ABSTRACT
Background: The objective of present study was to measure the serum magnesium levels in preterm labor patients, to measure the serum magnesium levels in term labor patients and to correlate the serum magnesium levels in preterm and term labor patients.Methods: It is a prospective case control study conducted in the department of obstetrics and gynecology, KIMS hospital and research Centre, Bengaluru, Karnataka, India. A venous blood sample is drawn from patients admitted to labor room who fulfill the inclusion and exclusion criteria out of which 50 patients belong to the Group-A (preterm labor) and 50 patients belong to Group-B (term labor). Serum magnesium level is measured in both the groups.Results: Women with preterm labor had a significantly reduced serum magnesium level with a mean serum magnesium level of 1.59 mg/dl with a SD of 0.83 whereas the patients with term labor had a mean serum magnesium level of 2.55 mg/dl with a SD of 0.40. The difference of serum magnesium levels observed between the study population and control population is independent of factors like maternal age, parity, gestational age, and socio-economic factors. In this study, it is found that serum magnesium levels are lower in early and late preterm compared to preterm between 33-34+6 weeks.Conclusions: Serum magnesium level can be used as a predicting tool for preterm labor. Preterm labor can be avoided by simple supplementation of Magnesium which might provide an easy and inexpensive means to decrease the problems related to preterm labor. There is a further scope for research on serum magnesium levels based on gestational age.
ABSTRACT
Aims@#Preterm premature rupture of membrane (PPROM) is usually associated with maternal vaginal colonization of Group B Streptococci (GBS). However, there are reports on isolation of Acinetobacter baumannii in PPROM cases. In order to ascertain A. baumannii’s role in PPROM, we determine the colonization of A. baumannii and other common vaginal tract flora, i.e. GBS and Candida albicans, in women with PPROM, and compared them to those with normal labor at term (NLT). The transmissibility of the organisms to their babies was also investigated. @*Methodology and results@#A total of 218 high vaginal swabs from 108 and 100 women with PPROM and NLT respectively were collected. The transmission of these organisms to their 215 babies was determined by swabbing the ears and axillae. These were cultured for isolation of A. baumannii, GBS and C. albicans. Results showed that mothers with PPROM were predominantly colonized with GBS (32.4%), followed by C. albicans (19.4%) and A. baumannii (7.4%), compared to 10.9%, 17.3% and 7.2% respectively, in women with NLT. Between 34 to 50% of the babies of mothers with PPROM acquired the organisms, with GBS being the most significantly (p=0.000) transferred compared to other organisms. Co-existence of A. baumannii with either GBS or C. albicans, or both, did not enhance the occurrence of PPROM. @*Conclusion, significance and impact of study@#Colonization of A. baumannii in vaginal tract of pregnant women does not increase the possibility of PPROM, as compared to GBS.
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Objective To explore the clinical factors influencing the prognosis of patients with gestational trophoblastic neoplasia (GTN) after chemotherapy. Methods The clinical data of 55 patients with gestational trophoblastic diseases in our hospital from 2009 to 2016 were retrospectively analyzed, including 26 cases with hydatidiform mole and 29 cases with GTN (23 cases of invasive mole and 6 cases of choriocarcinoma). Among them, 23 GTN patients with the follow-up human chorionic gonadotropin (HCG)5 U/L for 3 times after chemotherapy were included in this study. The age, reproductive history, lung metastasis, International Federation of Gynecology and Obstetrics (FIGO) stage and other clinical factors which might affect the cure time of GTN patients were analyzed by Cox regression analysis. The relationship between age and reproductive history and cure time were analyzed by Kaplan-Meier survival analysis. Results Cox regression univariate analysis showed that term delivery and abortion were related to the cure time of GTN patients (both P0.05), and the age was close to statistical significance (P=0.051). Cox multivariate analysis showed that term delivery was an independent factor influencing the cure time of GTN patients (P=0.020). Kaplan-Meier survival analysis showed that age (P=0.043), term delivery (P=0.016) and abortion (P=0.026) were related to the cure time of GTN patients after chemotherapy. Conclusion Older women or women who have histories of term delivery or abortion should be alerted to the occurrence of GTN, which has long cure time and the dynamic changes of blood HCG need to be closely monitored.
