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RESUMO: O presente artigo pretende abordar, por meio do caso O Homem dos Ratos, o caráter ficcional da neurose. Partindo da proposição lacaniana de que a neurose nasce de um furo no saber soberano, o que se busca ressaltar é que, por mais que haja uma intensificação dos excessos e da falta de referências na contemporaneidade, a angústia e o sintoma já estavam presentes desde os tempos de Freud. Assim, com o objetivo de evidenciar que a função paterna é falha por estrutura, investigaremos o complexo de Édipo, fundador do mito de origem, lançando luz sobre o aspecto paradoxal da castração.
Abstract: This paper aims to approach, through the case The Rat Man, the fictional character of the structure of neurosis. Starting from the Lacanian assumption that neurosis is born from a gap on the sovereign knowledge, hereby we aim at highlighting that even though on the present days there is an intensification of excesses and of a lack of reference, the anguish and the symptom were already present in Freud's days. Hence, with the objective of demonstrating that the paternal figure is structurally flawed, we will investigate the Oedipus' Complex, founder of its origin myth, so that we can shed some light on the paradoxical aspect of castration.
Subject(s)
Paternity , Psychoanalysis , Neurotic DisordersABSTRACT
Este artigo traz uma reflexão sobre o caso freudiano O homem dos ratos. Busca elaborar algumas ideias e compreensões através de um referencial basicamente lacaniano, caracterizando alguns aspectos da neurose obsessiva. Visa a aplicar os conceitos revisados ao caso específico.
This article presents a reflection on the freudian case The rat man. It intends to draw some ideas and understandings through a basically Lacanian framework, featuring some aspects of the obsessional neurosis. It aims to apply the reviewed concepts to the specific case.
Este artículo presenta una reflexión sobre el caso freudiano El hombre de las ratas. Busca elaborar algunas ideas y entendimientos a través de un referencial básicamente lacaniano, caracterizando alguns aspectos de la neurosis obsesiva. Tiene como objetivo aplicar los conceptos revisados al caso específico.
Subject(s)
Humans , Male , Young Adult , Psychoanalysis/history , Obsessive-Compulsive DisorderABSTRACT
Objective To explore the method of oleic acid two strike to build a better clinical pathophysiology of acute lung injury animal model state.Methods The 60 male and healthy Sprague-Dawley rats, weighing 180 ～ 220g.According to the time of purchase.No.1, 2, 3 The order No.60, Each number, were randomly divided into 3 groups: normal control group(20 rats) : intravenous injection of normal saline 0.07ml/kg, an hour after intravenous injection of saline 0.03 ml/kg.The traditional group(20 rats) : intravenous injection of oleic acid 0.l ml/kg.The model group(20 rats) : intravenous injection of oleic acid 0.07 ml/kg, one hour after intravenous injection of oleic acid 0.03 ml/kg.Close observation of vital signs of breathing and Hemodynamicsin rats.Stable operation of 30 min, Each operation is stable after 30 minutes of measuring arterial blood gas, lung water content, the change degree evaluation of early lung injury of lung tissue pathology.Through the analysis of arterial blood gas, lung water content, HE stained pathological changes of lung tissue in Smith scoring method to determine the degree of lung injury in rats, to evaluate whether the model was successfully established.Results There are 5 rats died after a sharp drop in blood pressure of oleic acid used in traditional group rats, the changes of hemodynamics of traditional group compared with model group were severe, especially in the 5 ～ 30min after injection of oleic acid.The model group was no death, intravenous injection of oleic acid(0.1 ml/kg) from 7 to 8 min after respiratory frequency rats increased gradually, difficulty in breathing, endotracheal see pink frothy sputum.After 1 h pumping and arterial blood gas results showed that pH (7.17 ± 0.15) PaO2, (41.85 ± 8.16) mmHg was significantly lower than that of normal group(P ＜ 0.01) , oxygenation index (PaO2/FiO2) ≤ 300 mmHg, met the diagnostic criteria of acute lung injury, the moisture content(P ＜ 0.05), according to the Smith score, pathological model group compared with normal group significantly increased(P ＜ 0.01).Conclusion Two hit the body can produce severe inflammatory reaction of lung and lasting, build a close clinical pathophysiology of acute lung injury animal model successfully state.Meet the pathophysiological clinical change of acute lung injury, and can be used for basic and clinical research of acute lung injury in infants.
