ABSTRACT
The administration of flaxseed oil or flaxseed oil plus trientine in diabetic rats reduced triglyceride, very low density lipoprotein, and total cholesterol. Furthermore, the combined treatment significantly increased superoxide dismutase activity and attenuated serum Cu2+. The results suggest that the administration of flaxseed oil plus trientine is useful in controlling serum lipid abnormalities, oxidative stress, restoring heart structure, and reducing serum Cu2+ in diabetic rats.
Subject(s)
Animals , Antioxidants/pharmacology , Chelating Agents/administration & dosage , Chelating Agents/pharmacology , Cholesterol/blood , Copper/blood , Diabetes Mellitus, Experimental/blood , Diabetes Mellitus, Experimental/drug therapy , Diabetes Mellitus, Experimental/pathology , Drug Therapy, Combination , Heart/anatomy & histology , Heart/physiopathology , Hyperlipidemias/blood , Hyperlipidemias/drug therapy , Hyperlipidemias/pathology , Linseed Oil/administration & dosage , Linseed Oil/pharmacology , Lipids/blood , Male , Oxidative Stress/drug effects , Rats , Rats, Wistar , Trientine/administration & dosage , Trientine/pharmacology , Triglycerides/bloodABSTRACT
Wilson's disease is a treatable autosomal recessive inherited disorder of copper metabolism due to mutation of the copper transporting gene. The basic strategy of treatment is to reduce the amount of copper in the liver and other tissues by administering both a low copper diet and copper-chelating agents. D-penicillamine is the first choice as a copper-chelating agent. Some serious side effects could occur in 3~5% of all patients following D-penicillamine therapy. We report a 19 year-old male with Wilson's disease who developed nephrotic syndrome 6 months after the initiation of D-penicillamine therapy. Prednisolone was administered to control nephrotic syndrome and D-penicillamine was switched to trientine. Urinary remission was achieved within a week and maintained thereafter. Nephrotic syndrome was proven to be MCNS by kidney biopsy.