ABSTRACT
Introducción: el parto pretérmino es el que se produce antes de las 37 sem de gestación; la sepsis vaginal constituye uno de los factores de riesgo predisponentes para este, de ahí que continúe siendo motivo de preocupación para obstetras y neonatólogos. Objetivo: evaluar el uso del Test Mycoplasma System Plus en gestaciones con riesgo de parto pretérmino, así como algunos de sus aspectos clínicos. Métodos: se realizó un estudio retrospectivo descriptivo de enero a septiembre de 2010 en el Hospital Profesor Eusebio Hernández, la muestra estuvo constituida por 88 pacientes ingresadas en el servicio de cuidados especiales perinatales con gestaciones menores de 34 sem a las que se les realizó el test y tuvieron el parto en este centro, los datos fueron recogidos de las historias clínicas e informes de microbiología agrupados en un formulario y procesados mediante estadísticas descriptivas y de distribución de frecuencia. Resultados: el 67 porciento, de las pacientes presentaban infección moderada o severa a ureaplasma mientras que los exudados vaginales simples fueron negativos en un 71,5 porciento, el antimicrobiano más utilizado fue la eritromicina. Conclusiones: la mayoría de las pacientes después del tratamiento adecuado llegaron al término de la gestación, así como presentaban exudados vaginales simple negativos, pero con un alto índice de infección a ureaplasma urealyticum
Introduction: the pre-term labor is produced before the 37 weeks of pregnancy; the vaginal sepsis is one of the predisposing risk factors to it, being a motive of worry for obstetricians and neonatologists. Objective: to assess the use of Test Mycoplasma System Plus in pregnancies with risk of pre-term labor, as well as of its clinical features. Methods: a descriptive and retrospective study was conducted from January to September, 2010 in the Profesor Eusebio Hernández Hospital; sample included 88 patients admitted in the perinatal special care unit with pregnancies under 34 weeks and performing of test who gave birth in this institution; data were collected from the medical records and microbiology reports grouped in a form and processed by descriptive statistics and of frequency distribution. Results: the 6l7 percent of patients had a moderate or severe infection due to ureaplasma where as the vaginal exudates were negatives in the 71.5 percent, the more used antimicrobial agents was the erythromycin. Conclusions: most of patients after an appropriate treatment arrive to a term pregnancy and also had negative simple vaginal exudate but with a high rate of infection due to ureaplasma urelyticum
Subject(s)
Humans , Female , Pregnancy , Vaginal Diseases/diagnosis , Vaginal Diseases/drug therapy , Mycoplasma Infections/complications , Mycoplasma Infections/physiopathology , Obstetric Labor, Premature/microbiology , Obstetric Labor, Premature/prevention & control , Epidemiology, Descriptive , Retrospective StudiesABSTRACT
El embarazo múltiple se asocia a un incremento de la morbimortalidad perinatal. Su incidencia se ha incrementado debido al desarrollo de la reproducción asistida. OBJETIVOS: Identificar el embarazo múltiple y relacionarlo con la edad gestacional al ingreso y al parto; determinar la edad gestacional al parto en relación con el peso de los neonatos; evaluar el momento en que se utilizaron los inductores de la madurez pulmonar fetal y relacionarlo con el síndrome de dificultad respiratoria, así como describir las entidades más frecuentes. MÉTODOS: Se realizó un estudio observacional descriptivo de 566 gestantes, de ellas 40 gemelares ingresadas en el Hogar Materno Ismaelillo entre los años 2006-2009. Se revisaron las historias clínicas y se emplearon los softwares StatGraphic Plus V5 y Excel 2007. RESULTADOS: La gemelaridad constituyó el 7,0 por ciento del total. Entre las que ingresaron antes de las 20 sem la prematuridad fue del 15 por ciento; la incidencia del bajo peso a término fue del 27,5 por ciento; se identificó el síndrome de dificultad respiratoria en el 5,0 por ciento a las 28 sem; la anemia en el 55,0 por ciento y la amenaza de parto pretérmino en el 37,5 por ciento. CONCLUSIONES: El ingreso precoz no guardó relación significativa con el parto pretérmino; predominó el bajo peso a térrmino; el síndrome de dificultad respiratoria fue más frecuente en los grupos en los que se administraron tempranamente los inductores de la madurez pulmonar fetal y la anemia fue la más frecuente
The multiple pregnancy is associated with an increase of perinatal mortality and morbidity. Its incidence has increased due to the development of the assisted reproduction OBJECTIVES: To identify the multiple pregnancy related to gestational age ad admission and to labor, to determine the gestational age at labor in relation to the neonate weight, to assess the moment to use the fetal pulmonary maturity inductors and relate it to breathlessness and to describe the more frequent entities. METHODS: A descriptive and observational study was performed in 566 pregnants (40 twins) admitted in the Ismaelillo Maternal home between 2006 and 2009. Medical records were reviewed and StatGrahic Puls V5 and Excel 2007 were used. RESULtS: The twinning was the 7,0 percent of total. Among those admitted before twinning was of 15,6 percent; incidence of term low weight was of 27,5 percent; breathlessness syndrome was identified in the 6,0 percent at 28 weeks; anemia in the 55,0 percent and preterm labor threat in the 37,5 percent. CONCLUSIONS: The early admission hasn't a significant relation to the preterm labor, there was predominance of term low weight, where the breathlessness syndrome was the more frequent in groups with early applications of inductors of fetal pulmonary maturity and the anemia was also the more frequent