Therapeutic effect of Topiramate as monotherapy in patients with partial epilepsy / 临床神经病学杂志

Objective To observe the therapeutic efficacy and safety of Topiramate (TPM) as monotherapy in patients with partial epilepsy.Methods The seizure rate in baseline phase of 30 patients with partial epilepsy (treated by Topiramate as monotherapy for 20 weeks) were observed and recorded before treatment.The TPM starting dosage was 25 mg/d, and then increased 25 mg/d each week for 8 weeks until effective dosage or 200 mg/d for 12 weeks,the change of seizure frequency and bad reaction were found.Results The seizure in 16 cases (53.3%) was totally controlled,seizure reduction ≥75% was in 6 cases (20%),≥50% was in 2 cases (6.7%),