Evaluation of clinical effect of 3D printing-aided autologous tooth transplantation for repairing tooth loss / 西安交通大学学报(医学版)

【Objective】 To evaluate the clinical effect of 3D printing technology in autogenous tooth transplantation for tooth loss. 【Methods】 From September 2017 to August 2021, 169 patients (176 teeth) were selected and analyzed regarding age, gender, recipient site, positioning of the donor tooth, transplantation time, and long-term follow-up. 【Results】 A total of 176 autogenous tooth transplants were completed, consisting of 133 cases of traditional autogenous tooth transplantation and 43 cases of autogenous tooth transplantation with 3D printing technology. The donor tooth separation time for autogenous tooth transplantation with 3D printing technology was significantly less than that for traditional autogenous tooth transplantation (P<0.000 1). A total of nine teeth were removed 3 months after the operation due to loosening(autogenous tooth transplantation failure), among which seven failed in traditional tooth transplantation and two failed in autologous tooth transplantation with 3D printing technology. The success rate of traditional tooth transplantation was 77% and the retention rate was 94.7%. The success rate of tooth transplantation with 3D printing technology was 88%, and the retention rate was 95.3%. 【Conclusion】 3D printed tooth donor model can greatly shorten the time of tooth donor, reduce the damage to the periodontal membrane cells of the transplanted teeth, and improve the success rate of tooth transplantation. It is worthy of broad promotion.

Application of digital design combined with 3D-printing technologies in dental autotransplantation / 口腔疾病防治

Objective@#To evaluate the therapeutic effect of dental autotransplantation with the application of digital design combined with 3D printing of donor tooth models and recipient alveolar fossa model preoperatively.@*Methods@# Twelve cases that could not be retained due to tooth fracture or extensive absorption of alveolar bone were recruited in the study. Cone-beam computed tomography (CBCT) data were imported into Mimics software for digital design, and the best-matched third molar was selected as the donor tooth. Replicas of the donor teeth and the recipient socket were printed out with three-dimensional (3D) printing technologies as a simulation model for recipient tooth socket preparation. During tooth autotransplantation, preparation of the recipient tooth socket and the donor tooth were guided by the 3D-printed replicas sequentially. Then, the donor tooth was implanted into the recipient tooth pocket. Patients were followed up at 3, 6 and 12 months after the operation, with CBCT examination to evaluate the status of bone reconstruction and periodontal ligaments at each time point. @*Results@#Twelve patients were transplanted with an autogenous third molar with the apical foramen completely closed. Among them, 7 patients had alveolar fossa infection before the operation, of which 1 had extensive resorption of the alveolar bone due to the infection. All 12 patients recovered well after the operation and were followed up for at least 12 months. In total, 11 caseswere successful in tooth autotransplantation with normal mastication, and 1 case had root resorption 14 months postoperation.@*Conclusion@#Digital design combined with 3D printing technology can assistin the selection of thebest-matched donor tooth and preparation of the recipient socket before tooth transplantation proceduresand reduce the extra-alveolar exposure time of the donor tooth and number of trial placementsintothe alveolar fossa. Thus, this combined strategy can effectively improve the outcome of dental autotransplantation.

Autotrasplante dental: revisión de la literatura y presentación de dos casos / Autogenous tooth transplantation: a review of the literature and report of two cases

El autotrasplante dental se define como el traslado de un diente de su alveolo a un alveolo post-extracción o alveolo confeccionado quirúrgicamente, en la misma persona. Actualmente siguiendo los criterios de selección adecuados así como una técnica quirúrgica minuciosa puede resultar una alternativa terapéutica ideal en ciertos pacientes. Las tasas de éxito han aumentado con el tiempo alcanzando cifras mayores al90%. En el presente artículo se reportan dos casos de éxito de autotransplantesdentales y se revisan las indicaciones, contraindicaciones y criterios de éxito de los mismos.

Autogenous tooth transplantation is defined as the movement of a tooth from its socket to a post-extraction or surgically created socketin the same individual. Today, by following appropriate selection criteria and a refi ned surgical technique, this procedure can prove tobe an ideal therapeutic alternative in certain patients. Success rateshave increased over time, reaching as high as 90%. In this article, wepresent two cases of successful autogenous tooth transplantation and a review of the indications, contraindications, and success criteria associated with these.

