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1.
Article in English | IMSEAR | ID: sea-151322

ABSTRACT

In the present investigation, our aim of synthesis is to find a molecule having multi drug treatment means the drug which resists the inflammation produce due to microbial infection. So, 2,4,5-triphenyl-1H-imidazole-1-yl derivatives were synthesized and tested for their antiinflammatory activity in-vitro using Phenylbutazone as a reference drug and antimicrobial activity using clotrimazole and ciprofloxacin as a standard drug. Compound 6b was found to be the most potent derivative of the series.

2.
Article in English | IMSEAR | ID: sea-161549

ABSTRACT

2,4,5-triphenylimidazoles/1-(2-Methyl)-3-(2-hydroxyphenyl)imidazo[1,5- a]pyridine could be obtained in excellent yields by the one-pot three-component condensation of benzil/2-acetyl pyridine, aldehyde and ammonium acetate in the presence of catalytic amount of the inexpensive, readily available NaH2PO4 under solvent-free condition. The mixture was ground together in a mortar with a pestle at room temperature for short reaction time and easy operation under solvent free condition.

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