ABSTRACT
Protein ubiquitination is one of the important mechanisms regulating protein stability and activity under physiological condition. Among them, E1/E2/E3 ligases and deubiquitination enzyme play an important regulatory role in the process of protein ubiquitination, while deubiquitination may induce the occurrence of tumors, asthma and other diseases. Ubiquitin-specific peptidases, as the main members of the deubiquitination enzyme family, have been proved to be closely related to the occurrence and development of tumors, among which some ubiquitin-specific peptidases have been used as new targets for anti-tumor therapy. Therefore, this study aims to briefly review the regulatory mechanisms of ubiquitin-specific peptidases in the process of tumor genesis and development, which will provide more research directions for tumor therapy.