ABSTRACT
Objective To assess the clinical curative effect of acupoint injection for the treatment of nape-back fasciitis by Meta-analysis, thus to provide evidence for the treatment of nape-back fasciitis. Methods A retrieval of literatures concerning treatment of nape-back fasciitis with acupoint injection was carried out in the databases of Cochrane Library, PubMed, CMB, CNKI, Wanfang and VIP. Review Manager 5.3 software was used for the evaluation of methodological quality and bias risk of the included randomized controlled trials(RCT) which met the enrolling requirements. At the same time, Meta-analysis was carried out for the main outcome measure of effective rate and the secondary outcome measures of platelet aggregation rate and thromboxan A2 (TXA2) level. Results A total of 10 RCT involving 833 cases were included. The results showed that the treatment group had higher effective rate than the control group (OR = 7.21, 95％ CI [ 4.16, 12.49] , in the combined effect test Z = 7.04) , and the difference was significant(P < 0.01); the treatment group had better effect on decreasing the platelet aggregation rate {mean difference(MD) being 2.50, 95％ CI [1.34, 3.66], Z =4.23} and on reducing the level of TXA2 (MD = 33.35, 95％CI [22.97, 43.72], Z = 6.30) than the control group, the difference being significant (P < 0.01). Conclusion Acupoint injection exerts certain therapeutic effect for the treatment of nape-back fasciitis, and its effect on reducing blood inflammatory factors is better than that of acupuncture or drug therapy alone. However, due to the small quantity and low quality of the included studies, more large-sample, multi-center and high-quality clinical studies are needed to validate the results.
ABSTRACT
Objective To investigate the protective effects of G CSF on lungs of rats with acute cholangitis and changes in blood TNF and TXA 2/PGI 2 by treating the rats with G CSF. Methods Seventy two Wistar rats were randomized into the control, infected and treated groups. We established the model of cholangitis in the rats with injection of E. coli 25922 into the bile duct. The animals in the treated group were pretreated with G CSF 500 ng/day bid) for 5 days before the E. coli injection. The levels of blood TNF and TXA 2/PGI 2 were measured at the 3rd, 6th and 12th h after the injection. Meanwhile, the morphological changes in lungs of the rats were observed. Results The morphological changes in lungs were milder and levels of blood TNF and TXA 2/PGI 2 were significantly lower in the treated group than in the infected one (P