Clinicopathologic Analysis of Four Cases of Primary Ovarian and Parovarian Transitional Cell Carcinoma / 대한부인종양콜포스코피학회잡지

Four cases of primary transitional cell carcinoma (TCC) arising in the ovary (3 cases) and the parovarium (1 case) were collected for clinicopathologic analysis. The mean age was 46.2 years (range, 39-57 years). Two patients complained abdominal discomfort and vaginal discharge, respectively. Other 2 cases were incidentally found from routine check. Grossly, the tumors were solid and cystic (2 cases), solid (1 case) and surface papillary growth on capsule (1 case). Microscopically, the tumor showed almostly same to the histologic features of TCC of urinary bladder. Three cases were pure TCC, and one was mixed TCC and serous carcinoma. FIGO stage were 1 IIa, 2 IIc, and 1 IIIc. Treatment was surgery with adjuvant chemotherapy. Two patients are alive with no evidence of disease, and two have lung or brain metastasis.

Prognostic Value of Expression of c-erbB-2 in Urinary Bladder Cancer / 대한비뇨기과학회지

C-erbB-2, one of epidermal growth factor receptor gene family, may have an important role in progression of transitional cell carcinoma (TCC of the urinary bladder. We herein immunohistochemically examined 52 bladder TCC specimens for expression of c-erbB-2 gene product to investigate its prognostic value. Interrelationship between expression of c-erbB-2 and stage, grade, expression of proliferating cell nuclear antigen (PCNA), and clinical outcomes were analyzed. Overexpression of c-erbB-2 was significantly higher in invasive tumors as compared with superficial tumors and in high grade tumors as compared with low grade tumors (p<0.005). However, there were no significant correlations between the degree of expression of c-erbB-2 and progression-free survival in patients with superficial bladder TCC as well as actual-survival in patients with invasive bladder TCC. There also was no significant correlation between the expression of c-erbB-2 and PCNA. These results suggest that c-trbB-2 may be an important marker of malignant potentials and invasiveness of bladder TCC, but immunohistochemical study for its expression in bladder TCC may not provide additional prognostic information to stage and grade of the tumors.

The Study on the Relevance between Human Papillomavirus (HPV) Infections and Transitional Cell Carcinoma of the Urinary Bladder in Korean / 대한비뇨기과학회지

The role of human papillomavirus (HPV) infection in the development of transitional cell carcinoma (TCC) of the bladder is highly controversial because the detection rates of the HPV in TCC of the bladder were highly variable in the previous published literatures. Two recent publications highlight this controversy, but they examined the paraffin-embedded specimens of TCC of the bladder. This study was designed to evaluate the conflicting results of the role of HPV in the development of bladder carcinoma using non-fixed fresh frozen specimens. 1tenty patients were underwent the transurethral resection of the bladder tumor from April 1995 to July 1995 and were diagnosed as pure TCC of the urinary bladder on pathologic examination. The prevalence of type 16 and 18 HPV was investigated with the polymerase chain reaction (PCR) on non-fixed fresh frozen specimens, from 20 cases of TCC of the bladder. Six samples of normal bladder obtained at cystoscopic examination were served as negative controls. Positive controls were CasKi cell line for HPV 16 and the HeLa cell line for HPV 18. HPV type 16 deoxyribonucleic acid (DNA) was detected in none of the 20 cases of transitional cell carcinoma of the bladder and in none of the normal urinary bladder cases. HPV type 18 DNA was detected in none of the 20 cases of TCC and in none of the normal urinary bladder cases. There was complete agreement between results of gel electrophoresis analysis and Southern blot hybridization. These results strongly suggest that HPV might play little role in the development of TCC of the urinary bladder in the general population of Korea.