Clinical application on restoration of dentition defects using tooth-alveolar bone grafts / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To evaluate the clinical effectiveness of tooth-alveolar bone grafts in repairing dentition defects.</p><p><b>METHODS</b>Forty-five patients with dentition defect were divided into two groups according to different operation methods. In group A (n=24), the tooth-alveolar bone grafts of the transplanted tooth and its surrounding alveolar bone were cut using modified surgical orthodontics and then embedded into the designated planting hole. In group B (n=21), the teeth were extracted through conventional tooth transplantation and then embedded into the prepared planting holes. The transplanted teeth were fixed for about 4-6 weeks using the orthodontic method. During the postoperation, which lasted for 2-12 weeks, root canal treatments were administered selectively. The medical effect was regularly followed up and evaluated.</p><p><b>RESULTS</b>No significant difference was found in the change of color and the periodontal ligament image between the two groups (P>0.05) whereas significant differences were observed in the degree of tooth mobility, the absorption of root and alveolar bone, and the rate of root canal treatment (P<0.05). The curative effect in group A was superior to group B.</p><p><b>CONCLUSIONS</b>Tooth-alveolar bone graft transplantation has overcome some of the limitations of traditional tooth transplantation. Therefore, it is an effective means of repairing dentition defect.</p>

The effect of Emdogain gel on periodontal regeneration in autogenous transplanted dog's teeth.

Aim: The aim of this study was to assess the enamel matrix derivative (EMD) as biomaterial used in autogenous tooth transplantation. Material and Methods: The study consisted of 3 beagle dogs, 5 months old, in which six incisors and six premolars were transplanted to mechanically prepared recipient alveolar sockets. One group of teeth was transplanted to a recipient bed, with EMD in the root surface. The second groups of teeth were transplanted using saline solution in the root surface. Every week, clinical examinations were done. Nine weeks later, the animals were killed and the specimens decalcified and prepared for histological and imunohistochemical analysis. Periodontal healing was evaluated by undertaking histomorphometric investigation and analyzed using the Mann- Whitney test (P = 0.05). Results: In both groups, all the transplanted teeth survived. Between the experimental groups, there was statistically significant difference in the complete healing (P = 0.004). There was statistically significant difference between the treatment group in the occurrence of inflammatory root resorption (P = 0.015) and the occurrence of replacement root resorption (P = 0.041). Conclusions: Emdogain gel used on the surface of transplanted teeth improves the occurrence of complete healing and reduces root resorption.

Autotransplantation of developing third molar in place of grossly destructed first molar – a clinical and radiological study.

Aims And Objectives: To evaluate the success rate of auto transplanted third molars. To consider the possibility of auto transplantation, in selected cases, as a good alternative to prosthodontic rehabilitation including implant insertion, when closing a gap in the dental arch. Materials And Methods: Ten patients of either sex with the age group between 15 to 19 years with developing third molars, having half or two third root development and simultaneously having first molar area in which the tooth is grossly destructed or heavily filled or which is indicated for extraction; with adequate bone support and which is free from acute infection and chronic inflammation are considered. The surgical procedure is performed under local anesthesia with strict aseptic measures. The transplanted tooth is stabilised with an open cap splint with coverage on the occlusal surface of the transplanted tooth. The splint is then secured in place by interdental wiring. Results: Out of 10 cases, clinically, all cases showed marked improvement and radiographically, one case exhibited replacement resorbtion and nine cases showed signs of continued root development but not much of root development was appreciable within one year duration. No abnormality was detected in relation to pulpal, periapical, periodontal conditions. All patients were able to carry out normal function over the transplanted area. Conclusion: Auto transplantation of teeth, when properly indicated and technically carried out with great care, will provide excellent results. It is worth consideration in any case in which there is suitable donor tooth available and so, in selected cases, this method should be preferred over prosthetic rehabilitation.

Minimizing the extra-oral time in autogeneous tooth transplantation: use of computer-aided rapid prototyping (CARP) as a duplicate model tooth

