Research on the radioprotective effect of total astragalus flavonoids on the irradiated mice / 重庆医科大学学报

Objective:To explore the radioprotective effect of TFA on the 60Co?-rayirradiated mice and provide an experimental basis for the clinical use of TFA.Methods:Normal female Kunming mice were intragastrically administered with TFA for 3days before exposure to lethal dose of 60Co?-ray radiation and then continuously administered with TFA for 11days.The 30-days survival rate and average life span of irradiated mice were estimated.Meanwhile the body weight,peripheral blood parameters,spleen indexes and the pathological changes of spleen were also observed in the sublethal dose irradiated mice.Results:TFA could not only increase the 30-days survival rate and the average survival days of dead mice(P