ABSTRACT
OBJECTIVE:To study the process and mechanism of thermal decomposition of ciprofloxacin hydrochloride(CPLX).METHODS:With Al2O3 as reference substance,the samples in nitrogen gas were analyzed by differential scanning calorimetry(DSC),thermogravimetry(TG),digital thermogravimetry(DTG).The thermal kinetic parameters including the energy of activation(E),pre-exponential factor(A),reaction order(n) and pk value were computed based on the data of the thermal analysis curves.RESULTS:The thermal kinetic parameters were as follows:E=101.18 kJ?mol-1,lnA=26.96 s-,n=1,and pk=7.01,and the storage life of ciprofloxacin hydrochloride under normal temperature was 2 years.CONCLUSION:The thermal analysis method is simple and the result is reliable in the study of thermal decomposition of ciprofloxa-cin hydrochloride.