Analysis of the trend of medication use in patients with ulcerative colitis in a single center from 2010 to 2019 / 中华消化杂志

Objective:To analyze the trend of medication use in patients with ulcerative colitis (UC) in recent ten years in at Xijing Hospital, Air Force Military Medical University.Methods:From 2010 to 2019, the clinical data of 1 425 patients diagnosed with UC in the Department of Gastroenterology at Xijing Hospital, Air Force Medical University, were retrospectively collected. According to the period of medication, the UC patients were divided into year 2010 to 2014 group and year 2015 to 2019 group. The general information and the medication trend of year 2010 to 2014 group and year 2015 to 2019 group were analyzed. And then according to gender and age (<40 years old and ≥40 years old), patients were divided into subgroups and analyzed. Independent sample t test and chi-square test were used for statistical analysis. Results:The number of UC patients of year 2010 to 2014 group and year 2015 to 2019 group was 369 and 1 056, respectively. The percentages of patients in remission of the two groups were 9.5% (35/369) and 12.0% (127/1 056), respectively; the percentages of mild patients were 40.4% (149/369) and 41.6% (439/1 056), respectively; the percentages of moderate patients were 37.4% (138/369) and 28.9% (305/1 056), respectively; the percentages of severe patients were 12.7% (47/369) and 17.5% (185/1 056), respectively. There was no significant difference in the proportion of UC patients with different degrees between year 2010 to 2014 group and year 2015 to 2019 group ( P>0.05). There were no significant differences in the age and proportion of female between the year 2010 to 2014 group and year 2015 to 2019 group ((46.2±15.3) years old vs. (44.6±30.6) years old; 45.8%, 169/369 vs. 44.8%, 473/1 056; both P>0.05). The utilization rates of 5-aminosalicylic acid (5-ASA), glucocorticoid, immunosuppressants, and biological agents of the year 2015 to 2019 group were all higher than those of the year 2010 to 2014 group (96.8%, 1 022/1 056 vs. 90.0%, 332/369; 29.9%, 316/1 056 vs. 14.6%, 54/369; 8.4%, 89/1 056 vs. 2.4%, 9/369; 4.8%, 51/1 056 vs. 0.5%, 2/369, respectively), and the differences were all statistically significant ( χ2=26.766, 33.256, 15.315 and 14.038, all P<0.01). Within each of the year 2010 to 2014 group and the year 2015 to 2019 group, there were no significant differences between the female and male in the age, utilization rates of 5-ASA, glucocorticoid, immunosuppressants and biological agents ((47.2±13.6) years old vs. (45.3±16.5) years old, (43.1±12.9) years old vs. (45.8±39.5) years old, 88.8%, 150/169 vs. 91.0%, 182/200; 96.8%, 458/473 vs. 96.7%, 564/583; 13.6%, 23/169 vs. 15.5%, 31/200; 28.3%, 134/473 vs. 31.2%, 182/583; 2.4%, 4/169 vs. 2.5%, 5/200; 7.0%, 33/473 vs. 9.6%, 56/583; 0 vs. 1.0%, 2/200; 5.3%, 25/473 vs. 4.5%, 26/583; all P>0.05). In the patients aged≥40 years old of the year 2010 to 2014 group, the proportion of females was higher than that of the patients aged <40 years old (50.2%, 121/241 vs. 37.5%, 48/128), and the utilization rate of 5-ASA in patients aged ≥40 years old was lower than that of patients aged <40 years old (85.9%, 207/241 vs. 97.7%, 125/128), and the differences were statistically significant ( χ2=5.438 and 12.824, P=0.020 and P<0.01). In the year 2010 to 2014 group, there were no statistically significant differences in the utilization rates of glucocorticoid, immunosuppressants and biological agents between patients aged ≥40 years old and patients aged <40 years old (13.7%, 33/241 vs. 16.4%, 21/128; 2.1%, 5/241 vs. 3.1%, 4/128; 0 vs. 1.6%, 2/128; all P>0.05). In the year 2015 to 2019 group, the utilization rate of biological agents in patients aged≥40 years old was lower than that in patients aged<40 years old (3.7%, 23/630 vs. 46.5%, 198/426), and the difference was statistically significant ( χ2=4.721, P=0.030). In the year 2015 to 2019 group, there were no statistically significant differences in female proportion, utilization rates of 5-ASA, glucocorticoid, immunosuppressants and biological agents between patients aged≥40 years old and patients aged <40 years old (43.7%, 275/630 vs. 46.5%, 198/426; 96.0%, 605/630 vs. 97.9%, 417/426; 29.7%, 187/630 vs. 30.3%, 129/426; 8.6%, 54/630 vs. 8.2%, 35/426; all P>0.05). Conclusions:Compared with year 2010 to 2014, the number of UC patients remarkably increased in the year 2015 to 2019 in the Department of Gastroenterology, Xijing Hospiatal, Air Force Medical University. The utilization rates of 5-ASA, glucocorticoid, immunosuppressants and biological agents all increased in UC patients. The medication trends of UC patients with different gender were almost the same. The medication trends of UC patients with different age were different.

