ABSTRACT
OBJECTIVE: To prepare compound ornidazole gel and conduct its quality control. METHODS: The gel was prepared with 0.6% carbopol - 940 as base and with ornidazole and cimetidine as main ingredients. Contents of 2 constituents were determined directely by UV - spectrophotometry. The stability of the finished product was investigated as well. RE-SULTS:The gel obtained was good in appearance, shaping and spreading. The linear ranges for ornidazole and cimetidine were all 0.5-32uuuuuuuuuug/ ml. The average recovery rates of ornidazole and cimetidine were 100.58% (RSD= 1.17%) and 100.59% (RSD=1.61%), respectively. The stability investigation results were in line with the requirement of Chinese Pharmacopeia 2000 version. CONCLUSION:The formula of compound gel is reasonable; its preparation technics is simple and the quality is reliable; and which meets the requirements of clinical medication.
ABSTRACT
OBJECTIVE:To compare the in vitro dissolubility of four kinds of commercial chlorphenamine maleate tablets. METHODS: To determine the dissolubility of four kinds of domestic commercial chlorphenamine meleate tablets by paddle method and to analyse the dissolution parameters, T50, Td, m, by variance analysis method. RESULTS: The dissolution parame- ters of the different tablets were T50(30. 3 197, 17. 3 695, 20. 1038, l4. 3 651), Td(34. 6 088, 26. 7 162, 28. 0 514, 22. 1 593)and m (2. 7 676, 0. 8 505, 1. 0 992, 0. 8 448). CONCLUSION: The statistical results indicated that there were significant differences between them(P