ABSTRACT
Neuropathic pain(NPP)has always been a problem that puzzles the medical community because of its unclear pathogenesis and poor drug treatment. With the development of molecular biology and electrophysiological techniques, studies have shown that the complex pathological mechanism of NPP may be related to the activation of transient receptor potential vanillic acid sub-type 1(TRPV1). TRPV1 receptors are mainly expressed in peripheral sensory neurons, which can detect harmful stimuli in the external and internal environment and transmit information to the central nervous system, thereby playing an important role in peripheral neuropathic pain. TRPV1 modulators exert analgesic effects by blocking the pain transmission function of TRPV1 and have become a potential therapeutic agent in the treatment of NPP. This article reviews TRPV1 receptor-mediated NPP models and the role of TRPV1 modulators in NPP treatment.