A decade′s review for the foundation, establishment and development of the Department of Minimally Invasive Gastrointestinal Surgery in Peking University Cancer Hospital / 中华胃肠外科杂志

Department of minimally invasive gastrointestinal surgery in Peking University Cancer Hospital (also named as Department of Gastrointestinal Surgery IV) was established on April 7, 2009. Up to now, ten years have passed since its foundation. As the first department built in specialized cancer hospital, which mainly focuses on laparoscopic surgery, its foundation and development has a very important historical and practical significance in the development of surgical oncology in China. Reviewing the rapid growth of the Department of Minimally Invasive Gastrointestinal Surgery over the past decade, on the one hand, it has benefited from the opportunities of the times and the support of leaders in Peking University Cancer Hospital at that time. More importantly, the progress owes to the pioneering Professor Su Xiangqian, who is brave and innovative, with indomitable spirit and advanced management philosophy. With rigorous training, the ability of the team has been steadily enhanced, the competitiveness has been gradually improved, and the development direction which focuses on laparoscopic gastric cancer surgery and laparoscopic colorectal cancer surgery has been established. Now, the Department of Minimally Invasive Gastrointestinal Surgery has become a well-known domestic gastrointestinal tumor center. In the past ten years, under the leadership of Professor Su Xiangqian, the growth of this team is innovative and comprehensive: (1) Introduce the internationally advanced Baldrige medical service management framework, and propose the "management by principle" concept to improve the core competitiveness of the department; (2) Establish an academic brand by laparoscopic standardized surgery training courses for gastrointestinal tumors, promote cooperation and exchange at home and abroad, and participate in international multi-center clinical research projects; (3) Adhere to the "formation of a research-oriented department, conducting clinical and basic research simultaneously" as the development direction; (4) Stick to the core development concept of team building and cultivate professional talents. Looking forward to the future, our team will not forget the beginning of the heart, and move forward! In the next ten years, we will break through ourselves and continue to pursue the higher level!

Ten Years of the Korean Thyroid Association: Achievement and Future

The Korean Thyroid Association (KTA) is a multi-disciplinary organization founded by various Korean societies involved in thyroid disease. The KTA has become a foundation stone of the rapid development of the thyroidology in Korea by utilizing the characteristic of multi-discipline for the past 10 years. On February 16, 2008, the inaugural conference was held with great success. Since then, in a short period of 10 years, the number of lifetime members of the KTA reached 623. On March 29, 2012, the KTA became an approved organization by Korean Medical Association within the record time of 4 years after its establishment. In terms of patient care, mutual cooperation among experts in the various fields of thyroid disease have been promoted based on the KTA. On the academic side, the number of papers were awarded and published at international conferences or international academic journals has increased dramatically, and finally, the research on thyroid disease in Korea has reached the global level. The KTA is a multi-disciplinary society consisting of experts from various fields such as internal medicine, surgery, otolaryngology, nuclear medicine, radiology, and pathology. The reason why the KTA has achieved unparalleled growth is that all the KTA members, including senior professors who served as the president and vice president, and incumbent executives, have been harmonized and developed together. Here, we review the activities of the KTA for 10 years from its establishment, and present the future direction of the KTA.

Prevalence of overweight and obesity among children six to ten years of age in the North-East Health region of Jamaica / Prevalencia del sobrepeso y la obesidad entre niños de seis a diez años de edad en la región Noreste de atención a la salud en Jamaica

