ABSTRACT
Objective: To investigate the effect of Tongxi Powder (TP) on decreasing the uric acid of mice with acute hyperuricemia. Methods: The mice were divided into model, allopurinol (positive control, 10 mg/kg), low-, mid-, and high-dose (100, 300, and 500 mg/kg) TP groups. Except the model group, mice in other groups were administered once daily for 3 d. The acute hyperuricemia model of mice was established 2 h after the last administration and then ip uric acid (450 mg/kg), and the blood uric acid contents were determined after 80 min. Results: Compared with the model group, TP at mid-and high-dose could obviously decrease the blood uric acid level in mice (P < 0.01), so did allopurinol (P < 0.01). The effect of high-dose TP group was the same as that of allopurinol group. Conclusion: TP could inhibit the increase of blood uric acid in mice with acute hyperuricemia.