ABSTRACT
A severe cutaneous reaction in a female dog after administration of penicillin and cephalexin is described, in which the main signs presented by the patient were fever, lack of appetite, and detachment of epidermis in the dorsal region of body.The established treatment was surgical debridement of the region, topical application of Aloe Vera with sugar, and systemic antibiotic therapy with ciprofloxacin, resulting in the recovery and wound closure in approximately 45 days.
Subject(s)
Animals , Female , Dogs , Cephalexin/administration & dosage , Stevens-Johnson Syndrome , beta-Lactams/adverse effects , beta-Lactams/administration & dosage , beta-Lactams/therapeutic useABSTRACT
La eritrodermia es una enfermedad inflamatoria cutánea generalizada. Generalmente se presenta en la edad media de la vida y en la mayoría de los casos es debida a exacerbación de dermatosis preexistentes. Puede asociarse a manifestaciones sistémicas como poliadenopatías, hepatomegalia, eritrosedimentación acelerada, leucocitosis y/o eosinofilia, entre otros. Con el fin de conocer la incidencia y la etiología de esta patología en nuestro hospital realizamos un estudio retrospectivo y observacional sobre 3160 historias clínicas de pacientes internados en el servicio de clínica médica. Detectamos 25 casos de eritrodermia lo cual implica una incidencia del 0.79%. La edad media de presentación fue 48 años. La etiología más frecuente fue la secundaria a medicamentos, siendo los β lactámicos los más involucrados. La alteración sistémica mayormente observada fue la eosinofilia (62%). El comienzo de la enfermedad en la mayoría de los casos fue agudo.
Erythroderma is an inflammatory and generalized skin disorder (more than 90% of the body surface area) accompanied by a variably degree of scaling. Often affects middle ages of life and it is usually caused by the exacerbation of a preexisting dermatoses. It could be associated to systemic manifestations like lymphadenopathy, liver enlargement, leukocytosis and elevated erythrocyte sedimentation. The aim of this study was to determinate the incidence and also the etiology of this pathology in our environment. We made a retrospective and observable study based on the research of 3160 clinic stories of patients that were in the hospital at the Clinical Department. We found that 25 patients were diagnosed with erithroderma (incidence 0.79%). The mean age at diagnosis was 48 years. The most common causative factor was drug reactions been the β lactams the most involved drug. Eosinophilia was the most important systemic manifestation (62%). The onset of erithroderma was usually abrupt and florid.