OBJECTIVES: The maintenance of the healthy periodontal ligament cells of the root surface of donor tooth and intimate surface contact between the donor tooth and the recipient bone are the key factors for successful tooth transplantation. In order to achieve these purposes, a duplicated donor tooth model can be utilized to reduce the extra-oral time using the computer-aided rapid prototyping (CARP) technique. MATERIALS AND METHODS: Briefly, a three-dimensional digital imaging and communication in medicine (DICOM) image with the real dimensions of the donor tooth was obtained from a computed tomography (CT), and a life-sized resin tooth model was fabricated. Dimensional errors between real tooth, 3D CT image model and CARP model were calculated. And extra-oral time was recorded during the autotransplantation of the teeth. RESULTS: The average extra-oral time was 7 min 25 sec with the range of immediate to 25 min in cases which extra-oral root canal treatments were not performed while it was 9 min 15 sec when extra-oral root canal treatments were performed. The average radiographic distance between the root surface and the alveolar bone was 1.17 mm and 1.35 mm at mesial cervix and apex; they were 0.98 mm and 1.26 mm at the distal cervix and apex. When the dimensional errors between real tooth, 3D CT image model and CARP model were measured in cadavers, the average of absolute error was 0.291 mm between real teeth and CARP model. CONCLUSIONS: These data indicate that CARP may be of value in minimizing the extra-oral time and the gap between the donor tooth and the recipient alveolar bone in tooth transplantation.

Avaliação da influência de fatores clínicos e radiográficos como preditivos no índice de sucesso de 144 transplantes dentários autógenos / Evaluation of the influence of clinical and radiographic factors as predictive of the success rate in 144 autogenous dental transplants

O presente estudo avaliou uma casuística constituída por 144 transplantes dentários autógenos realizados em 128 pacientes, submetidos a controles periódicos de 6 meses a 23 anos. O objetivo do trabalho foi avaliar a influência de fatores clínicos e radiográficos no índice de sucesso dos transplantes realizados. Clinicamente avaliou-se a alteração na coloração dentária, vitalidade pulpar, comprometimento periodontal, tipo dentário transplantado e sítio receptor. Radiograficamente foram avaliados a presença ou não de reabsorção radicular, anquilose dento-alveolar, alterações no compartimento pulpar, complementação do desenvolvimento radicular, presença de periapicopatia persistente e relação coroa/raiz. Os dados foram coletados, analisados e submetidos a cálculos estatísticos pertinentes. As reabsorções dentárias, a anquilose dentoalveolar, a proporção coroa/raiz, a presença de periapicopatia persistente, o desenvolvimento de bolsa periodontal profunda e a mobilidade dentária destacaram-se de forma significante estatisticamente P<0,05. O tipo dentário doador, o sítio receptor, as alterações na coloração dentária e o desenvolvimento radicular na época da cirurgia do transplante não alcançaram índices de significância relacionados ao insucesso dos casos. A presença de processos esclerosantes pulpares mostrou-se comum aos transplantes bem sucedidos de dentes com rizogênese incompleta. Estes achados contribuem para o desenvolvimento de um protocolo terapêutico bem fundamentado.

The present study examined a sample consisting of 144 autogenous dental transplants performed in 128 patients, subjected to periodic follow-up from 6 months to 23 years. The objective was to evaluate the influence of clinical and radiographic factors in the success rate of the performed transplants. Clinical evaluation aimed the change in tooth color, pulpal vitality, periodontal involvement, transplanted tooth type and recipient site. Radiographic evaluation aimed the presence or absence of root resorption, ankylosis, pulpal changes, complementation of the root development, presence of persistent periapical lesions and crown-root ratio. The data were collected, analyzed and submitted to the relevant statistical calculations. Tooth resorptions, ankylosis, crown to root proportion, presence of persistent periapical lesions, development of periodontal pocket depth and tooth mobility was highlighted as statistically significant P <0.05. The donor tooth type, the receptor site, changes in tooth color and root development at the time of the transplant surgery did not reach levels of significance related to the failure of the cases. The presence of pulpal sclerosis processes shown to be common to successful transplantation of teeth with incomplete root formation. These findings contribute to the development of a reliable therapeutic protocol.

Tooth Transplantation after Surgical Removal of Odontoma: A Case Report

Suppression effects of immature dendritic cells on allogenic teeth rejection in mice / 重庆医科大学学报

Objective: To investigate the suppressive effects of immature dendritic cells derived from donor bone on mice allogenic teeth rejection. Methods: immature dendritic cells derived from mice bone marrow were generated with 50 U/ml granulocyte-macrophage colony-stimulating factor; the phenotype were analyzed by flow cytometry. 2?106 imDC per mouse were administered to the recipients through tail vein 7 days before allogenic teeth transplantation. The suppressive effects of imDC on transplantation rejection were observed through histological section. Results: The infiltration of lymph cell and Inflammatory reaction in allogenic teeth transplantation group were reduced after administration of imDC to the recipients.Conclusion:The allogenic teeth rejection could be lessened by imDC.