ABSTRACT
OBJECTIVE:To observe the clinical efficacy of recombinant human brain natriuretic peptide (rhBNP) combined with levosimendan in acute decompensated heart failure(ADHF). METHODS:In retrospective study,120 cases diagnosed as AD-HF were divided into observation group and control group according to treatment plan,with 60 cases in each group. The patients of control group received rhBNP on the basis of conventional treatment,intravenously pulsed with dose of 0.15 μg/kg firstly,then maintained dose of 0.007 5 μg/kg viacontinuous intravenous pumping for 24-72 h;On the basis of control group,treatment group received levosimendan with loading-dose of 12 μg/(kg·min)for 10 min,maintenance dose of 0.1 μg/(kg·min)via intravenous pump,for 24 h,adjusted according to clinical manifestations of patients. The vital signs,hemodynamic and UCG indexes,the rate of dyspnea recovery,plasma level of BNP,urine and the occurrence of ADR were recorded in 2 groups. RESULTS:The vital sign and hemodynamic indexes of control group had no significant change 1 h after treatment;the levels of HR,RR,SBP,MPAP and MPCWP in 2 groups after treatment were significantly lower than before,while the levels of SaO2 and CO were significantly higher than before,with statistical significance (P0.05). 48 h after treatment,LVEF of 2 groups were increased while plasma levels of BNP were decreased,compared to before treatment;the improvement of observation group was more significant than control group,with statistical significance(P0.05). CONCLU-SIONS:rhBNP combined with levosimendan could effectively improve vital sign,hemodynamic indexes,UCG indexes and dys-pnea,and decrease the plasma level of BNP with good safety.
ABSTRACT
Objective Studying the related factors of left ventricular hypertrophy for hypertensive disease, to provide the basis for clinical treatment. HZ Methods 500 hypertensive disease patients were performed dynamic monitoring of blood pressure and UCG. Then 130 patients with left ventricular hypertrophy were compared the dynamic blood pressure, age, sex and diseases course with 130 patients who had not left ventricular hypertrophy. Results (1) Systolic pressure, the load and the night descent rate of systolic pressure were significantly related to left ventricular hypertrophy, there was obviously difference in two groups. To the patients with systolic pressure and diastolic pressure were all increased, the incidence rate of left ventricular hypertrophy was reduced. (2) The age of left ventricular hypertrophy group was higher than no left ventricular hypertrophy group. (3) The female's incidence rate of hypertensive disease in left ventricular hypertrophy group was higher than no left ventricular hypertrophy group. (4) The course of diseases in left ventricular hypertrophy group was extended than no left ventricular hypertrophy group. The incidence rate of left ventricular hypertrophy was obviously higher in the patients whose blood pressure was increased in the daytime. Conclusion (1) The pulse pressure is a important forecast factor in numerous risk factor. (2) The advanced age is a risk factor to hypertensive disease. (3) The female hypertensive disease patients take place left ventricular hypertrophy is easier than the male. (4) Left ventricular hypertrophy is significantly related to hypertensive disease course, and isn't significantly related to blood pressure's durative. The clinic must think highly of observing and evaluating the pulse pressure, the long disease course of old female patients. There is important clinical significance to reinforce monitoring the risk factor of left ventricular hypertrophy, and to perform pertinent treatment and prevention for the high risk patients.