ABSTRACT
OBJECTIVE: To reduce adverse drug reactions and resistance of cefamandole nafate for injection and ceftriaxone sodium for injection by gold zone method. METHODS: The relationships between doses and effects were studied. Using gold zone as the middle range and dividing empirical range into three sections are the keypoints to the study design. RESULTS: The incidences of drug adverse reactions of both drugs complied with U-shaped rule, i.e, with the increase of doses (mg·kg-1·d-1), the adverse reaction rates first decreased and then rose, and the bottom of the U-shaped curve was in the gold zone. Central limit theorem and normal distribution demonstrated that the appropriate doses existed in the gold zone, which was less than 1/4 of the empirical range but covered nearly 70% of the probability. The relationship between the resistance and dose also followed U-shaped rule, and the bottom of the U-shaped curve was also in the gold zone. CONCLUSION: Abuse, adverse reactions and resistance are the three major problems in antibiotics use today. Using gold zone method to determine dose may be a special breakthrough in solving these problems. Copyright 2012 by the Chinese Pharmaceutical Association.