Short-term clinical evaluation of different pharmaceutical forms of triamcinolone acetonide in the treatment of oral lichen planus of erosive type / 实用口腔医学杂志

Objective:To observe the efficacy of different forms of triamcinolone acetonide( TA) in the treatment of buccal erosive oral lichen planus (EOLP). Methods:120 EOLP patients were randomly divided into 4 groups(n=30) and treated with Kangfuxin mouth-wash followed by topical ointment of( TA) , TA injection, TA mouth-wash and only Kangfuxin mouth-wash only, respectively. Before treatment, 1, 2 and 4 weeks after treatment, the pain (VAS score) and erosion area were measured, the effects were compared among groups. Results:The VAS scores of A, B and C groups were significantly lower than those of the control group after 1, 2 and 4 week treatment, and the total effective rate was significantly higher than that of the control group, respectively(P0. 05). The average erosion area of group A and B was significantly smaller than that of the control group after 1, 2 and 4 week treatment(P0. 05), but 4 weeks after treatment, the average area of erosion of group C was significantly smaller than that of the control group(P<0. 05). Conclusion:Triamcinolone acetonide is effective in the treatment of OLP and the oral oint-ment form is safe and convenient for OLP treatment.

Intravitreal Triamcinolone Acetonide as Adjunctive Treatment in Vitrectomy for Proliferative Diabetic Retinopathy

PURPOSE: This study evaluated the safety and efficacy of crystalline triamcinolone acetonide (TA) in pars plana vitrectomy for proliferative diabetic retinopathy. METHODS: A total of 152 eyes of 143 patients were enrolled in the study, and divided into 3 groups: Group I underwent pars plana vitrectomy without intravitreal injection of TA, group II underwent TA-assisted vitrectomy, and group III underwent TA-assisted vitrectomy and received an intravitreal injection of 4 mg TA at the end of surgery. RESULTS: In Groups I, II and III, 31 eyes (62.0%), 35 eyes (67.3%), and 41 eyes (82.0%), respectively, showed frequency of gain in visual acuity, group III showed greater improvements in vision after surgery than group I; the difference was statistically significant. Four eyes (8.0%) in group I, 12 eyes (23.1%) in group II, and 12 eyes (24.0%) in group III had an intraocular pressure higher than 21 mmHg after the operation; there were statistically significant differences in groups II and III compared to group I (P=0.04, P=0.03, respectively). Ten eyes (20.0%) in group I, 3 eyes (5.8%) in group II, and 3 eyes (6.0%) in group III needed additional surgery. Groups II and III, which received TA-assisted vitrectomy, had lower incidences of re-operation than group I (P=0.03, P=0.04, respectively). CONCLUSIONS: Triamcinolone acetonide-assisted vitrectomy appears to be a potentially useful way to reduce the incidence of re-operation and an intravitreal injection of TA at the end of surgery may be useful for improving postoperative visual acuity.

Comparison of Indocyanine Green and Triamcinolone Acetonide for Internal Limiting Membrane Peeling in Macular Hole

PURPOSE: To compare the surgical outcomes and complications of triamcinolone acetonide (TA) with those of indocyanine green (ICG) staining of the internal limiting membrane (ILM) during idiopathic macular hole surgery. METHODS: Twenty-four eyes of 23 consecutive patients with an idiopathic macular hole underwent vitrectomy, ILM peeling, and intravitreal gas injection. For enhanced visualization of ILM, ICG was used in 13 eyes and TA in the remaining 11 eyes. Functional and anatomical success rates and surgical complications were compared between the groups. RESULTS: The mean follow-up periods were 10.8 months (ICG group) and 7.5 months (TA group). Best corrected visual acuity increased by two or more lines in 10 eyes (76.9%) of the ICG group and in eight eyes (72.7%) of the TA group (P=1.000). Anatomical closure after the first surgery was achieved in 10 eyes (76.9%) of the ICG group and in all 11 eyes of the TA group (100%) (P=0.223). Postoperative atrophic changes in the retinal pigment epithelium (RPE) in the macular hole bed was found in two eyes of the ICG group and in three eyes of the TA group. All of these (5 eyes) showed the photoreceptor outer segment defect in the closed macular areas by optical coherence tomography and had a postoperative best corrected visual acuity of 0.3 or less. CONCLUSIONS: In view of the potential toxicities of ICG, TA appears to be a promising alternative adjuvant for ILM peeling during macular hole surgery. However, postoperative RPE atrophy was detected as a postoperative complication in both the ICG and TA groups. Further study is needed to evaluate the TA toxicity in macular hole surgery.

Efficacy of Intravitreal Triamcinolone Acetonide Injections at the End of Pars Plana Vitrectomy in Proliferative Diabetic Retinopathy

PURPOSE: To evaluate the efficacy of intravitreal injections of triamcinolone acetonide (TA) at the end of pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR). METHODS: We analyzed 50 patients (52 eyes) who underwent PPV for treatment of PDR and received an intravitreal injection of 4 mg TA at the end of surgery. The study group (Group 1) was compared with a control group (Group 2, 46 patients, 51 eyes) (matched with the study group for preoperative parameters) who underwent PPV without intravitreal injection of TA. RESULTS: In Group 1, the grade of anterior chamber cells at postoperative days 1 and 7 was significantly lower than that of Group 2. There was slight mean IOP elevation in Group 1 at postoperative weeks 2, 3, 4, and 8, but it was not statistically significant. Forty-four eyes (84.6%) from Group 1 showed better visual acuity at the last follow-up than at the preoperative visit (Group 1). Thirty-two eyes (62.8%) from Group 2 showed better visual acuity at the last follow-up than at the preoperative visit. The degree of visual improvement was 0.75 logMAR in Group 1 and 0.59 logMAR in Group 2. Vitreous hemorrhage occurred in 9 eyes (17.3%) from Group 1 and in 19 eyes (37.3%) from Group 2. However, the differences in the occurrence of neovascularization in iris and neovascular glaucoma between two groups were not statistically significant. CONCLUSIONS: Intravitreal TA injection at the end of PPV seems to be effective in improving visual acuity and decreasing early postoperative inflammation and the frequency of vitreous hemorrhage.

A Case of Papular Elastorrhexis Improved by Intralesional Injections of Triamcinolone Acetonide / 대한피부과학회지

Papular elastorrhexis is a rare disorder characterized by multiple, white, non-follicular, firm papules usually occurring on the trunk during adolescence. Histologically, there are focal areas of collagen homogenization with decreased and fragmented elastic fibers. There has been no established treatment for this disease. We report a case of papular elastorrhexis in a 19-year-old female patient improved by intralesional injections of triamcinolone acetonide (TA).