OBJECTIVE: To estimate the prevalence and correlates of overweight and obesity among children six to ten years old in the NorthEast Health Region (NEHR) of Jamaica. METHODS: Weights and heights were measured in a representative sample of 5710 children between the ages of six and ten years in 34 schools between October 2008 and March 2009. Overweight and obesity were defined as body mass index (BMI) Zscore >1SD and >2SD, respectively based on the World Health Organization (WHO)endorsed age and genderspecific growth standards for children. Point prevalence estimates of overweight and obesity were calculated. Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate associations between overweight and obesity and age, gender and school location. RESULTS: Overweight and obesity prevalence among children six to ten years old in NEHR, Jamaica, was 10.6% and 7.1%, respectively. Overweight (OR = 1.11, 95% CI: 1.04, 1.18) and obesity (OR = 1.17, 95% CI: 1.08, 1.26) prevalence increased significantly with age. Overweight (OR = 1.51, 95% CI: 1.27, 1.80) and obesity (OR = 1.36, 95% CI: 1.11, 1.67) prevalence was significantly higher among girls than boys. Children attending ruralpublic schools had less risk of being overweight (OR = 0.57, 95% CI: 0.46, 0.70) and obese (OR = 0.35, 95% CI: 0.28, 0.44) when compared with urbanpublic schools and private schools. Both overweight (OR = 2.11, 95% CI: 1.60, 2.78) and obesity (OR = 1.68, 95% CI: 1.24, 2.28) were significantly more common among children attending private schools. After adjusting for age and gender, the results still remained statistically significant. CONCLUSIONS: Overweight/obesity prevalence among children six to ten years old in NEHR of Jamaica is 17.7% with older children and girls having higher rates. Children attending urbanpublic and private schools have higher prevalence than those attending rural schools. Appropriately targeted interventions are needed to combat this problem.

OBJETIVO: Estimar la prevalencia y los correlatos de sobrepeso y obesidad entre niños de seis a diez años en la región noreste de atención a la salud (RNAS) de Jamaica. SUJETOS Y MÉTODOS: Se midió el peso y la altura en una muestra representativa de 5710 niños en edades entre seis y diez años, en 34 escuelas, entre octubre de 2008 y marzo de 2009. El sobrepeso y la obesidad se definieron como el índice de masa corporal (IMC) de puntuación Z > 1SD y > 2SD, respectivamente, tomando como base las normas específicas de crecimiento por género y edad para los niños, aprobadas por la Organización Mundial de la Salud (OMS). Se calcularon los estimados de prevalencia puntual del sobrepeso y la obesidad. Se utilizaron los cocientes de probabilidades relativas (OR) e intervalos de confianza (IC) del 95%, a fin de determinar las asociaciones entre el sobrepeso y la obesidad por un lado, y la edad, el género y lugar de la escuela, por otro lado. RESULTADOS: La prevalencia del sobrepeso y la obesidad entre los niños de seis a diez años en la RNAS, Jamaica, fue de 10.6% y 7.1%, respectivamente. La prevalencia del sobrepeso (OR = 1.11, IC de 95%: 1.04, 1.18) y de la obesidad (OR = 1.17, IC del 95%: 1.08, 1.26) aumentó significativamente con la edad. La prevalencia del sobrepeso (OR = 1.51, IC del 95%: 1.27, 1.80) y la obesidad (OR = 1,36, IC de 95%: 1.11, 1.67) fue significativamente mayor entre las hembras que entre los varones. Los niños que asistían a las escuelas públicas rurales tuvieron menos riesgo de tener sobrepeso (OR = 0.57, IC del 95%: 0.46, 0.70) y ser obesos (OR = 0.35, IC del 95%: 0.28, 0.44) en comparación con los de las escuelas urbanas públicas o privadas. Tanto el sobrepeso (OR = 2.11, IC del 95%: 1.60, 2.78) como la obesidad (OR = 1.68, IC del 95%: 1.24, 2.28) fueron significativamente más frecuentes entre los niños que asisten a escuelas privadas. Después de ajustar por edad y género, los resultados continuaban siendo todavía estadísticamente significativos. CONCLUSIONES: La prevalencia del sobrepeso/obesidad entre niños de seis a diez años en la RNAS en Jamaica es de 17.7%, correspondiendo las tasas más altas a las hembras, y a los niños o niñas de mayor edad. Los niños y niñas que asisten a escuelas urbanas públicas y privadas presentan una mayor prevalencia que los que asisten a escuelas rurales. Se necesitan intervenciones dirigidas adecuadamente a combatir este problema.

An Experiment in the Introduction to Medicine Course: the Self-image of Physicians Ten Years after Graduation / 医学教育

As part of the curriculum of the Introduction to Medicine course, a questionnaire designed to clarify the images of physicians ten years after graduation was distributed to 120 young physicians affiliated with the Department of Internal Medicine, Nihon University School of Medicine, in order to analyze the prevailing self-image of physicians and their professional identity.<BR>Answers from 14 of the physicians suggested that their self-images and hopes related to private lifewere me same as those typically of non-physicians, that is having a happy family life, enjoying hobbies and cars, and owning real estate. However, their identity as professionals was based on not only specialist qualifications and a M.D. degree, but also “new” criteria such as conducting research, publication of articles, and presentations at academic meetings.<BR>The findings of this survey prompted us to discuss our images of ourselves as physicians and our hopes for the future.