ABSTRACT
Objective To investigate the pathological characteristics and clinical significance of ultrasructure in lung tissues of type 2 diabetic adult patients.Methods Normal lung tissues far from lung neoplasm in 10 cases of type 2 diabetic patients associated with lung cancer were observed under a transmission electron microscope. Results Type Ⅱ alveolar cells became small,and cell superficial microvilli disappeared,Osmiophilic lamellar body became atrophy,lacked lamellar structure and formed a solid globule with high electrom dense;Rough endoplasmic reticulum and mitochodria in cytoplasm were enlarged cystiformly,and there were translucent materials deposited in vesicle,euchromatin decreased,heterochromatin condensed;The basement membrane of bronchial capillary were diffusely thickened and mostly showed onion-skin like change,protein deposited around and mixed with basement membrane.Conclusion Lung is confirmed to be the target organ of chronic damage in diabetes.Pathological changes of pulmonary tissues induced by diabetes have its specific characteristics,which are different from other pulmonary diseases.These changes are pathological basis of pulmonary function abnormalities.