ABSTRACT
Objective To analyze the clinical efficacy and toxic reaction of Tegafur,Gimeraciland Oteracil Potassium Capsule combined with Gemcitabine chemotherapy for patients with radical resection for advanced gallbladder carcinoma.Methods The clinical dataof 135 patients with advanced gallbladder cancer who were admitted to the 1 st Affiliated Hospital of Zhengzhou University and supported after the gastrectomy by the pathology from June 2007 to June 2012 were retrospectively analyzed.All patients were divided into three groups by different therapeutic regimens,operation groups (Radical resection or Extended radical resection of gallbladder carcinoma) with 47 cases,chemotherapy A group (Tegafur,Gimeracil and Oteracil Potassium Capsule combined with Gemcitabine chemotherapy after Radical resection or Extended radical resection of gallbladder carcinoma) with 52 cases,and chemotherapy B group (5-Fluorouracil combined with Oxaliplatin chemotherapy after Radical resection or Extended radical resection of gallbladder carcinoma) with 36 cases.We collected the dates of all patients with the median survival time and the 1,3 and 5-year survival rate after operation,and counted the rate of major toxic reaction after chemotherapy.Results There were no significant differences in the general date of three groups (sex,age,tumor size,CA19-9,CA125,TNM stages,with or without cholecystolithiasis,operation methods,operation complication),The chemotherapy A group and chemotherapy B group had no differenceswiththe median survival time and 1,3 and 5-year survival rate after operation.There were significant differences in the median survival time and 3,5-year survival rate after operation between the operation group and chemotherapy A group (or between the operation group and chemotherapy B group).There were significant differences in the rate of whole toxic reaction and the rate of toxic reaction beyond Ⅲ degree between chemotherapy A group and chemotherapy B group.Conclusions The treatment of Tegafur,Gimeracil and Oteracil Potassium Capsule combined with Gemcitabine chemotherapy for patients with radical resection of advanced gallbladder carcinoma has a lower rate of whole toxic reaction and rate of toxic reaction beyond Ⅲ degree than 5-Fluorouracil combined with Oxaliplatin chemotherapy,and for patients with advanced gallbladder carcinoma,the frontal treatment can obviously prolong the median survival time and effectively improve the 3 and 5-year survival rate after operation.
ABSTRACT
Objective: To evaluate the efficacy and toxicity of docetaxel combined with tegafur,gimeracil and oteracil potassium (S-1) capsules in the treatment of patients with advancedadenocarcinoma of esophagogastric junction (AEG). Methods: Fifty-eight patients with advanced AEGwere recruited in this study between January 2009 and January 2011. All patients were treated withchemotherapy of docetaxel (35 mg·m-2·d-1 on d 1 and d 8; intravenous injection) combined with S-1capsule (70 mg/m2 daily for 14 days). The chemotherapy cycle was repeated every 21 days. The short-termresponse and the toxicity were evaluated every two cycles and one cycle, respectively. The follow-upexaminations were performed in all patients, and the survival was calculated. Results: Of the 58 patients,there were 5 patients (8.6%) with complete response, 21 patients (36.2%) with partial response, 18patients (31.0%) with stable disease, and 14 patients (24.1%) with progressive disease. The total responserate was 44.8% (26/58). The median time to progression was 8.0 months, and the median survival timewas 10.5 months. The major toxicities included leucopenia, stomatitis, hand-foot syndrome and adversereactions of gastrointestinal tract. The rate of grade ¢ó-¢ô leucopenia was 25.9% (15/58). Conclusion: Docetaxel combined with S-1 capsule is effective and tolerable in the treatment of patients with advanced AEG. Copyright© 2011 by TUMOR.