ABSTRACT
Se describe el caso clínico de una lactante de 6 meses de edad, residente en el municipio de Palma Soriano, de la provincia de Santiago de Cuba, con antecedente de buena salud, atendida por su médico de familia por presentar lesiones en la piel. En esta ocasión se le diagnosticó impétigo contagioso, para lo cual fue tratada con azitromicina; al séptimo día presentó fiebre de 40 °C y nuevas lesiones en la cara, el tronco, así como en los miembros inferiores y superiores, con ampollas y costras, de manera que fue ingresada en el Hospital Pediátrico de su municipio, con el diagnóstico de síndrome mano-boca-pie. Se le indicó tratamiento sintomático y 24 horas después comenzó a presentar toma del estado general, inflamación de las mucosas bucal, conjuntival, vulvar y anal, además de zonas eritematosas y húmedas, que se extendían por casi toda la superficie corporal. El signo de Nikolski resultó positivo y se corroboró que la paciente presentaba síndrome de Stevens Johnson y necrólisis tóxica epidérmica, pero evolucionó favorablemente
The case report of a 6 months infant girl from Palma Soriano municipality, in Santiago de Cuba who had a history of good health is described. She was assisted by her family doctor due to lesions in the skin. In this occasion she was diagnosed impetigo contagiosa, reason why she was treated with azitromicin; at the seventh day she had fever (40 °C) and new lesions in the face, trunk, as well as in the lower and upper members, with blisters and scabs, so that she was admitted in the Pediatric Hospital of her municipality, with the diagnosis of hand-mouth-foot syndrome. She was indicated symptomatic treatment and 24 hours later her general state began to decline, inflammation of the oral, conjuntival, vulvar and anal mucous, besides erithematous and humid areas that extended for almost the whole body surface. Nikolski sign was positive and it was corroborated that the patient presented the Stevens Johnson syndrome and epidermic toxic necrolysis, but she had a favorable clinical course
Subject(s)
Humans , Female , Infant , Stevens-Johnson Syndrome , Necrolytic Migratory Erythema , Skin DiseasesABSTRACT
Este trabalho salienta a possibilidade de a alteração do excipiente de medicamentos tomados por longos períodos desencadear a Necrólise Epidérmica Tóxica. É feita a descrição clínica de paciente de 30 anos com farmacodermia associada ao uso de antirretrovirais.
This work emphasizes the possibility that changing the excipient of some drugs taken over long periods can trigger Toxic Epidermic Necrolysis. This article shows the clinical aspects of a patient who took AZT/r since March/2007. Thus, the suspicion that this drug would trigger Stevens-Johnson syndrome isnt significative. On the other hand, the fact that the antiretroviral vehicle has been changed leads to a strong suspicion that it could be involved in triggering this syndrome. It is reported the clinical description of a 30-year patient eruption associated with the use of retroviral.