ABSTRACT
Objective To research the antitumor effects of the saponin from patrinia villosa on mice cerivical cancer.Methods Total patrinia saponin was purified from patrinia extracts by macroporous adsorption resin.The models of liquid tumor and solid tumor of mice cerivical cancer were setup,and different concentrations of total patrinia saponin (0/250/500 mg/kg) was performed on the mice by intragastric administration and intraperitoneal injection of cyclophosphamide (CTX) were acted on mice.After 15 days,the effect of total patrinia saponin on the inhibition rate of solid tumor and the life span of ascites tumor were conducted with the experiment model in vivo of animal tumor.Results Compared with the control group,the total patrinia saponin (250/500 mg/kg) and CTX (25 mg/kg body weight) significantly reduced the tumor weight of solid tumor and increased the life span of ascites tumor harboring mice (P＜0.05).The inhibition rate of solid tumor was 46.60％ and 52.15％,and the rate of life span increased to 71.42％ and 46.10％ in total patrinia saponin (250/500 mg/kg) group.Conclusion Total patrinia saponin had antitumor action.