ABSTRACT
Rupture of a vulnerable plaque and the subsequent thrombus formation are the main cause of acute coronary syndrome (ACS). The key to avoid clinical cardiology event is the early detection and prompt management of vulnerable plaques. Many imaging modalities have been introduced to identify thin-capped fibroatheroma (TFCA), but the morphology and the mechanism of vulnerable plaque rupture are still great concern of clinicians. Intravascular optical coherence tomography (OCT) is an examination based on cardiac catheter. tt uses near-infrared light to obtain up to 10 μm high-resolution mages, to display the in vivo micro-structure of blood vessll wall. With the development of a new generation of frequency-domain OCT (FD-OCT), OCT will play an active role in TCFA. We reviewed here the studies of TCFA involving OCT.