nuclear emergency system. The technology system of airborne monitoring for nuclear emergency is being developed and combines the advantages of manned aircraft and unmanned aerial vehicle (UAV) airborne monitoring. In recent years, UAVs with different loads and types have been developed, with diversified sizes and types of detectors carried by UAVs. The research on UAV airborne monitoring techniques for nuclear emergency has been continuously deepened and improved, and the technical system of airborne monitoring for nuclear emergency has been developed at the same time. The construction of UAV airborne monitoring technology system for nuclear emergency is discussed from the perspectives of monitoring equipment and technology, emergency response plan, emergency monitoring and evaluation, monitoring standards, emergency personnel, emergency support, and training and exercise. The UAV is a rapidly developing aircraft. With the continuous improvement in UAV performance and the continuous innovation and development of nuclear emergency airborne monitoring technology, the UAV airborne monitoring technology system for nuclear emergency will be constantly improved and developed towards networking, intelligence, and standardization.
ABSTRACT
“Green manufacturing” is a modern manufacturing model that comprehensively considers environmental impact and resource consumption. Its purpose is to minimize the negative impact on the environment and maximize resource utilization, and to coordinate and optimize the economic and social benefits of the enterprise. The Outline for Strategic Development of Chinese Medicine (2016—2030) clearly defines to establish a green manufacturing system for Chinese materia medica (CMM) as a key task, and it is imminent to vigorously promote “green manufacturing” concepts and technologies in the pharmaceutical industry of CMM. Based on the basic concept of “green manufacturing” and the scientific practice of the author’s research group for many years, this article systematically discusses the concept, goals and key research content of green manufacturing of CMM in order to provide reference for the construction of “the theory and technology system of green manufacturing of traditional Chinese medicine”. The main arguments include that green manufacturing of CMM is a systematic project, the positioning of resources in the theory and technology system of green manufacturing of CMM has a national strategic significance; A chemical combination with various active ingredients is the core value of CMM resources; Separation is the core of green manufacturing process technology, and industrial ecology with its practical product “industrial ecological park” is the fundamental way out of green manufacturing of CMM.
ABSTRACT
Thanks to the improving new drug approval system and the wide application of new technology in China,the development of traditional Chinese medicine (TCM) meets the golden opportunity at the best conditions.In the further research of new drugs,effective data mining of ancient literatures and clinical medication experience need paying more attention supported by research data of clinical efficacy of new Chinese drugs,as it is generally recognized,for the establishment of the approval system of syndrome types.In addition,we should prudently value the safety issues on TCM and improve the classification and registration of new Chinese drugs and drug approval in the future.Therefore,the research and development of modern drugs,evaluation standard and review experience of new Chinese drugs in the recent three decades need integrating for the establishment of the improvement of the technology system of drug review and registration in conformity with the characteristics of TCM of great significance in the clinical service and industrial development of TCM.
ABSTRACT
In order to ensure the safety and effectiveness of biotech drugs, the CFDA has released a series of regulations and guidelines, and the NIFDC established an effective quality control technology system for recombinant drugs. This paper briefly reviews the important development stage of pharmaceutical biotechnology and the research and development situation of recombinant drugs in China, introduces in detail the establishment and application situation of the quality control technology system for recombinant drugs in the last 30 years in China, including the research basis and regulatory requirements for the quality standard, the quality standards of recombinant drugs in Chinese Pharmacopoeia Part III and the quality control requirements for recombinant drugs in the current Pharmacopoeia, the support of national science and technology projects for establishing quality control system of biotechnology drugs by NIFDC and the establishment and application of the recombinant drug quality standards and all kinds of test methods such as the determination of biological activity and protein content, physical and chemical analysis and protein structural identification, determination of purity and impurity since 1986; development of national standards for biological activity and content determination, establishment and validation of the quality standards of the physical and chemical reference substances used for peptide mapping analysis and isoelectric point determination of recombinant drugs; analysis of inspection reports of a total of 5 920 batches of biotech drugs for all kinds of tests including registration inspection, import inspection, sample inspection, commission, and contracts tests completed by Division of Recombinant Biological Products, IBPC, and NIFDC since 2001.