Effect of Montelukast combined with Beclomethasone in the treatment of pediatric asthma and the influence on the levels of serum IgE,IL-4 and TNF-α / 中国基层医药

Objective To analyze the effect of Montelukast combined with Beclomethasone in the treatment of asthma and the influence on the levels of serum immunoglobulin E(IgE),interleukin 4(IL-4) and tumor necrosis factor alpha ( TNF-α) .Methods 88 children with pediatric asthma were divided into the two groups according to random number table method,44 cases were in each group.The control group was only treated with Beclomethasone, once a day,while the observation group was treated with Montelukast combined with Beclomethasone,10mg,once a day,last for 3 months.The levels of serum IgE,IL-4 and TNF-αof the two groups before and after treatment was observed.The clinical effective rate and adverse reactions were evaluated.Results After the treatment,the levels of serum IgE,IL-4 and TNF-αof the two groups were significantly lower than those before treatment ( t=2.21,2.44, 2.21,9.61,9.02,9.61,all P0.05).Conclusion There was good curative effect and security of Montelukast and Beclomethasone in the treatment ofasthma,which significantly reduced the levels of serum IgE,IL-4 and TNF-αand inhibited the action of the airway chronic inflammation.

The changes of plasma levels of cytokines in patients of hypoxic-ischemic encephalopathy and its clinical significance / 中国医师进修杂志

Objective To explore the role of cytokines on the pathogenesis of hypoxic-ischemic en-cephalopathy (HIE). Method The levels of peripheral blood interleukin (IL)-6, IL-8, tumor necrosis factor-alpha (TNF-α) in 40 HIE and 40 healthy neonates were detected at the 1st, 3rd and 7th day after birth by using radioimmunoassay. Results Compared with healthy neonates, at the 1 st, 3rd after birth, the level of peripheral blood IL-6 was decreased [(52.3±24.5)ng/L vs (80.1±28.6)ng/L and (56.9±28.5) ng/L vs (78.6±28.9)ng/L, respoctively], but IL-15 and TNF-α were increased [IL-8:(0.68±0.23)ng/L vs (0.47±0.13)ng/L and (0.63±0.22)ng/L vs (0.40±0.16)ng/L, TNF-α: (1.17±0.30)ng/L vs (0.91± 0.30) ng/L and (1.14±0.29)ng/L vs (0.96±0.34)ng/L]in HIE infants. Conclusion The changes of plas-ma levels of IL-6, IL-8 and TNF-α in neonatal HIE possibly play an important role in the pathophysiologic mechanisms of HIE.