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BACKGROUND: Newborn neurons have bean shown to induce long-term potentiation (LTP). Activation of N-methyl-D-aspartic acid (NMDA) receptor subunit NR2B plays an important role in mature neurons-induced LTP. But there have been no reports addressing on the effects of NR2B activation on newborn neuron-induced LTP.OBJECTIVE: To investigate the effects of NR2B receptor antagonist Ro25-6981 on LTP induced by newborn neurons in adult rat dentate gyrus.DESIGN, TIME AND SETTING: An electrophysiological recording trial was performed at the Department of Neuroblology,Shanxi Medical University from February to June 2007.MATERIALS: Twenty-six male Wistar rats, aged 3 months, were provided by Laboratory Animal Center, Shanxi Medical University.METHODS: Following sacrifice for brain harvesting under anesthesia, the hippocempus was taken to preparation of 400 μ mol/L brain slices. Using extracellular field potential recordings, low-frequency stimulation was performed in the medial molecular layer of dentate gyrus with insulated bipolar tungsten electrodes. After having stable recordings, LTP was induced under high-frequency tetanic stimulation. LTP was induced with a protocol developed previously (4 trains, 500 ms each, 100 Hz within the train, repeated every 20 s). Only those slices which produced the field excitatory postsynaptic potential of 1 mV or cerebrospinal fluid (ACSF)-induced LTP (ACSF-LTP): brain slices were divided into 2 groups: ACSF group, in which, slices were continuously perfused using ACSF bubbled with 95% O2 and 5% CO2; ACSF+ Ro25-6981 group: a 10-minute treatment with 3μ mol/L Ro25-6981 was performed prior to tetanic stimulation, and the remaining procedures were the same as ACSF divided into 2 groups: BIC group: a 10-minute treatment with 10 μmol/L BIC was performed prior to titanic stimulation; BIC+Ro25-6981 group: 3μ mol/L Ro25-6981 and 10μ mol/L BIC were simultaneously perfused 10 minutes prior to tetanic stimulation.MAIN OUTCOME MEASURES: LTP recording results.minutes of titanic stimulation, LTP was (164.67±2.40)% and (147.56±6.63)% in the BIC and BIC+ Ro25-6981 groups,respectively, and a significant difference existed between the two groups (P ＜ 0.05).
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Background To provide clinical evidence for ablative application by comparison of the analgesic effect following different thalamotomy in rats.Methods Thirty rats were randomly assigned into sham and 4 thalamotomies groups: central medial thalamic nucleus ( CM), parafascicular thalamic nucleus ( PF), ventral posterolateral thalamic nucleus (VPL), and CM +Cigulum (cg). Two μL 10% phenol dissolved in glycerin were used for stereotactic thalamotomy. The thermal pain thresholds before and after procedures were evaluated with the tail stimulate test. The formalin test was carried out in an open field apparatus where the animal formalin-induced responses (licking duration, flexing duration, and flinching frequency of the injected paw) were recorded for 60 min.Results Changes of pain thresholds in all ablative groups were significantly higher than that in the sham group, especially it was higher in VPL group. Differences of the factor thalamotomy were found to be due to the shorter licking in the ablative groups than that in the sham group (P ＜0.01 ), whereas flexing duration and flinching frequency were only slightly affected by thalamotomy. Moreover, licking duration was lower in VPL group than in CM and CM + cg groups ( P ＜0.05), whereas nociceptive responses did not differ between the CM and CM+cg groups (P ＞0.05).Conclusions In acute period, CM, PF, VPL, CM + cg neurolysis all showed to elevate the thermal pain threshold and to reduce the pain-induced behavioral responses related to supraspinal neural circuits (licking of the injected paw). Among them, the damage of VPL might be the most active one. CM + cg damage did not get better antinociceptive effect than single CM ablation.
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Aim To probe into the best conditions for the establishment of endometriosis model in rats by the orthogonal experiment method.Methods Autotransplantation was used to establish the endometriosis model in rats by the orthogonal experiment method in which four main factors were considered to optimize the condition of model,according to the volume of heterotopic endometrium.Results The para ligament of uterus was the best place for transplanting.Both dissecting muscular layer and injecting estrin played an important role in the establishment of endometriosis model in rats. The value of four factors decreased progressively according to the injection of estrin,the dissection of muscular layer,the direction of endometrium implantation and oestrus.Conclusions By optimizing the condition for the establishment of endometriosis model in rats by orthogonal experiment,the volume of heterotopic endometrium was improved.A technology platform for pharmacodynamics research was thus offered.